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buPROPion HCl
Bupropion is an antidepressant medication that's often used to treat depression and seasonal affective disorder (SAD). It's also used to promote smoking cessation under the brand name Zyban. Possible side effects include dry mouth, sweating, and an increased heartbeat. The most serious side effects are seizures and allergic reactions, but these are relatively rare.
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Frequently Asked Questions
Can I take bupropion if I have epilepsy?
No, bupropion should generally be avoided in people with a history of seizures or epilepsy.
Does bupropion cause weight gain?
Bupropion is one of the few antidepressants not associated with weight gain. It might even lead to some weight loss.
I missed a dose of bupropion, what should I do?
If you forgot a dose, take it as soon as you remember. But, if it's almost time for your next dose, skip the missed one and continue with your regular schedule.
Will bupropion affect my libido?
Unlike some other antidepressants, bupropion isn't generally linked with a loss of sexual drive. It could even boost libido in some cases!
Can I just stop taking bupropion after I feel better?
Do not stop taking bupropion without consulting with your healthcare provider. Stopping suddenly can cause withdrawal symptoms.
Comprehensive Drug Guide
How Does buPROPion HCl Work?
Bupropion is a monocyclic antidepressant that inhibits neuronal dopamine reuptake, norepinephrine reuptake and selectively inhibits the reuptake of dopamine and norepinephrine, which may lead to increased levels of these neurotransmitters in the synapses, leading to reduced symptoms of depression.
What is buPROPion HCl Used For?
FDA indications: Bupropion is used primarily to treat depressive disorders or prevent a winter-type depression called seasonal affective disorder (SAD). Under the brand name Zyban, it's used to help people stop smoking by decreasing cravings and withdrawal effects.
Off-label uses: It is also used off-label for ADHD, anxiety disorders, and bipolar disorder among others.
Common Dosages
Tablets: 75mg,100mg, 150mg, 200mg, 300mg, 450mg
Oral solution: Not applicable
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Depression: 100 to 450mg per day
- Smoking cessation (Zyban): 150 to 300mg per day
Off-Label Uses
- ADHD: 100 to 450mg per day
- Anxiety disorders: 100 to 300mg per day
- Bipolar disorder: 100 to 450mg per day
Who Shouldn't Take buPROPion HCl?
- Those who have a history of epilepsy or seizure disorders
- People with a recent history of substance use disorders
- Those with eating disorders
- Those diagnosed with bipolar disorder without a mood stabilizer
- Those with certain types of heart disease
- Pregnant women or those planning to become pregnant
- Those with known hypersensitivity or allergy to Bupropion or any of its components
Advice From The Pharmacist
- Do not crush, break, or chew extended-release tablets. Swallow them whole.
- Try not to miss doses. If you?re forgetful, set reminders.
- Don?t stop taking bupropion suddenly. Your doctor will help guide you to taper it off to prevent withdrawal symptoms.
- If you?re feeling any serious symptoms like chest pain, mood changes, or suicidal thoughts, contact a healthcare provider immediately.
- Keep your doctor informed about any side effects or any other medications you?re taking.
- For smoking cessation, start the medication about a week before you plan to quit smoking.
- Lastly, remember to take good care of yourself. Regular exercise, healthy eating, plenty of sleep, and managing stress can have a huge impact on your mental health.
Side Effects of buPROPion HCl
Common Side Effects
- You might feel a dry mouth, shakiness, and increased sweating.
- Difficulty sleeping, headaches, or dizziness might also occur.
Uncommon/Severe Side Effects
- Rare side effects:
- You might experience a seizure (fit).
- Severe side effects:
- Suicidal thoughts, allergies, fever, chest pain, or palpitations are signs of a serious situation and should be reported immediately.
Risks and Warnings of buPROPion HCl
- Caution should be exercised in patients with a history of bipolar disorder, as bupropion can trigger manic/psychotic episodes.
- Individuals with seizure disorders, or conditions that predispose them to seizures (e.g., brain damage, alcohol addiction, bulimia), should avoid this drug due to its potential to lower seizure threshold.
- Abruptly stopping the use of alcohol or sedatives can increase the risk of seizures when taking bupropion.
- Individuals with liver or kidney problems, or hypertension, should use this drug under close medical surveillance.
- Suicidal thoughts or behaviors should be monitored in youth and in patients where depression or other psychiatric illness is present.
Interactions with buPROPion HCl
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other antidepressants
- Antipsychotics
- Certain high blood pressure medications
- Certain heart medications
Alternatives to buPROPion HCl
- Fluoxetine
- Sertraline
- Paroxetine
- Duloxetine
- Escitalopram
