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VESIcare
VESIcare, the brand name for solifenacin succinate, is a medication used to treat symptoms of overactive bladder (OAB), such as frequent urination, urgency, and urge incontinence (leakage). VESIcare belongs to a class of drugs known as anticholinergics, which work by relaxing the muscles in the bladder, reducing the need to urinate and helping control bladder function. This can significantly improve the quality of life for individuals dealing with an overactive bladder.
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Frequently Asked Questions
How long does it take for VESIcare to start working?
It may take several weeks of consistent use before you notice significant improvements in overactive bladder symptoms. Some patients may experience symptom relief within 2 weeks.
Can VESIcare be taken with food?
Yes, VESIcare can be taken with or without food. It is important to take it at the same time each day for the best results.
Can I stop taking VESIcare if my symptoms improve?
You should not stop taking VESIcare without consulting your healthcare provider, even if your symptoms improve. Stopping the medication may cause symptoms to return.
What should I do if I miss a dose of VESIcare?
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your next dose at the regular time. Do not double up on doses.
Can VESIcare cause weight gain?
Weight gain is not a common side effect of VESIcare. However, the medication can cause constipation and bloating in some patients, which may result in temporary weight fluctuations.
Comprehensive Drug Guide
How Does VESIcare Work?
VESIcare works by blocking muscarinic receptors in the bladder. These receptors are responsible for controlling bladder muscle contractions. By blocking them, VESIcare helps to relax the bladder muscle, which reduces the urgency to urinate, increases bladder capacity, and helps prevent involuntary contractions that lead to urgency and leakage.
Common Dosages
- 5 mg tablets
- 10 mg tablets
Typical Dosing
- The typical starting dose of VESIcare is 5 mg once daily, taken with or without food.
- For patients who tolerate the 5 mg dose and need additional symptom control, the dose may be increased to 10 mg once daily, depending on the patient's response and tolerance.
Typical Dosing
FDA Approved Indications
- Overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Who Shouldn't Take VESIcare?
- Urinary retention (inability to empty the bladder)
- Severe gastric retention (delayed stomach emptying)
- Uncontrolled narrow-angle glaucoma
- Severe liver impairment
- Known hypersensitivity to solifenacin or any of the components in the formulation
Advice From The Pharmacist
- Take VESIcare once daily, at the same time each day, with or without food.
- Swallow the tablets whole with water; do not crush, chew, or break them.
- Stay hydrated, as VESIcare can cause dry mouth, and drinking plenty of water may help reduce this side effect.
- Avoid overheating or becoming dehydrated, as VESIcare may reduce your ability to sweat, increasing the risk of heatstroke.
- If you experience difficulty urinating, severe stomach pain, or blurred vision, contact your healthcare provider immediately, as these may be signs of serious side effects.
Side Effects of VESIcare
Common Side Effects
- Dry mouth
- Constipation
- Blurred vision
- Drowsiness
- Dry eyes
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Urinary retention (inability to empty the bladder)
- Severe constipation
- Increased intraocular pressure in patients with glaucoma
- Cognitive changes (such as confusion or hallucinations)
Risks and Warnings of VESIcare
- Urinary retention: VESIcare can cause or worsen urinary retention, which may require medical intervention. Patients with a history of urinary retention or bladder outlet obstruction should use this medication with caution.
- Gastrointestinal issues: VESIcare can cause or worsen constipation, and in some cases, severe constipation may lead to complications such as intestinal blockage. Patients with gastrointestinal disorders should be monitored carefully.
- Narrow-angle glaucoma: VESIcare can increase intraocular pressure, potentially worsening narrow-angle glaucoma. Patients with a history of glaucoma should use VESIcare with caution.
- Cognitive effects: Some anticholinergic medications, including VESIcare, may cause confusion, memory loss, or hallucinations, especially in elderly patients.
Interactions with VESIcare
Common Drug Interactions
- Other anticholinergics: Using VESIcare with other anticholinergic medications (such as benztropine or diphenhydramine) may increase the risk of side effects such as dry mouth, constipation, and blurred vision.
- CYP3A4 inhibitors: Medications that inhibit CYP3A4 enzymes, such as ketoconazole, itraconazole, and clarithromycin, can increase the levels of VESIcare in the blood, raising the risk of side effects. Dose adjustments may be necessary.
- Medications that cause urinary retention: Drugs like opioids and tricyclic antidepressants may increase the risk of urinary retention when used with VESIcare.
Alternatives to VESIcare
- Oxybutynin (Ditropan): Another anticholinergic used to treat overactive bladder symptoms.
- Tolterodine (Detrol): An anticholinergic medication commonly prescribed for overactive bladder.
- Mirabegron (Myrbetriq): A beta-3 adrenergic agonist that relaxes the bladder muscle and is used as an alternative to anticholinergics for OAB.
- Trospium (Sanctura): Another anticholinergic used for OAB, with fewer central nervous system side effects.
- Behavioral therapy: Bladder training, pelvic floor exercises, and dietary changes are non-drug alternatives for managing overactive bladder symptoms.
