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Emgality
Emgality (galcanezumab-gnlm) is a monoclonal antibody used for the prevention of migraines in adults and for the treatment of episodic cluster headaches. It belongs to a class of drugs known as calcitonin gene-related peptide (CGRP) inhibitors. Emgality helps reduce the frequency of migraine attacks and cluster headaches by blocking the action of CGRP, a protein involved in the transmission of pain signals during migraine episodes.
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Frequently Asked Questions
How quickly does Emgality start working?
Some patients experience fewer migraines within the first month of treatment, but it may take several months for the full effect of Emgality to be realized.
Can Emgality stop a migraine that has already started?
No, Emgality is not used to treat an active migraine. It is intended for migraine prevention.
Can I use Emgality while pregnant?
The safety of Emgality during pregnancy has not been established. If you are pregnant or planning to become pregnant, consult your healthcare provider before using this medication.
How is Emgality different from other migraine treatments?
Emgality specifically targets CGRP, a protein involved in migraines, whereas other treatments like Botox or triptans work through different mechanisms.
Can Emgality be self-administered?
Yes, Emgality is designed to be self-injected at home after proper training by a healthcare provider.
Comprehensive Drug Guide
How Does Emgality Work?
Emgality works by blocking the activity of calcitonin gene-related peptide (CGRP), a protein that plays a key role in the occurrence of migraines and cluster headaches. By inhibiting CGRP, Emgality reduces the inflammation and dilation of blood vessels that contribute to these severe headaches.
Common Dosages
- 120 mg/mL for migraine prevention
- 300 mg (administered as 3 injections of 100 mg) for cluster headaches
Typical Dosing
- For migraine prevention, the typical dose is an initial loading dose of 240 mg (two injections), followed by 120 mg once monthly.
- For episodic cluster headaches, the typical dose is 300 mg administered at the start of the cluster period, then once monthly until the cluster period ends.
Typical Dosing
FDA Approved Indications
- Prevention of migraines in adults
- Treatment of episodic cluster headaches
Who Shouldn't Take Emgality?
- Known hypersensitivity to galcanezumab or any of its components
Advice From The Pharmacist
- Store Emgality in the refrigerator and allow it to reach room temperature before injecting.
- Emgality is injected under the skin (subcutaneous injection), usually in the abdomen or thigh. Rotate injection sites to prevent irritation.
- Keep track of your migraine or cluster headache episodes to help assess the medication’s effectiveness.
Side Effects of Emgality
Common Side Effects
- Injection site reactions (pain, redness, or swelling)
- Constipation
Uncommon/Severe Side Effects
- Hypersensitivity reactions, including swelling of the face, lips, or throat
Risks and Warnings of Emgality
- Allergic Reactions: Serious allergic reactions have been reported, including anaphylaxis. If signs of an allergic reaction occur, such as swelling or difficulty breathing, discontinue use and seek medical help.
- Cardiovascular Concerns: Though rare, patients with cardiovascular conditions should be closely monitored as CGRP inhibitors may affect blood vessel function.
Interactions with Emgality
Common Drug Interactions
- No significant drug interactions are reported with Emgality, but patients should inform their healthcare provider about all medications they are taking, including over-the-counter drugs and supplements.
Alternatives to Emgality
- Aimovig (erenumab-aooe): Another CGRP inhibitor for migraine prevention
- Ajovy (fremanezumab-vfrm): Another CGRP inhibitor for migraine prevention
- Botox (onabotulinumtoxinA): Used for chronic migraine prevention
