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Cymbalta
Duloxetine is a type of medication known as an antidepressant. This medication is used to treat a range of conditions, such as depression, anxiety, nerve pain, fibromyalgia, and chronic pain. Some common side effects include nausea, dry mouth, and drowsiness, but your healthcare provider will usually make sure the benefits outweigh these issues.
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Frequently Asked Questions
Can I take duloxetine if I have liver disease?
It's not recommended, as duloxetine can be hard on the liver. Always talk to your doctor first.
Will duloxetine cause me to gain weight?
While some people report weight changes while taking duloxetine, it isn't a common side effect. Everyone's body responds differently to medications.
What should I do if I miss a dose?
If you accidentally skip a dose, take it as soon as you can. However, if it's near the time of your next dose, just skip the missed dose. Never double up on a dose.
How long until I start feeling better?
Most people report feeling better after a few weeks. However, everyone is different, so you may feel better sooner or later than this. Always talk to your doctor about your progress.
Can I drink alcohol while taking duloxetine?
It's not recommended, as alcohol can increase the risk of liver damage. It can also add to the side effects of the medication, such as drowsiness and dizziness.
Comprehensive Drug Guide
How Does Cymbalta Work?
Duloxetine is an SSNRI that increases the levels of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
What is Cymbalta Used For?
FDA indications: Duloxetine is used for the management of depression and anxiety, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain.
Off-label uses: It's also been used for stress urinary incontinence, migraine prophylaxis, and more.
Common Dosages
Capsules: 20mg, 30mg, 60mg
Delayed-release capsules: 30mg, 60mg
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Depression and anxiety: 40 to 60mg per day, up to a max of 120mg per day.
- Diabetic peripheral neuropathy: 60mg daily.
- Fibromyalgia: Up to 60mg per day.
- Chronic pain: 30 to 60mg per day.
Off-Label Uses
- For off-label uses:
- Stress urinary incontinence: 40 to 60mg per day.
- Migraine prophylaxis: 60mg per day.
Who Shouldn't Take Cymbalta?
- Those with liver or kidney disease.
- Those with a history of glaucoma.
- Those with a history of bleeding or clotting disorders.
- Those with a history of suicidal thoughts or actions.
- Those with a history of drug abuse or dependence.
- Those who are allergic to duloxetine.
- Those who are taking or have recently taken an MAO inhibitor.
- Those who are breastfeeding, pregnant, or planning to become pregnant.
Advice From The Pharmacist
- Duloxetine can be taken with or without food.
- Avoid drinking alcohol, as it can increase the risk of liver damage.
- Try not to miss any doses. If you miss a dose, take it as soon as possible. But if it's almost time for your next dose, skip the missed dose and continue your regular dosing schedule.
- Duloxetine may elevate your blood pressure. Monitor your blood pressure regularly.
- Do not stop taking duloxetine without talking to your healthcare provider. The dose needs to be reduced gradually to avoid withdrawal symptoms.
- This drug can increase the risk of suicidal thoughts and behaviors in children and young adults. Monitor for mood changes and report any distressing symptoms to a healthcare provider immediately.
Side Effects of Cymbalta
Common Side Effects
- Common:
- Nausea
- Dry mouth
- Constipation
- Reduced appetite
- Fatigue, sleepiness
- Increased sweating.
Uncommon/Severe Side Effects
- Rare:
- Changes in sexual desire
- Abnormal bleeding
- Worsening of depression or anxiety
- Suicidal thoughts.
- Severe side effects:
- Eye pain
- Changes in sexual desire
- Signs of a serious allergic reaction like rash, itching, or swelling of the face/tongue/throat.
Risks and Warnings of Cymbalta
- Suicidal thinking and behavior have been reported in people taking Duloxetine, especially in individuals under 25.
- Patients should monitor their blood pressure regularly while on this drug, as it can raise blood pressure in some people.
- Duloxetine can affect liver function and should be used with caution in individuals with chronic liver disease.
- The use of Duloxetine can lead to skin reactions, like rash or hives. Inform your physician promptly if you experience such reactions.
- It can also affect urination and should thus be used cautiously in patients with a history of urinary problems.
Interactions with Cymbalta
Common Drug Interactions
- MAOIs
- SSRIs
- Certain pain medications
- Certain heart medications
- Some antibiotics
Alternatives to Cymbalta
- SSRIs (fluoxetine, sertraline, citalopram)
- Other SNRIs (venlafaxine, desvenlafaxine)
- Tricyclic antidepressants (amitriptyline, imipramine)
- Pain medications (gabapentin, pregabalin)
