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Zionodil
Zionodil (tadalafil) is a phosphodiesterase type 5 (PDE5) inhibitor prescribed for the treatment of erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and in some cases, pulmonary arterial hypertension (PAH). It works by relaxing the blood vessels, allowing increased blood flow to certain areas of the body, particularly the penis, which helps men achieve and maintain an erection. It also helps improve symptoms of BPH by relaxing the muscles in the bladder and prostate.
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Frequently Asked Questions
How long does Zionodil last?
Zionodil can be effective for up to 36 hours after taking a single dose, allowing for greater flexibility in the timing of sexual activity.
Can I take Zionodil with food?
Yes, Zionodil can be taken with or without food, though it may take longer to work if taken with a heavy or high-fat meal.
Is it safe to drink alcohol while taking Zionodil?
While small amounts of alcohol are unlikely to cause problems, drinking large amounts can increase the risk of side effects such as dizziness and low blood pressure.
What should I do if I miss a dose for BPH?
If you miss a dose of Zionodil for BPH, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take your next dose as normal. Do not double up doses.
Can women use Zionodil?
Zionodil is not approved for use in women. It is specifically designed for men with erectile dysfunction or benign prostatic hyperplasia. If women need a medication for pulmonary arterial hypertension, they may use Adcirca, which contains the same active ingredient.
Comprehensive Drug Guide
How Does Zionodil Work?
Zionodil works by inhibiting the enzyme PDE5, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP). By blocking this enzyme, cGMP levels increase, leading to the relaxation of smooth muscles and dilation of blood vessels. This process improves blood flow to the penis, aiding in erections, and reduces symptoms of BPH by relaxing the prostate and bladder.
Common Dosages
- 2.5 mg, 5 mg, 10 mg, and 20 mg tablets
Typical Dosing
- For erectile dysfunction (ED): The typical dose is 10 mg taken before sexual activity, with the option to increase to 20 mg or decrease to 5 mg based on efficacy and tolerance.
- For benign prostatic hyperplasia (BPH): The recommended dose is 5 mg once daily, taken at the same time each day.
- For pulmonary arterial hypertension (PAH): Under the brand name Adcirca, the dose is typically 40 mg once daily.
Typical Dosing
FDA Approved Indications
- Erectile dysfunction (ED)
- Benign prostatic hyperplasia (BPH)
- Pulmonary arterial hypertension (PAH) (under a different brand name, Adcirca)
Who Shouldn't Take Zionodil?
- A history of heart problems, particularly those who have been advised against sexual activity
- Severe liver or kidney impairment
- Use of nitrates for chest pain or riociguat (another medication for PAH), as this can lead to a dangerous drop in blood pressure
Advice From The Pharmacist
- Zionodil can be taken with or without food, but avoid consuming large amounts of alcohol as it can increase the risk of side effects such as dizziness and low blood pressure.
- Do not take Zionodil more than once a day. For ED, it should be taken at least 30 minutes before sexual activity, but the effects can last up to 36 hours.
- Do not take Zionodil if you are also using nitrates or certain other blood pressure medications, as this can cause a serious drop in blood pressure.
- If you experience an erection lasting more than 4 hours (priapism), seek immediate medical attention.
Side Effects of Zionodil
Common Side Effects
- Headache
- Flushing (warmth or redness in the face or chest)
- Indigestion
- Muscle aches or back pain
Uncommon/Severe Side Effects
- Sudden vision or hearing loss
- Chest pain or irregular heartbeat
- Prolonged erection (priapism) lasting more than 4 hours
Risks and Warnings of Zionodil
- Heart Health: Since Zionodil can affect blood flow and blood pressure, patients with heart conditions or those taking blood pressure medications should use this drug with caution.
- Vision and Hearing Loss: Rarely, Zionodil can cause sudden vision or hearing loss. If this occurs, discontinue use and seek medical attention immediately.
- Priapism: Prolonged erections lasting more than 4 hours can cause permanent damage to the penis if not treated promptly.
Interactions with Zionodil
Common Drug Interactions
- Nitrates: Zionodil should never be used with nitrates (such as nitroglycerin) due to the risk of a dangerous drop in blood pressure.
- Alpha-blockers: These medications for high blood pressure or prostate problems can also interact with Zionodil, causing dizziness or fainting.
- Alcohol: Excessive alcohol can increase the risk of side effects such as dizziness and low blood pressure when taken with Zionodil.
Alternatives to Zionodil
- Viagra (sildenafil): Another PDE5 inhibitor commonly used to treat erectile dysfunction.
- Levitra (vardenafil): Another alternative used for erectile dysfunction that has a shorter duration of action than Zionodil.
- Cialis (tadalafil): A brand name for tadalafil, the same active ingredient in Zionodil, used to treat ED, BPH, and PAH.
