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VESIcare LS
VESIcare LS (generic name: solifenacin succinate) is an anticholinergic medication used to treat overactive bladder (OAB) in children aged 2 years and older. Overactive bladder is characterized by frequent urination, urgency, and incontinence (leakage of urine). VESIcare LS works by relaxing the bladder muscles, helping to reduce the urgency and frequency of urination and prevent accidental leaks.
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Frequently Asked Questions
How long does it take for VESIcare LS to start working?
VESIcare LS may start improving symptoms of overactive bladder within a few days, but it can take up to a few weeks for full effects to be noticeable.
Can VESIcare LS be used long-term?
Yes, VESIcare LS is designed for long-term use in managing overactive bladder symptoms. However, regular follow-up with your healthcare provider is important to monitor the medication’s effectiveness and manage any side effects.
Can VESIcare LS cause drowsiness in children?
Yes, drowsiness is a potential side effect, although not all children experience it. Monitor your child for signs of drowsiness or confusion, and avoid activities requiring alertness (such as riding a bike) if they seem affected.
What should I do if I miss a dose of VESIcare LS?
If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to make up for the missed one.
Is VESIcare LS safe for my child?
VESIcare LS is FDA-approved for use in children aged 2 years and older for treating overactive bladder. Your healthcare provider will assess the benefits and monitor for any potential side effects to ensure the medication is safe and effective for your child.
Comprehensive Drug Guide
How Does VESIcare LS Work?
VESIcare LS works by blocking muscarinic receptors in the bladder, which reduces the involuntary contractions of the bladder muscle. This helps to increase bladder capacity, reduce feelings of urgency, and decrease episodes of urinary incontinence or frequent urination.
Common Dosages
- 1 mg/mL oral suspension
Typical Dosing
- For children aged 2 years and older: The recommended starting dose is 2 mg (2 mL) once daily, which may be increased to 3 mg (3 mL) or 4 mg (4 mL) once daily depending on the patient’s response and tolerance.
- The dose can be adjusted by your healthcare provider based on the child’s weight and symptom control.
Typical Dosing
FDA Approved Indications
- Treatment of overactive bladder (OAB) in pediatric patients aged 2 years and older, which includes symptoms of urgency, frequency, and urinary incontinence.
Who Shouldn't Take VESIcare LS?
- Urinary retention (inability to urinate)
- Severe gastrointestinal conditions (e.g., toxic megacolon)
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to solifenacin succinate or any components of the formulation
Advice From The Pharmacist
- Shake the bottle well before each dose to ensure the medication is evenly mixed.
- Administer VESIcare LS once daily at the same time each day, with or without food.
- Use the provided dosing syringe to measure the correct dose of the oral suspension. If you do not have the syringe, contact your pharmacist for a replacement.
- Ensure the medication is kept out of reach of children and stored at room temperature. Do not freeze the suspension.
Side Effects of VESIcare LS
Common Side Effects
- Dry mouth
- Constipation
- Drowsiness
- Blurry vision
- Urinary retention
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Severe constipation or bowel obstruction
- Severe urinary retention (inability to urinate)
Risks and Warnings of VESIcare LS
- Risk of Urinary Retention: VESIcare LS can cause urinary retention, especially in patients with existing bladder outlet obstruction. Patients should be monitored for the ability to urinate normally.
- Cognitive Effects: Anticholinergic medications like VESIcare LS may cause drowsiness, confusion, or blurred vision. Monitor for signs of mental or cognitive changes, especially in children.
- Constipation: This is a common side effect, and severe cases can lead to bowel obstruction. Ensure your child stays hydrated and eats a fiber-rich diet to help prevent constipation.
Interactions with VESIcare LS
Common Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): These drugs can increase the levels of solifenacin in the blood, increasing the risk of side effects.
- Other anticholinergic medications (e.g., diphenhydramine): Combining with other anticholinergics can increase the risk of dry mouth, constipation, and confusion.
- Medications for glaucoma: VESIcare LS can exacerbate symptoms in patients with narrow-angle glaucoma.
Alternatives to VESIcare LS
- Oxybutynin (Ditropan): Another anticholinergic agent used to treat overactive bladder in both adults and pediatric patients.
- Tolterodine (Detrol): Another medication used to treat overactive bladder, working similarly to solifenacin but with a different side effect profile.
- Mirabegron (Myrbetriq): A beta-3 adrenergic agonist used to treat overactive bladder in adults and children aged 3 years and older.
