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Exforge
Exforge (generic name: amlodipine/valsartan) is a combination medication used to treat high blood pressure (hypertension). Amlodipine is a calcium channel blocker, and valsartan is an angiotensin II receptor blocker (ARB). Together, they help relax blood vessels and reduce blood pressure, lowering the risk of heart attacks and strokes.
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Frequently Asked Questions
How long does it take for Exforge to lower blood pressure?
Blood pressure may start to decrease within 1 to 2 weeks, but full effects may take 4 to 6 weeks.
Can I take Exforge if I’m pregnant?
No, Exforge should not be used during pregnancy, as it can harm the developing fetus.
Does Exforge cause weight gain?
Exforge is not typically associated with weight gain, but if you notice unusual swelling or weight changes, contact your healthcare provider.
Can I stop taking Exforge if my blood pressure improves?
Do not stop taking Exforge without consulting your healthcare provider, as stopping it suddenly may cause your blood pressure to rise again.
Can I drink alcohol while taking Exforge?
It is best to limit alcohol consumption, as it can further lower your blood pressure and increase the risk of dizziness.
Comprehensive Drug Guide
How Does Exforge Work?
Amlodipine works by relaxing the smooth muscles of blood vessels, allowing them to widen and reduce blood pressure. Valsartan blocks the effects of angiotensin II, a hormone that narrows blood vessels, further lowering blood pressure and reducing the workload on the heart.
Common Dosages
- 5 mg amlodipine / 160 mg valsartan
- 10 mg amlodipine / 160 mg valsartan
- 5 mg amlodipine / 320 mg valsartan
- 10 mg amlodipine / 320 mg valsartan
Typical Dosing
- The typical starting dose is 5 mg/160 mg once daily, which may be increased as needed based on blood pressure response.
Typical Dosing
FDA Approved Indications
- Hypertension (high blood pressure) in patients who may benefit from combination therapy.
Who Shouldn't Take Exforge?
- Severe kidney or liver disease
- Pregnancy (due to risk of harm to the fetus)
Advice From The Pharmacist
- Take Exforge once daily with or without food, and try to take it at the same time each day.
- If you miss a dose, take it as soon as you remember, but do not take two doses at once.
- Exforge may cause dizziness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you.
Side Effects of Exforge
Common Side Effects
- Dizziness
- Swelling of the hands or feet
- Flushing
- Fatigue
Uncommon/Severe Side Effects
- Low blood pressure (hypotension)
- Kidney problems
- Allergic reactions
Risks and Warnings of Exforge
- Pregnancy Warning: Exforge can cause injury or death to the developing fetus. Do not use Exforge if you are pregnant or planning to become pregnant.
- Kidney Impairment: Valsartan can worsen kidney function in some patients, especially those with pre-existing kidney disease.
Interactions with Exforge
Common Drug Interactions
- ACE inhibitors: Combining Exforge with other drugs that affect the renin-angiotensin system, such as ACE inhibitors, can increase the risk of kidney problems or hyperkalemia (high potassium).
- NSAIDs: Nonsteroidal anti-inflammatory drugs (e.g., ibuprofen) can reduce the effectiveness of Exforge and increase the risk of kidney problems.
Alternatives to Exforge
- Lotrel: A combination of amlodipine and benazepril used to treat hypertension.
- Diovan HCT: A combination of valsartan and hydrochlorothiazide, a diuretic, for hypertension.
- Norvasc (amlodipine): A calcium channel blocker used to treat high blood pressure and chest pain.
