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Pregabalin
Pregabalin is an antiepileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Pregabalin also affects chemicals in the brain that send pain signals across the nervous system. Some common side effects include dizziness, drowsiness, and swelling, but your doctor will usually ensure the benefits outweigh these issues.
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Frequently Asked Questions
Can I drink alcohol while taking pregabalin?
It's recommended to avoid alcohol as it can enhance the sedative effects of pregabalin, causing dizziness or drowsiness.
Can I just stop taking pregabalin abruptly?
No, it's advised against abruptly stopping pregabalin. Discontinuing suddenly can cause withdrawal symptoms. Your doctor will guide you on how to taper off slowly.
Can I take pregabalin if I have kidney disease?
It's best to consult with your doctor. They may need to adjust your dosage because the drug is primarily cleared through the kidneys.
Does pregabalin cause weight gain?
It's possible. Some people do experience weight gain while taking pregabalin, especially if using it longterm.
I missed a dose of pregabalin, what should I do?
No worries! Take it as soon as you remember if it's not too close to the next dose. If it's almost time for your next dose, skip the missed one. Never double up on doses!
Will pregabalin make me feel drowsy?
Yes, pregabalin can cause dizziness and drowsiness. If you feel any such symptoms, it's better not to drive or do anything that requires alertness.
Comprehensive Drug Guide
How Does Pregabalin Work?
Pregabalin is an analog of the neurotransmitter GABA. It works by binding to the alpha2delta site in the CNS, reducing the release of several neurotransmitters including glutamate, norepinephrine, substance P, and calcitonin generelated peptide.
What is Pregabalin Used For?
FDA indications: Pregabalin is used for managing conditions like neuropathic pain, fibromyalgia, and seizures.
Offlabel uses: It has also been used to treat generalized anxiety disorders.
Common Dosages
Capsules: 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg
Oral solution: 20mg/mL
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Neuropathic pain: 75 to 150mg, twice per day.
- Fibromyalgia: 75 to 150mg, twice per day.
- Seizures: 75 to 150mg, twice per day.
Off-Label Uses
- For offlabel uses:
- Generalized anxiety disorders: 75 to 600mg, divided into two to three doses per day.
Who Shouldn't Take Pregabalin?
- Have kidney disease or be on dialysis.
- Have congestive heart failure.
- Are pregnant, planning to become pregnant, or are breastfeeding (it's not known whether pregabalin harms the baby).
- Have a history of depression or suicidal thoughts.
- Have a history of drug or alcohol addiction.
- Have any kind of allergy to pregabalin.
Advice From The Pharmacist
- Do not stop using pregabalin suddenly, even if you feel fine. Stopping suddenly may cause withdrawal symptoms.
- Pregabalin can cause dizziness and drowsiness. Do not drive or operate machinery until you know how this medication affects you.
- Pregabalin may cause weight gain and swelling of the hands, legs, and feet. Report any sudden weight gain or swelling to your doctor.
- Avoid drinking alcohol while taking pregabalin as it can increase some of pregabalin's side effects.
- Monitor for changes in mood or symptoms of depression. Inform your doctor if you have any new or worsening symptoms of depression or suicidal thoughts.
Side Effects of Pregabalin
Common Side Effects
- Dizziness and drowsiness are the most common side effects.
- Possible weight gain and swelling of the hands, legs, and feet.
- Dry mouth, blurred vision, and constipation may also occur.
Uncommon/Severe Side Effects
- Rare side effects:
- Severe muscle pain or tenderness, especially if you also have a fever.
- Severe skin reaction, difficulty breathing, sickness, or stomach pain.
- Severe side effects:
- If any signs of an allergic reaction like rash, itching, or swelling of the face/tongue/throat, severe dizziness, or trouble breathing occur.
Risks and Warnings of Pregabalin
- Other than the risk of allergic reactions, users should exercise caution if they have a history of heart conditions, kidney disease, depression, or any substance dependence history.
- Overuse could lead to reduced efficacy and more serious side effects like heartrelated complications.
Interactions with Pregabalin
Common Drug Interactions
- Rosuvastatin
- Oxycodone
- Lorazepam
- Alcohol
Alternatives to Pregabalin
- Gabapentin
- Duloxetine
- Amitriptyline
- Nortriptyline
- Lidocaine patch
- Capsaicin cream
