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Lisinopril-hydroCHLOROthiazide
Lisinopril-Hydrochlorothiazide is a combination medication that combines lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, with hydrochlorothiazide, a thiazide diuretic. This medication is primarily prescribed for the treatment of hypertension (high blood pressure). By combining these two agents, it helps to lower blood pressure more effectively than either medication alone, reducing the risk of heart disease, stroke, and kidney problems.
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Frequently Asked Questions
How long does it take for Lisinopril-Hydrochlorothiazide to lower blood pressure?
Patients may start to see improvements in their blood pressure within a week, but it can take up to several weeks for full effects.
Can I take this medication with other blood pressure medications?
Always consult your healthcare provider before combining with other antihypertensives to avoid potential interactions and excessive lowering of blood pressure.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.
Are there any dietary restrictions while taking this medication?
While there are no strict dietary restrictions, it's advisable to monitor potassium intake and maintain a balanced diet.
What should I do if I experience side effects?
If you experience side effects that are bothersome or severe, contact your healthcare provider for guidance on how to manage them or whether adjustments to your treatment plan are needed.
Comprehensive Drug Guide
How Does Lisinopril-hydroCHLOROthiazide Work?
Lisinopril works by inhibiting the enzyme ACE, which prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in vasodilation (widening of blood vessels) and reduced blood pressure. Hydrochlorothiazide helps to lower blood pressure by promoting the excretion of sodium and water through urine, thereby decreasing blood volume and further lowering blood pressure.
What is Lisinopril-hydroCHLOROthiazide Used For?
Common Dosages
- Combination tablets: typically containing 10 mg, 20 mg, or 30 mg of lisinopril and 12.5 mg of hydrochlorothiazide.
Typical Dosing
- The usual starting dose is 10 mg/12.5 mg once daily, which may be adjusted based on the patient's response and blood pressure.
- Maintenance doses may vary, with a maximum recommended dose of 40 mg/25 mg per day.
Typical Dosing
FDA Approved Indications
- Hypertension: to lower blood pressure in adults
- Heart failure: as part of a broader treatment strategy
Who Shouldn't Take Lisinopril-hydroCHLOROthiazide?
- Known hypersensitivity to lisinopril, hydrochlorothiazide, or any other component of the formulation
- History of angioedema related to previous ACE inhibitor therapy
- Severe renal impairment or anuria
Advice From The Pharmacist
- Take Lisinopril-Hydrochlorothiazide exactly as prescribed, preferably at the same time each day.
- Monitor your blood pressure regularly to ensure the medication is effective.
- Be aware of signs of dehydration, such as dizziness or fainting, especially when standing up quickly.
- Inform your healthcare provider of any other medications you are taking, as interactions may occur.
Side Effects of Lisinopril-hydroCHLOROthiazide
Common Side Effects
- Dizziness or lightheadedness
- Cough (more common with lisinopril)
- Fatigue
- Increased urination
Uncommon/Severe Side Effects
- Allergic reactions (rash, swelling, difficulty breathing)
- Elevated potassium levels (hyperkalemia)
- Kidney dysfunction
Risks and Warnings of Lisinopril-hydroCHLOROthiazide
- Hypotension: Especially in patients who are salt-depleted or volume-depleted, hypotension can occur. Monitor blood pressure closely.
- Electrolyte Imbalance: Regular blood tests may be necessary to monitor potassium and renal function during treatment.
- Pregnancy: This medication should not be used during pregnancy as it can harm the developing fetus.
Interactions with Lisinopril-hydroCHLOROthiazide
Common Drug Interactions
- Diuretics: Combining with other diuretics may increase the risk of hypotension and electrolyte imbalances.
- NSAIDs: Nonsteroidal anti-inflammatory drugs can reduce the antihypertensive effect of lisinopril.
- Potassium Supplements: Caution is advised when taking potassium supplements or potassium-sparing diuretics, as this may lead to hyperkalemia.
Alternatives to Lisinopril-hydroCHLOROthiazide
- Amlodipine: A calcium channel blocker used to treat high blood pressure.
- Valsartan: An angiotensin receptor blocker (ARB) used for hypertension and heart failure.
- Metoprolol: A beta-blocker that can help manage hypertension.
