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Icosapent Ethyl

Icosapent is an omega-3 fatty acid, a type of "good" fat found in certain foods that helps reduce the levels of "bad" fat in your body. It's used to lower high levels of triglycerides (a type of fat) in individuals with pancreatitis or cardiovascular disease.

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Frequently Asked Questions

Can I take Icosapent with food?
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Absolutely! It's recommended that you take Icosapent along with your meals to significantly enhance its absorption.

Do I need to alter my diet while taking Icosapent?
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Yes, a low-fat diet would help Icosapent work effectively in reducing your triglyceride levels.

I missed a dose of Icosapent, what should I do?
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Just take it as soon as you remember. But, if it's almost time for your next dose, skip the missed one. Never take a double dose.

Can I just stop taking Icosapent after my triglycerides are back to normal?
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No. Always consult your doctor before changing or stopping the medication.

Comprehensive Drug Guide

How Does Icosapent Ethyl Work?

Icosapent is a medication that helps lower high levels of fats, called triglycerides, in the blood. It is made from a type of omega-3 fatty acid found in fish oil. Icosapent reduces triglyceride production in the liver and helps the body break them down more efficiently. By lowering triglycerides, Icosapent can help reduce the risk of heart problems, such as heart attacks and strokes, especially in people who already have heart disease or are at high risk.

What is Icosapent Ethyl Used For?

Lowering high triglycerides: Icosapent is primarily used to reduce high levels of triglycerides (fat) in the blood, which can lead to heart problems if left untreated.

Reducing the risk of cardiovascular events: Icosapent is prescribed to help lower the risk of heart attack, stroke, and other heart-related problems in people who have heart disease or are at high risk of developing heart issues, even if they are already taking cholesterol-lowering medications like statins.


It is often used alongside a healthy diet and lifestyle changes to manage cholesterol and triglyceride levels.

Common Dosages

Here are the commonly manufactured dosages of Icosapent:

  • 1 gram (1,000 mg) capsules - this is the standard form of Icosapent.


Typical Dosing

FDA Approved Indications

Treatment of Severe Hypertriglyceridemia (High Triglycerides):

  • Indication: Icosapent is FDA-approved for the treatment of severe hypertriglyceridemia, where triglyceride levels are 500 mg/dL or higher.
  • Dosing:
  • Standard Dose: 2 grams (2,000 mg) twice daily, 4 grams daily. It is taken with food to improve absorption and effectiveness.
  • Goal: The primary goal is to lower triglyceride levels and reduce the risk of complications like pancreatitis.

Reduction of Cardiovascular Risk:

  • Indication: Icosapent is FDA-approved to reduce the risk of heart attack, stroke, and other cardiovascular events in adults with high triglycerides who also have either established heart disease or are at high risk for heart disease (e.g., diabetes), even when on statin therapy.
  • Dosing:
  • Standard Dose: 2 grams (2,000 mg) twice daily, 4 grams daily. This dose is used alongside other medications like statins to help reduce cardiovascular risk.

Off-Label Uses

Non-Alcoholic Fatty Liver Disease (NAFLD):

  • Off-label Use: Icosapent has been studied for potential benefits in reducing liver fat in patients with non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NASH).
  • Dosing: Typically, 2 grams (2,000 mg) twice daily is used, similar to its dosing for triglyceride management. The goal is to reduce liver fat and improve liver function.

Adjunct Therapy for Lipid Control in Patients Not at Goal with Statins Alone:

  • Off-label Use: Icosapent may help control elevated triglycerides in patients whose levels are still high despite taking statins or other lipid-lowering medications.
  • Dosing: To further lower triglycerides and improve overall lipid profile, the recommended dose is 2 grams (2,000 mg) twice daily.

Prevention of Atherosclerosis Progression:

  • Off-label Use: Icosapent has been explored for slowing the progression of atherosclerosis, a condition in which plaque builds up in the arteries, potentially reducing the risk of future cardiovascular events.
  • Dosing: Similar to the FDA-approved dosing, 2 grams (2,000 mg) twice daily is commonly used.

Who Shouldn't Take Icosapent Ethyl?

  • Have a known hypersensitivity to Icosapent or any of its constituents.
  • Have ongoing liver disease or disorder.
  • Are breastfeeding (it's not known whether Icosapent harms the baby).
  • Have ongoing serious heart rhythm problems.

Advice From The Pharmacist

  • Take Icosapent along with your meals to boost its absorption.
  • Do not alter the dosage without consulting with your doctor.
  • If you experience any side effects, notify your doctor immediately.
  • Store it at room temperature, keeping it away from heat and moisture.
  • Have your blood tested regularly, to monitor your body?s response to Icosapent.

Side Effects of Icosapent Ethyl

Common Side Effects

Joint pain (arthralgia): One of the most frequently reported side effects.

Sore throat: Some individuals may experience mild throat discomfort.

Diarrhea: Gastrointestinal upset, including diarrhea, can occur.

Nausea: Mild nausea or upset stomach is a possible side effect.

Abdominal discomfort: Some people report stomach pain or discomfort.

Gout: In some cases, Icosapent can increase uric acid levels, potentially triggering gout in susceptible individuals.

Mild rash: Skin rashes may develop, although this is less common.

Uncommon/Severe Side Effects

Irregular heartbeat (atrial fibrillation or atrial flutter): Some people may experience an irregular or fast heartbeat, which can increase the risk of stroke or other heart problems.

Bleeding: Icosapent can increase the risk of bleeding, especially in people who are on blood-thinning medications (like warfarin) or have bleeding disorders. Watch for signs like unusual bruising, nosebleeds, or blood in the stool or urine.

Severe abdominal pain: This could indicate a more serious gastrointestinal issue and should be evaluated by a healthcare provider.

Signs of stroke: Sudden weakness or numbness, especially on one side of the body, difficulty speaking, or vision changes could be signs of a stroke.

Risks and Warnings of Icosapent Ethyl

  • There can be a risk of irregular heartbeat with the usage of Icosapent.
  • Icosapent should not be used in individuals with allergies to fish or shellfish. It's an Omega-3 fatty acid derived from fish oil.

Interactions with Icosapent Ethyl

Common Drug Interactions

  • Warfarin
  • Beta-blockers
  • ACE inhibitors
  • Statins

Alternatives to Icosapent Ethyl

Omega-3-Acid Ethyl Esters (Lovaza)

  • How it works: Like Icosapent, Lovaza is derived from fish oil and is used to lower triglycerides. It contains a combination of omega-3 fatty acids, including EPA and DHA, which help reduce triglyceride levels.

Fenofibrate (Tricor, Lofibra)

  • How it works: Fenofibrate is a fibrate drug that helps reduce triglycerides and increase HDL ("good") cholesterol by promoting the breakdown of fats in the blood.

Gemfibrozil (Lopid)

  • How it works: Another fibrate, gemfibrozil, helps lower triglyceride levels and can raise HDL cholesterol. It is less commonly used but may be an option for certain patients.

Niacin (Niaspan)

  • How it works: Niacin, also known as vitamin B3, helps lower triglycerides and increase HDL cholesterol by reducing the liver's production of LDL ("bad") cholesterol and triglycerides.

Statins (e.g., Atorvastatin, Rosuvastatin)

  • How it works: Statins primarily reduce LDL cholesterol but can also modestly lower triglycerides. They reduce the liver's production of cholesterol and help lower cardiovascular risk.

Ezetimibe (Zetia)

  • How it works: Ezetimibe lowers cholesterol by reducing cholesterol absorption from the small intestine. While its primary effect is on cholesterol, it can also help reduce triglycerides.