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Lexapro
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder and generalized anxiety disorder in adults and adolescents. It helps to improve mood and reduce anxiety by increasing the levels of serotonin, a neurotransmitter, in the brain.
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Frequently Asked Questions
How long does it take for Lexapro to start working?
Patients may begin to notice improvements in symptoms within 1 to 2 weeks, but it can take 4 to 6 weeks for the full effect.
Can I take Lexapro with other medications?
Always consult your healthcare provider before combining Lexapro with other medications to avoid potential interactions.
What should I do if I miss a dose of Lexapro?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Lexapro during pregnancy?
Lexapro should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Lexapro cause weight gain?
Weight gain is a possible side effect of SSRIs, including Lexapro. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Lexapro Work?
Lexapro works by selectively inhibiting the reuptake of serotonin in the brain, which increases the availability of serotonin in the synaptic cleft. This action helps to enhance mood and alleviate symptoms of anxiety.
What is Lexapro Used For?
Lexapro is used to treat Major Depressive Disorder (MDD) & Generalized Anxiety Disorder (GAD).
Common Dosages
Lexapro is typically available in the following formulations:
- Tablets: Common dosages include 10 mg and 20 mg.
- Oral solution: Typically 1 mg/mL.
Typical Dosing
- The usual starting dose for adults is 10 mg once daily, which may be increased to 20 mg once daily after at least one week based on clinical response. For adolescents, the usual starting dose is also 10 mg, with a maximum of 20 mg.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder in adults and adolescents aged 12 years and older.
- Treatment of generalized anxiety disorder in adults.
Off-Label Uses
Obsessive-Compulsive Disorder (OCD): 10 mg once daily, may increase to a maximum of 40mg based on response and tolerability.
Social Anxiety Disorder (SAD): 5mg to 10 mg once daily, titrate slowly to a maximum of 20 mg/day.
Panic Disorder: Initial dose of 5 mg once daily, then increase to 10 mg/day after 7 days, and up to 20 mg if needed.
Post-traumatic Stress Disorder (PTSD): 10 mg once daily, may increase to a maximum of 40mg based on response and tolerability.
Premenstrual Dysphoric Disorder (PMDD): 5mg to 10 mg once daily, may increase to 20 mg if needed.
Who Shouldn't Take Lexapro?
- Known hypersensitivity to escitalopram or any components of the formulation
- Concurrent use of monoamine oxidase inhibitors (MAOIs)
- Use within 14 days of stopping an MAOI
Advice From The Pharmacist
- Patients should be advised to take Lexapro as prescribed and to continue taking it even if they feel well, as it may take several weeks to see the full benefit.
- Discuss the importance of not suddenly discontinuing the medication without consulting a healthcare provider to avoid withdrawal symptoms.
- Encourage patients to report any worsening mood, unusual thoughts, or behavior changes.
Side Effects of Lexapro
Common Side Effects
- Nausea
- Fatigue
- Dry mouth
- Insomnia
- Increased sweating
Uncommon/Severe Side Effects
- Suicidal thoughts or behavior, particularly in young adults
- Serotonin syndrome (symptoms include confusion, hallucination, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering, blurred vision)
Risks and Warnings of Lexapro
- Suicidal Thoughts: Close monitoring is required for patients, especially young adults, during the initial treatment period and when doses are adjusted.
- Serotonin Syndrome: Be aware of symptoms and seek immediate medical attention if they occur.
Interactions with Lexapro
Common Drug Interactions
- Other Antidepressants: Use caution with other SSRIs, SNRIs, and MAOIs to avoid serotonin syndrome.
- Medications That Affect Serotonin: Certain medications (e.g., triptans, certain pain medications) may increase the risk of serotonin syndrome.
Alternatives to Lexapro
- Other Antidepressants: Such as other SSRIs (e.g., fluoxetine, sertraline) or different classes like SNRIs (e.g., venlafaxine).
- Therapy: Cognitive-behavioral therapy (CBT) or other forms of psychotherapy may be beneficial alongside or instead of medication.
