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Ajovy
Ajovy (generic name: fremanezumab-vfrm) is a monoclonal antibody used to prevent migraines in adults. It belongs to a class of drugs called calcitonin gene-related peptide (CGRP) inhibitors, which work by blocking the activity of the CGRP protein, a molecule that plays a key role in causing migraines. Ajovy is administered as a subcutaneous injection and helps reduce the frequency and severity of migraine attacks, improving the quality of life for those who suffer from chronic or episodic migraines.
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Frequently Asked Questions
How long does it take for Ajovy to start working?
Some patients may notice a reduction in migraine frequency after the first injection, but it may take one to three months of consistent use for full benefits to be observed.
Can I take Ajovy with other migraine medications?
Yes, Ajovy can be used with other acute migraine medications (such as triptans or NSAIDs) as it is designed for prevention, not treatment during an active migraine attack.
How is Ajovy different from other migraine treatments?
Ajovy specifically targets and blocks CGRP, a key protein involved in migraines, offering a preventive approach. Unlike some oral medications, Ajovy is administered via injection, either monthly or quarterly.
What should I do if I miss a dose of Ajovy?
If you miss a dose, take it as soon as you remember and then resume your regular dosing schedule. Do not double doses to make up for a missed injection.
Can Ajovy be self-administered?
Yes, Ajovy can be self-administered after proper training. Your healthcare provider will instruct you on how to use the pre-filled syringe or auto-injector correctly.
Comprehensive Drug Guide
How Does Ajovy Work?
Ajovy works by targeting and blocking the CGRP protein, which is believed to be involved in the dilation of blood vessels in the brain and the transmission of pain signals associated with migraines. By inhibiting CGRP, Ajovy helps to prevent migraine attacks before they start. This mechanism is particularly effective in reducing both the frequency and intensity of migraines.
Common Dosages
- Pre-filled syringe: 225 mg/1.5 mL
- Auto-injector: 225 mg/1.5 mL
Typical Dosing
- Monthly dosing: 225 mg injected once a month.
- Quarterly dosing: 675 mg injected every three months (administered as three consecutive injections of 225 mg).
- Ajovy can be injected by the patient after proper training or administered by a healthcare professional.
Typical Dosing
FDA Approved Indications
- The prevention of migraines in adults (both chronic and episodic)
Who Shouldn't Take Ajovy?
- Hypersensitivity to fremanezumab or any of the ingredients in the formulation
Advice From The Pharmacist
- Store Ajovy in the refrigerator and allow it to reach room temperature before injecting (about 30 minutes).
- Avoid shaking the pre-filled syringe or auto-injector.
- The injection can be given in the abdomen, thigh, or upper arm, rotating injection sites to avoid irritation.
- If a dose is missed, administer it as soon as possible and then resume the regular dosing schedule.
Side Effects of Ajovy
Common Side Effects
- Pain or redness at the injection site
- Constipation
Uncommon/Severe Side Effects
- Severe allergic reactions, such as swelling or difficulty breathing (anaphylaxis)
Risks and Warnings of Ajovy
- Hypersensitivity Reactions: Ajovy may cause serious allergic reactions in some individuals, including anaphylaxis. If you experience swelling, difficulty breathing, or other signs of an allergic reaction, seek medical attention immediately.
- Injection Site Reactions: Some patients may experience pain, swelling, or redness at the injection site, which typically resolves on its own.
Interactions with Ajovy
Common Drug Interactions
- No significant drug interactions have been identified with Ajovy, but it’s important to inform your healthcare provider of all medications and supplements you are taking to avoid potential issues.
Alternatives to Ajovy
- Aimovig (erenumab): Another CGRP inhibitor used for migraine prevention.
- Emgality (galcanezumab): A monoclonal antibody similar to Ajovy, used for preventing migraines and cluster headaches.
- Topiramate: An oral anticonvulsant that is also used for migraine prevention.
- Botox (onabotulinumtoxinA): Injections used to prevent chronic migraines.
