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Effexor XR
Effexor XR (venlafaxine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder. By increasing the levels of serotonin and norepinephrine in the brain, Effexor XR helps improve mood, reduce anxiety, and alleviate symptoms associated with depression and anxiety-related conditions.
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Frequently Asked Questions
How long does it take for Effexor XR to start working?
It may take 2 to 4 weeks for Effexor XR to start improving symptoms, though full effects can take several months. Continue taking the medication as prescribed, even if you don't notice immediate results.
Can I stop taking Effexor XR if I feel better?
No, you should not stop taking Effexor XR abruptly. Stopping suddenly can cause withdrawal symptoms such as dizziness, irritability, and nausea. Consult your healthcare provider for a proper tapering schedule.
Can Effexor XR be taken with food?
Yes, Effexor XR can be taken with or without food. Taking it with food may help reduce nausea, which is a common side effect.
What should I do if I miss a dose of Effexor XR?
If you miss a dose, take it as soon as you remember. If it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.
Is Effexor XR safe for long-term use?
Yes, Effexor XR is generally safe for long-term use under the supervision of a healthcare provider. Regular monitoring is recommended to ensure the medication remains effective and that any side effects are managed.
Comprehensive Drug Guide
How Does Effexor XR Work?
Effexor XR works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters that are involved in regulating mood and anxiety. By increasing their levels in the brain, Effexor XR helps alleviate symptoms of depression and anxiety, improving emotional well-being.
Common Dosages
- Capsules: 37.5 mg, 75 mg, 150 mg
Typical Dosing
- For depression and anxiety: The typical starting dose is 75 mg once daily, which may be increased based on the patient’s response. The maximum recommended dose for most conditions is 225 mg daily.
Typical Dosing
FDA Approved Indications
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
- Social anxiety disorder
- Panic disorder
Who Shouldn't Take Effexor XR?
- Known hypersensitivity to venlafaxine or any component of the formulation
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI
Advice From The Pharmacist
- Take Effexor XR exactly as prescribed, usually once daily with or without food. Swallow the capsule whole; do not crush or chew it.
- It may take several weeks for the full effects of Effexor XR to become noticeable. Continue taking the medication as directed, even if you feel better.
- Avoid abruptly stopping Effexor XR, as this can lead to withdrawal symptoms. Always follow your healthcare provider’s guidance when discontinuing the medication.
- If you experience new or worsening depression, mood changes, or thoughts of self-harm, contact your healthcare provider immediately.
Side Effects of Effexor XR
Common Side Effects
- Nausea
- Dizziness
- Insomnia
- Dry mouth
- Sweating
Uncommon/Severe Side Effects
- Increased risk of suicidal thoughts (particularly in young adults)
- Hypertension (increased blood pressure)
- Serotonin syndrome (symptoms like confusion, rapid heart rate, and agitation)
Risks and Warnings of Effexor XR
- Suicidal Thoughts: Effexor XR may increase the risk of suicidal thoughts and behaviors, especially in young adults. Close monitoring by healthcare providers is essential, particularly during the first few months of treatment.
- Hypertension: Effexor XR may cause an increase in blood pressure, particularly at higher doses. Regular monitoring of blood pressure is recommended.
- Serotonin Syndrome: Combining Effexor XR with other medications that increase serotonin (such as SSRIs, SNRIs, or triptans) may lead to serotonin syndrome, a potentially life-threatening condition.
Interactions with Effexor XR
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Effexor XR should not be taken with MAOIs due to the risk of serotonin syndrome.
- Anticoagulants: Effexor XR may increase the risk of bleeding when combined with blood thinners such as warfarin.
- Other serotonergic drugs: Combining Effexor XR with SSRIs, SNRIs, or triptans may increase the risk of serotonin syndrome.
Alternatives to Effexor XR
- Cymbalta (duloxetine): Another SNRI used to treat depression, anxiety, and nerve pain.
- Zoloft (sertraline): An SSRI used for similar conditions such as depression, anxiety, and panic disorders.
- Lexapro (escitalopram): An SSRI often used to treat depression and generalized anxiety disorder.
