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Myrbetriq
Myrbetriq (generic name: mirabegron) is a beta-3 adrenergic agonist used for the treatment of overactive bladder (OAB) with symptoms such as urgency, frequency, and urge incontinence. It works by relaxing the bladder muscle, increasing the storage capacity of the bladder.
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Frequently Asked Questions
How quickly does Myrbetriq work?
Patients may start to notice improvements in symptoms within 8 to 12 weeks of starting treatment.
Can I take Myrbetriq with food?
Yes, Myrbetriq can be taken with or without food; however, maintain consistency in how you take it for optimal results.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Myrbetriq?
There are no specific dietary restrictions, but maintaining a healthy diet is advisable for overall bladder health.
Is Myrbetriq safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Myrbetriq, as its safety during these periods is not fully established.
Comprehensive Drug Guide
How Does Myrbetriq Work?
Myrbetriq works by stimulating beta-3 adrenergic receptors in the bladder, leading to relaxation of the detrusor muscle during the storage phase of the urinary bladder fill cycle. This action helps increase bladder capacity and reduce the frequency of contractions.
Common Dosages
- Extended-Release Tablets: 25 mg and 50 mg.
Typical Dosing
- The usual starting dose for adults is 25 mg once daily, which may be increased to 50 mg once daily based on individual response and tolerability.
Typical Dosing
FDA Approved Indications
- Overactive Bladder: for the treatment of OAB with symptoms of urgency, frequency, and urge incontinence.
Who Shouldn't Take Myrbetriq?
- Known hypersensitivity to mirabegron or any component of the formulation.
- Severe uncontrolled hypertension.
Advice From The Pharmacist
- Take Myrbetriq exactly as prescribed, typically once daily, with or without food.
- Monitor blood pressure regularly, especially during the first few weeks of treatment.
- Be aware of potential side effects, and report any severe reactions to your healthcare provider.
Side Effects of Myrbetriq
Common Side Effects
- Increased blood pressure
- Nasopharyngitis (common cold)
- Urinary tract infection
- Headache
- Constipation
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Worsening hypertension.
Risks and Warnings of Myrbetriq
- Hypertension: Myrbetriq can increase blood pressure; monitor regularly and adjust treatment as needed.
- Bladder Outlet Obstruction: Use caution in patients with bladder outlet obstruction or urinary retention.
Interactions with Myrbetriq
Common Drug Interactions
- Other Antihypertensive Medications: May require monitoring and adjustment due to potential increases in blood pressure.
- Medications Metabolized by CYP2D6: Mirabegron may affect the metabolism of drugs processed by this enzyme.
Alternatives to Myrbetriq
- Anticholinergic Medications: Such as oxybutynin or tolterodine for similar indications in managing overactive bladder.
- Lifestyle Modifications: Behavioral therapies and bladder training may also be recommended.
