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Omega-3-acid Ethyl Esters
Omega-3-acid ethyl esters are a prescription medication used primarily to reduce triglyceride levels in adults with severe hypertriglyceridemia. Derived from fish oil, these omega-3 fatty acids are effective in lowering triglycerides and may also provide cardiovascular benefits.
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Frequently Asked Questions
How quickly do omega-3-acid ethyl esters work?
Patients may begin to see a reduction in triglyceride levels within 4 to 12 weeks of starting treatment.
Can I take omega-3-acid ethyl esters with food?
Yes, it is recommended to take them with food for better absorption.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using omega-3-acid ethyl esters?
There are no specific dietary restrictions while using omega-3-acid ethyl esters, but maintaining a heart-healthy diet is encouraged.
Is omega-3-acid ethyl esters safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using omega-3-acid ethyl esters during these periods.
Comprehensive Drug Guide
How Does Omega-3-acid Ethyl Esters Work?
Omega-3-acid ethyl esters work by decreasing the production of triglycerides in the liver and increasing their clearance from the bloodstream. They may also have anti-inflammatory properties and improve overall lipid profiles.
Common Dosages
- Capsules: Common strengths include 1 g and 1.2 g.
Typical Dosing
- The usual dose for managing triglyceride levels is 4 g (four 1 g capsules) taken orally once daily, or as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Severe Hypertriglyceridemia: as an adjunct to diet for the reduction of triglyceride levels in adults with elevated triglyceride levels.
Who Shouldn't Take Omega-3-acid Ethyl Esters?
- Known hypersensitivity to omega-3-acid ethyl esters or any component of the formulation.
- Active liver disease or severe hepatic impairment.
Advice From The Pharmacist
- Take omega-3-acid ethyl esters with food to enhance absorption.
- Monitor triglyceride levels regularly to assess the effectiveness of treatment.
- Report any signs of allergic reactions, such as rash or difficulty breathing, to your healthcare provider.
Side Effects of Omega-3-acid Ethyl Esters
Common Side Effects
- Fishy aftertaste
- Nausea
- Diarrhea
- Indigestion
- Flatulence
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Increased risk of bleeding, especially in individuals taking anticoagulants.
Risks and Warnings of Omega-3-acid Ethyl Esters
- Bleeding Risk: Use caution in patients taking blood thinners, as omega-3 fatty acids can increase bleeding risk.
- Allergic Reactions: Individuals with fish allergies should avoid omega-3-acid ethyl esters derived from fish sources.
Interactions with Omega-3-acid Ethyl Esters
Common Drug Interactions
- Anticoagulants and Antiplatelet Agents: Monitor for increased bleeding risk when used concurrently.
- Other Lipid-Lowering Agents: Use with caution and monitor lipid levels to avoid potential interactions.
Alternatives to Omega-3-acid Ethyl Esters
- Other Omega-3 Supplements: Such as krill oil or other fish oil formulations for managing triglycerides.
- Statins: For patients needing additional lipid-lowering therapy.
