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Diovan HCT
Diovan HCT is a combination medication containing valsartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. It is used to treat high blood pressure (hypertension) by helping to relax blood vessels and reduce the amount of fluid in the body, thereby lowering blood pressure. This medication is typically prescribed when blood pressure cannot be adequately controlled with a single drug.
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Frequently Asked Questions
How long does it take for Diovan HCT to lower blood pressure?
It may take 2 to 4 weeks to see the full blood pressure-lowering effects of Diovan HCT, though some improvement may be noticed within the first few days.
Can Diovan HCT be used long-term?
Yes, Diovan HCT is commonly used as a long-term treatment for hypertension. Regular check-ups with your healthcare provider are important to monitor its effectiveness and any potential side effects.
What should I do if I miss a dose of Diovan HCT?
Take the missed dose as soon as you remember, unless it’s close to your next scheduled dose. Do not double up on doses to make up for the missed one.
Can I take Diovan HCT with other blood pressure medications?
Yes, Diovan HCT can be combined with other blood pressure medications, but your healthcare provider will determine the best combination based on your specific condition.
Is Diovan HCT safe during pregnancy?
No, Diovan HCT should not be used during pregnancy due to the risk of harm to the developing baby. Consult your healthcare provider immediately if you become pregnant while taking this medication.
Comprehensive Drug Guide
How Does Diovan HCT Work?
- Valsartan: Blocks the effects of angiotensin II, a substance that causes blood vessels to constrict. This results in the dilation of blood vessels, lowering blood pressure.
- Hydrochlorothiazide: Increases urine production, helping the body eliminate excess sodium and fluid, which also reduces blood pressure.
What is Diovan HCT Used For?
Management of hypertension in patients whose blood pressure is not controlled adequately with monotherapy.
Common Dosages
Diovan HCT is available in the following tablet strengths:
- 80 mg/12.5 mg, 160 mg/12.5 mg, 160 mg/25 mg, 320 mg/12.5 mg, 320 mg/25 mg (valsartan/hydrochlorothiazide)
Typical Dosing
FDA Approved Indications
- The usual starting dose is 160 mg/12.5 mg once daily. Dosage may be adjusted based on blood pressure response, with a maximum dose of 320 mg/25 mg once daily.
Who Shouldn't Take Diovan HCT?
Diovan HCT should not be used in individuals with:
- Severe renal impairment
- Anuria (inability to urinate)
- Hypersensitivity to valsartan, hydrochlorothiazide, or other sulfonamide-derived drugs
- Severe liver disease
- Pregnancy
Advice From The Pharmacist
- Take Diovan HCT at the same time each day, with or without food.
- Drink plenty of water to stay hydrated, especially since the diuretic can increase urination and may lead to dehydration.
- Be mindful of potassium levels, as valsartan can raise potassium while hydrochlorothiazide can lower it. Your healthcare provider may check your potassium levels regularly.
- Avoid excessive sun exposure, as hydrochlorothiazide may make your skin more sensitive to sunlight.
Side Effects of Diovan HCT
Common Side Effects
- Dizziness
- Lightheadedness
- Fatigue
- Increased urination
- Muscle cramps
Uncommon/Severe Side Effects
- Electrolyte imbalances (e.g., low potassium or sodium)
- Severe hypotension (low blood pressure)
- Kidney dysfunction
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Diovan HCT
Pregnancy Warning: Diovan HCT can harm a developing fetus, particularly in the second and third trimesters. It should not be used during pregnancy.
Electrolyte Imbalance: Hydrochlorothiazide can cause electrolyte imbalances, including low potassium and sodium levels. Monitoring is essential, especially in individuals at risk.
Kidney Function: This medication may affect kidney function, especially in individuals with pre-existing kidney disease. Regular monitoring of kidney function is recommended.
Interactions with Diovan HCT
Common Drug Interactions
- Potassium supplements or potassium-sparing diuretics: May increase potassium levels and the risk of hyperkalemia.
- NSAIDs: Nonsteroidal anti-inflammatory drugs like ibuprofen may reduce the effectiveness of Diovan HCT and increase the risk of kidney problems.
- Lithium: Diovan HCT may increase lithium levels, leading to toxicity.
- Alcohol: May increase the blood pressure-lowering effect of Diovan HCT and cause excessive dizziness or fainting.
Alternatives to Diovan HCT
- Losartan-Hydrochlorothiazide (Hyzaar): Another combination of an ARB and a thiazide diuretic used to treat hypertension.
- Amlodipine-Valsartan (Exforge): A combination of a calcium channel blocker and an ARB used to manage high blood pressure.
- Lisinopril-Hydrochlorothiazide (Zestoretic): An ACE inhibitor combined with a diuretic for the treatment of high blood pressure.
- Olmesartan-Hydrochlorothiazide (Benicar HCT): Another ARB-diuretic combination used for hypertension.
