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ZTlido
ZTlido (lidocaine topical system 1.8%) is a transdermal patch used for the treatment of pain associated with post-herpetic neuralgia (PHN), a nerve pain condition that occurs following shingles. ZTlido contains lidocaine, a local anesthetic that numbs the skin and underlying tissues, reducing pain and discomfort in the affected area. The patch provides a continuous release of lidocaine to relieve pain for up to 12 hours.
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Frequently Asked Questions
How long does ZTlido take to start working?
ZTlido typically begins to relieve pain within 30 minutes to 1 hour after application. The effect lasts for up to 12 hours while the patch is worn.
Can I wear more than one ZTlido patch at a time?
No, you should apply only one ZTlido patch at a time unless directed by your healthcare provider. Using more than one patch can increase the risk of lidocaine toxicity.
What should I do if the patch falls off before 12 hours?
If the patch falls off before 12 hours, you can attempt to reapply it to the same area or replace it with a new patch. Be sure not to exceed the 12-hour wear time in a 24-hour period.
Can I use ZTlido patches every day?
Yes, ZTlido patches are designed for daily use. However, the patch should be removed after 12 hours, and there should be a 12-hour break before the next patch is applied.
Is ZTlido safe to use on sensitive skin?
ZTlido can cause mild irritation in some individuals. If you have sensitive skin, monitor the area for any signs of excessive irritation, and consult your healthcare provider if discomfort persists. Avoid applying the patch to broken or inflamed skin.
Comprehensive Drug Guide
How Does ZTlido Work?
ZTlido works by releasing lidocaine onto the skin, which blocks sodium channels in nerve cells, preventing the transmission of pain signals to the brain. This local anesthetic effect helps to numb the area of application and provides relief from the burning, stabbing, or aching pain commonly associated with post-herpetic neuralgia.
Common Dosages
- 1.8% lidocaine transdermal patch
Typical Dosing
- For pain associated with post-herpetic neuralgia (PHN): Apply one patch to the painful area once daily for up to 12 hours. The patch should be applied to intact skin and removed after 12 hours, followed by a 12-hour patch-free period.
Typical Dosing
FDA Approved Indications
- Pain associated with post-herpetic neuralgia (PHN)
Who Shouldn't Take ZTlido?
- Known hypersensitivity to lidocaine or other amide-type local anesthetics
- Severe liver disease (without consulting a healthcare provider, as lidocaine is metabolized by the liver)
Advice From The Pharmacist
- Apply ZTlido to clean, dry, and intact skin in the area of pain. Avoid applying to areas of skin that are irritated, broken, or infected.
- ZTlido patches are flexible and designed to stick well, even during moderate activity, but ensure they remain fully adhered to the skin throughout the 12-hour period.
- After removing the patch, fold it in half with the sticky sides together and dispose of it properly to prevent accidental exposure to children or pets.
- If the patch falls off before 12 hours, it can be reapplied, but do not exceed the maximum time limit of 12 hours in a 24-hour period.
- Avoid contact with water while wearing the patch (e.g., swimming, bathing), as this may reduce its adhesive properties.
Side Effects of ZTlido
Common Side Effects
- Mild skin irritation or redness at the application site
- Itching or burning sensation on the skin
- Nausea or dizziness (rare)
Uncommon/Severe Side Effects
- Allergic reactions (swelling, rash, difficulty breathing)
- Severe skin irritation (blistering or peeling at the application site)
Risks and Warnings of ZTlido
- Local Skin Reactions: Mild redness, irritation, or rash may occur at the site of application. If skin reactions worsen or do not resolve after patch removal, discontinue use and consult a healthcare provider.
- Systemic Absorption: Although rare, lidocaine from the patch can be absorbed into the bloodstream, especially if multiple patches are used at once or worn for longer than 12 hours. Signs of lidocaine toxicity include confusion, dizziness, and irregular heartbeat.
- Heat Exposure: Avoid exposing the patch to heat sources (e.g., heating pads, hot baths), as this can increase the amount of lidocaine absorbed and raise the risk of systemic side effects.
Interactions with ZTlido
Common Drug Interactions
- Other local anesthetics: Using other topical or injectable anesthetics while using ZTlido may increase the risk of systemic lidocaine absorption.
- Class I antiarrhythmics (e.g., mexiletine, procainamide): These medications can interact with lidocaine, leading to an increased risk of toxicity.
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): These can increase the levels of lidocaine in the blood, raising the risk of side effects.
Alternatives to ZTlido
- Lidoderm (lidocaine patch 5%): Another topical anesthetic patch for the treatment of post-herpetic neuralgia.
- Capsaicin cream: A topical treatment derived from chili peppers that helps relieve nerve pain.
- Gabapentin: An oral medication used to treat nerve pain, including post-herpetic neuralgia.
- Pregabalin (Lyrica): An oral medication used for nerve pain relief, often prescribed for conditions like PHN.
