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Zembrace SymTouch
Zembrace SymTouch (sumatriptan) is a serotonin receptor agonist (also known as a triptan) used for the acute treatment of migraines, with or without aura, in adults. Zembrace SymTouch is a subcutaneous injection that delivers a rapid dose of sumatriptan to help relieve the headache phase of a migraine attack. Sumatriptan works by narrowing blood vessels in the brain and reducing the release of substances that trigger migraine pain. It is not used to prevent migraines or to treat other types of headaches.
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Frequently Asked Questions
How quickly does Zembrace SymTouch work?
Zembrace SymTouch typically begins to relieve migraine symptoms within 10 to 20 minutes of administration due to its rapid absorption when injected subcutaneously.
Can I use Zembrace SymTouch for cluster headaches?
Zembrace is not approved for the treatment of cluster headaches. Consult your healthcare provider for appropriate treatments for cluster headaches.
What should I do if I don't get relief from the first dose?
If the first dose does not fully relieve your migraine, you can administer a second dose after 1 hour. However, do not exceed four doses (12 mg total) in a 24-hour period.
Can I use Zembrace with other migraine medications?
You should not use Zembrace with other triptans or ergotamine medications. Always inform your healthcare provider of all medications you are taking to avoid potential interactions.
Is Zembrace safe during pregnancy?
Zembrace should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Always consult your healthcare provider if you are pregnant or planning to become pregnant while using Zembrace.
Comprehensive Drug Guide
How Does Zembrace SymTouch Work?
Zembrace SymTouch works by selectively binding to 5-HT1B/1D serotonin receptors in the brain. This action causes the blood vessels around the brain to constrict (narrow), which reduces the pain signals associated with migraine headaches. Sumatriptan also reduces the release of pro-inflammatory neuropeptides that contribute to the pain and other migraine symptoms, such as nausea and light sensitivity.
Common Dosages
- 3 mg subcutaneously, with the option to repeat the dose after 1 hour if the migraine persists.
- Do not exceed 4 doses (12 mg) in a 24-hour period.
Typical Dosing
- For the acute treatment of a migraine, inject 3 mg of Zembrace SymTouch subcutaneously at the onset of the migraine. If the headache returns or is only partially relieved, you may take another dose after at least 1 hour. Do not exceed 12 mg (four doses) in a 24-hour period.
Typical Dosing
FDA Approved Indications
- Zembrace SymTouch is FDA-approved for the acute treatment of migraine attacks in adults, with or without aura. It is not intended for the prevention of migraines or for the treatment of cluster headaches.
Who Shouldn't Take Zembrace SymTouch?
- History of stroke or transient ischemic attack (TIA).
- History of heart attack or coronary artery disease.
- Uncontrolled high blood pressure.
- Severe liver disease.
- Hemiplegic or basilar migraines.
- Allergic reaction to sumatriptan or any of the components of the formulation.
- Peripheral vascular disease or other severe circulation issues.
Advice From The Pharmacist
- Zembrace SymTouch is a self-administered injection, typically injected into the thigh or abdomen. The auto-injector is designed for easy use, but be sure to review the instructions and ask your healthcare provider for a demonstration if needed.
- Use Zembrace at the first sign of a migraine for the best effect. It is not meant to prevent migraines or treat other types of headaches.
- Avoid using more than 4 doses in a 24-hour period. If your migraines are frequent or require frequent dosing, contact your healthcare provider to discuss your treatment plan.
- Keep track of how often you use Zembrace, and report this to your doctor if you need to use it frequently, as this may indicate the need for preventive migraine treatment.
- If you have heart disease or risk factors for heart disease, such as high blood pressure or high cholesterol, your healthcare provider may perform tests to ensure sumatriptan is safe for you to use.
Side Effects of Zembrace SymTouch
Common Side Effects
- Injection site reactions (pain, redness, or swelling)
- Dizziness
- Flushing
- Tingling or numbness
- Tightness in the chest or throat
Uncommon/Severe Side Effects
- Heart attack, chest pain, or irregular heartbeats
- Stroke or other neurological symptoms such as sudden numbness or weakness
- Serotonin syndrome, especially when taken with other serotonergic medications
- Severe allergic reactions (swelling of the face, lips, throat, or tongue)
Risks and Warnings of Zembrace SymTouch
- Cardiovascular Risk: Sumatriptan can cause serious cardiovascular events, including heart attack and stroke, particularly in patients with pre-existing cardiovascular disease or risk factors. If you have a history of heart disease or other risk factors, your doctor may need to assess your heart health before prescribing Zembrace.
- Serotonin Syndrome: Zembrace may increase the risk of serotonin syndrome, especially when used with other serotonergic medications (e.g., SSRIs, SNRIs, MAO inhibitors). Symptoms include agitation, hallucinations, rapid heartbeat, and increased body temperature. Seek immediate medical attention if these symptoms occur.
- Overuse of Migraine Medications: Frequent use of medications like Zembrace can lead to medication overuse headaches (rebound headaches). If you find yourself needing frequent doses, talk to your healthcare provider about preventive options.
Interactions with Zembrace SymTouch
Common Drug Interactions
- SSRIs/SNRIs: These antidepressants (e.g., sertraline, fluoxetine) may increase the risk of serotonin syndrome when used with Zembrace.
- MAO inhibitors: These medications can increase sumatriptan levels in the blood, potentially leading to serious side effects. Zembrace should not be used within 14 days of taking an MAO inhibitor.
- Ergotamine-containing drugs: Combining Zembrace with ergotamine or other triptans can increase the risk of vasospasm and should be avoided.
Alternatives to Zembrace SymTouch
- Other triptans: Such as rizatriptan (Maxalt) or eletriptan (Relpax), which are available in oral and other formulations.
- Dihydroergotamine (DHE 45): A different class of medication used for acute migraine treatment, often administered via nasal spray or injection.
- NSAIDs (nonsteroidal anti-inflammatory drugs): Such as ibuprofen or naproxen, which can provide relief for mild to moderate migraine pain.
- CGRP inhibitors: Such as erenumab (Aimovig) or fremanezumab (Ajovy), which are newer treatments that target a different migraine pathway.
