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Wellbutrin SR
Wellbutrin SR (generic name: bupropion hydrochloride) is a sustained-release antidepressant used to treat major depressive disorder (MDD) and to help with smoking cessation in some cases. It belongs to a class of medications known as norepinephrine-dopamine reuptake inhibitors (NDRIs), which help balance chemicals in the brain that affect mood and behavior. Wellbutrin SR is often favored due to its lower risk of sexual side effects compared to other antidepressants.
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Frequently Asked Questions
How long does it take for Wellbutrin SR to start working?
Wellbutrin SR may take 2 to 4 weeks to start relieving symptoms of depression. Full improvement can take up to 6 to 8 weeks.
Can I take Wellbutrin SR with other antidepressants?
Yes, Wellbutrin SR can be combined with other antidepressants under a healthcare provider’s supervision, but it should not be taken with other forms of bupropion.
Will Wellbutrin SR help me quit smoking?
Yes, the active ingredient in Wellbutrin SR is the same as in Zyban, which is used to help people quit smoking by reducing cravings and withdrawal symptoms.
What should I do if I miss a dose of Wellbutrin SR?
If you miss a dose, take it as soon as you remember unless it’s close to your next dose. Do not take two doses at once to make up for a missed dose.
Is Wellbutrin SR safe during pregnancy?
Wellbutrin SR should be used during pregnancy only if the potential benefits outweigh the risks. Consult your healthcare provider if you are pregnant or planning to become pregnant while taking this medication.
Comprehensive Drug Guide
How Does Wellbutrin SR Work?
Wellbutrin SR works by inhibiting the reuptake of norepinephrine and dopamine, two key neurotransmitters involved in mood regulation. By increasing the levels of these neurotransmitters in the brain, Wellbutrin SR helps alleviate the symptoms of depression, improve mood, and increase energy levels. It also reduces nicotine cravings and withdrawal symptoms in individuals trying to quit smoking.
Common Dosages
- 100 mg sustained-release tablets
- 150 mg sustained-release tablets
- 200 mg sustained-release tablets
Typical Dosing
- For major depressive disorder (MDD): The typical starting dose is 150 mg once daily for the first three days, then increased to 150 mg twice daily if tolerated. The maximum recommended dose is 400 mg per day.
- For smoking cessation: The typical dose is 150 mg once daily for the first three days, then increased to 150 mg twice daily, starting one week before the quit date.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder (MDD)
- Smoking cessation (marketed under the brand name Zyban)
Who Shouldn't Take Wellbutrin SR?
- A history of seizure disorders
- Known hypersensitivity to bupropion or any other components of the medication
- Eating disorders such as bulimia or anorexia nervosa
- Concurrent use of monoamine oxidase inhibitors (MAOIs) within the past 14 days
Advice From The Pharmacist
- Take Wellbutrin SR at least 8 hours apart to reduce the risk of seizures. Swallow the tablet whole—do not crush, chew, or break it, as this may increase the risk of side effects.
- Avoid alcohol while taking Wellbutrin SR, as it may increase the risk of seizures and other side effects.
- Do not stop taking Wellbutrin SR suddenly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- It may take several weeks to feel the full effects of Wellbutrin SR, so continue taking it as prescribed even if you don’t notice immediate improvement.
Side Effects of Wellbutrin SR
Common Side Effects
- Dry mouth
- Insomnia
- Headache
- Dizziness
- Weight loss
Uncommon/Severe Side Effects
- Seizures
- Increased risk of suicidal thoughts, especially in young adults and adolescents
- Hypertension (high blood pressure)
Risks and Warnings of Wellbutrin SR
- Seizure Risk: Wellbutrin SR increases the risk of seizures, especially at higher doses or in individuals with certain risk factors such as a history of head trauma or alcohol use.
- Suicidal Thoughts: Antidepressants like Wellbutrin SR may increase the risk of suicidal thoughts, particularly in young adults and adolescents during the first few months of treatment.
- Blood Pressure: Wellbutrin SR can cause high blood pressure, particularly in individuals with a history of hypertension. Blood pressure should be monitored regularly.
Interactions with Wellbutrin SR
Common Drug Interactions
- Monoamine Oxidase Inhibitors (MAOIs): Combining Wellbutrin SR with MAOIs can result in serious and potentially life-threatening interactions. Avoid using these medications together.
- Alcohol: Consuming alcohol while taking Wellbutrin SR can increase the risk of seizures and other side effects.
- Other bupropion-containing medications: Avoid taking Wellbutrin SR with other forms of bupropion, such as Zyban, to prevent overdose and increased risk of side effects.
Alternatives to Wellbutrin SR
- Selective Serotonin Reuptake Inhibitors (SSRIs): Such as Zoloft (sertraline) or Prozac (fluoxetine), commonly used to treat depression and anxiety.
- Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Such as Effexor XR (venlafaxine) or Cymbalta (duloxetine).
- Mirtazapine (Remeron): An antidepressant that may be effective for individuals with depression and insomnia.
