Browse Medications by Drug Class: Substance P/Neurokinin-1 Receptor Antagonists

Written by Amar Lunagaria
Pharm.D • NiHowdy Founder

Reviewed by James Wong
Pharm.D • NiHowdy Founder
Published Jan 15, 2025

What are Substance P/Neurokinin-1 Receptor Antagonists?
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List of drugs in Substance P/Neurokinin-1 Receptor Antagonists
Drug Name | More Information | NiHowdy Prices & Bitcoin Rebate |
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Aprepitant | Aprepitant Information | Aprepitant Pricing |
Emend | Emend Information | Emend Pricing |
Emend Tri-Pack | Emend Tri-Pack Information | Emend Tri-Pack Pricing |
Varubi (180 MG Dose) | Varubi (180 MG Dose) Information | Varubi (180 MG Dose) Pricing |
Brief history about Substance P/Neurokinin-1 Receptor Antagonists?
How do Substance P/Neurokinin-1 Receptor Antagonists work?
What are Substance P/Neurokinin-1 Receptor Antagonists used to treat?
Nausea and Vomiting
NK-1 receptor antagonists are integral to preventing CINV, especially delayed-phase nausea and vomiting, which occur 24-72 hours after chemotherapy. Medications like aprepitant and fosaprepitant are used in combination with other antiemetics to provide complete protection against both acute and delayed symptoms. NK-1 receptor antagonists such as rolapitant are effective in managing PONV, reducing the risk of nausea and vomiting after surgery. They are particularly useful for patients at high risk of these complications, improving recovery and reducing hospital stays. In patients undergoing radiation therapy, NK-1 receptor antagonists help prevent RINV by targeting the neurokinin-1 receptor pathways involved in emesis. This improves patient comfort and adherence to treatment protocols.
Who should consider Substance P/Neurokinin-1 Receptor Antagonists medications?
Adults
Adults undergoing chemotherapy, radiation therapy, or surgery often benefit from NK-1 receptor antagonists to prevent nausea and vomiting. These medications are particularly valuable for individuals with a history of severe nausea or those receiving highly emetogenic therapies.
Children
NK-1 receptor antagonists are used cautiously in pediatric populations, primarily for managing CINV or PONV. Doses are adjusted based on age and weight, and close monitoring ensures safety and efficacy in younger patients.
Seniors
Seniors undergoing medical treatments that induce nausea benefit significantly from NK-1 receptor antagonists. These medications provide targeted relief without causing excessive sedation or cognitive impairment, making them suitable for older adults with complex medical needs.
Are Substance P/Neurokinin-1 Receptor Antagonists safe?
Can I take Substance P/Neurokinin-1 Receptor Antagonists during pregnancy?
Are Substance P/Neurokinin-1 Receptor Antagonists safe to take while lactating?
Are Substance P/Neurokinin-1 Receptor Antagonists controlled substances?
Side effects of Substance P/Neurokinin-1 Receptor Antagonists?
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