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Aimovig
Aimovig (erenumab-aooe) is a monoclonal antibody specifically designed for the preventive treatment of migraines in adults. It is the first medication in a new class of drugs known as CGRP (calcitonin gene-related peptide) antagonists, which work by blocking the action of CGRP, a protein involved in migraine pathophysiology. By inhibiting CGRP, Aimovig helps to reduce the frequency and severity of migraine attacks, providing patients with a valuable tool for migraine management.
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Frequently Asked Questions
How long does it take for Aimovig to start working?
Patients may begin to notice a reduction in migraine frequency within a month of starting Aimovig, but it may take several months to achieve optimal results.
Can I take Aimovig if I have other medical conditions?
Always inform your healthcare provider of any medical conditions you have, as they can help determine if Aimovig is appropriate for you.
What should I do if I miss a dose of Aimovig?
If you miss a dose, administer it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule.
Is Aimovig safe during pregnancy?
Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Aimovig during these periods should be evaluated.
Can I use Aimovig with other migraine treatments?
Yes, Aimovig can be used with other migraine treatments, but it’s important to discuss this with your healthcare provider to ensure safety and effectiveness.
Comprehensive Drug Guide
How Does Aimovig Work?
Aimovig works by selectively binding to the CGRP receptor, blocking the action of CGRP, which is known to promote the development of migraines. By preventing CGRP from exerting its effects, Aimovig reduces the likelihood of migraine attacks and alleviates associated symptoms.
Common Dosages
- Subcutaneous injection: 70 mg and 140 mg prefilled pens or syringes
Typical Dosing
- The recommended starting dose of Aimovig is 70 mg administered subcutaneously once a month. Depending on the patient's response and tolerability, the dose may be increased to 140 mg once a month.
Typical Dosing
FDA Approved Indications
- Migraine in adults
Who Shouldn't Take Aimovig?
- Known hypersensitivity to erenumab or any components of the formulation
Advice From The Pharmacist
- Administer Aimovig as directed by your healthcare provider, ensuring proper injection technique.
- Rotate injection sites to minimize irritation or discomfort at the injection site.
- Monitor for any signs of allergic reactions, such as rash or swelling, and contact your healthcare provider if these occur.
- Keep Aimovig in the refrigerator until use, and allow it to reach room temperature for about 30 minutes before injection.
Side Effects of Aimovig
Common Side Effects
- Injection site reactions (pain, redness, or swelling)
- Constipation
- Muscle spasms
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., rash, itching, swelling, or difficulty breathing)
Risks and Warnings of Aimovig
- Injection Site Reactions: Patients may experience localized reactions at the injection site. Monitoring and proper administration techniques can help mitigate this.
- Constipation: Aimovig can cause constipation in some patients; they should be advised to maintain adequate hydration and dietary fiber intake.
- Allergic Reactions: Be vigilant for any signs of allergic reactions, and seek immediate medical attention if they occur.
Interactions with Aimovig
Common Drug Interactions
- Currently, no significant drug interactions have been identified with Aimovig. However, patients should always inform their healthcare provider of all medications they are taking to avoid potential interactions.
Alternatives to Aimovig
- Other migraine preventive medications: Such as beta-blockers (e.g., propranolol), anticonvulsants (e.g., topiramate), or tricyclic antidepressants.
- CGRP inhibitors: Other medications in the same class, such as fremanezumab or galcanezumab, may be considered for migraine prevention.
- Botox injections: Approved for chronic migraine prevention in adults.
