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Wellbutrin XL
Wellbutrin XL (generic name: bupropion hydrochloride) is an extended-release antidepressant primarily used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). It belongs to a class of medications known as norepinephrine-dopamine reuptake inhibitors (NDRIs), which work by balancing chemicals in the brain that affect mood and emotions. Wellbutrin XL is unique among antidepressants in that it has little to no sexual side effects and can be used to help manage depression in patients who are sensitive to those effects.
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Frequently Asked Questions
How long does it take for Wellbutrin XL to start working?
It may take 2 to 4 weeks to start feeling the effects of Wellbutrin XL. Full improvement of symptoms can take up to 6 to 8 weeks.
Can I take Wellbutrin XL with other antidepressants?
Wellbutrin XL may be used in combination with other antidepressants under the supervision of a healthcare provider, but it should not be taken with other bupropion-containing medications.
Will Wellbutrin XL help me quit smoking?
Wellbutrin XL is not approved for smoking cessation. However, a different form of bupropion called Zyban is prescribed to help people quit smoking.
What should I do if I miss a dose of Wellbutrin XL?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double up on doses to make up for a missed one.
Is Wellbutrin XL safe during pregnancy?
Wellbutrin XL should be used during pregnancy only if the potential benefits outweigh the risks. Consult your healthcare provider if you are pregnant or planning to become pregnant while taking this medication.
Comprehensive Drug Guide
How Does Wellbutrin XL Work?
Wellbutrin XL works by inhibiting the reuptake of norepinephrine and dopamine, two neurotransmitters that play a key role in regulating mood and behavior. By increasing the levels of these neurotransmitters in the brain, Wellbutrin XL helps to alleviate the symptoms of depression, improve mood, and increase energy levels.
Common Dosages
- 150 mg extended-release tablets
- 300 mg extended-release tablets
Typical Dosing
- For major depressive disorder (MDD): The usual starting dose is 150 mg once daily, which may be increased to 300 mg once daily based on the patient's response and tolerability.
- For seasonal affective disorder (SAD): The typical dose is 150 mg once daily, starting in the fall and continuing through early spring. The dose may be increased to 300 mg daily if necessary.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder (MDD)
- Treatment of seasonal affective disorder (SAD)
Who Shouldn't Take Wellbutrin XL?
- A history of seizure disorder or conditions that increase the risk of seizures.
- Known hypersensitivity to bupropion or any of the other ingredients in Wellbutrin XL.
- Eating disorders such as bulimia or anorexia nervosa.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) within the past 14 days.
Advice From The Pharmacist
- Take Wellbutrin XL once daily, preferably in the morning, to reduce the risk of insomnia. Swallow the tablet whole; do not crush or chew it, as this can release the medication too quickly.
- Avoid alcohol while taking Wellbutrin XL, as it can increase the risk of seizures and other side effects.
- It may take several weeks to feel the full effects of Wellbutrin XL, so continue taking it as prescribed even if you don’t notice immediate improvement.
- Do not stop taking Wellbutrin XL suddenly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
Side Effects of Wellbutrin XL
Common Side Effects
- Dry mouth
- Insomnia
- Headache
- Dizziness
- Weight loss
Uncommon/Severe Side Effects
- Seizures
- Increased risk of suicidal thoughts, especially in young adults and adolescents
- High blood pressure
Risks and Warnings of Wellbutrin XL
- Seizure Risk: Wellbutrin XL is associated with an increased risk of seizures, especially at higher doses or in individuals with certain risk factors, such as a history of head trauma or eating disorders.
- Suicidal Thoughts: Like other antidepressants, Wellbutrin XL may increase the risk of suicidal thoughts or behaviors in children, adolescents, and young adults, particularly during the first few months of treatment.
- Hypertension: Wellbutrin XL can cause an increase in blood pressure. Patients with pre-existing hypertension should have their blood pressure monitored regularly.
Interactions with Wellbutrin XL
Common Drug Interactions
- Monoamine Oxidase Inhibitors (MAOIs): Combining Wellbutrin XL with MAOIs can lead to serious and potentially life-threatening interactions. Avoid using these medications together.
- Other bupropion products: Do not take Wellbutrin XL with other forms of bupropion (such as Zyban) to avoid increasing the risk of side effects, including seizures.
- Alcohol: Consuming alcohol while taking Wellbutrin XL may increase the risk of seizures and other side effects. Limit alcohol intake or avoid it altogether.
Alternatives to Wellbutrin XL
- Selective Serotonin Reuptake Inhibitors (SSRIs): Such as Prozac (fluoxetine) or Zoloft (sertraline), commonly prescribed for depression and anxiety.
- Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Such as Effexor XR (venlafaxine) or Cymbalta (duloxetine).
- Mirtazapine (Remeron): An antidepressant that may be effective for individuals with depression who also experience insomnia or loss of appetite.
