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Vaseretic
Vaseretic is a combination medication containing Enalapril Maleate (an ACE inhibitor) and Hydrochlorothiazide (a diuretic, or water pill). It is primarily prescribed to treat high blood pressure (hypertension). Enalapril works by relaxing blood vessels to help lower blood pressure, while hydrochlorothiazide helps reduce excess fluid in the body by increasing urine output. Together, these two medications help reduce blood pressure and prevent complications such as strokes, heart attacks, and kidney problems.
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Frequently Asked Questions
Can I stop taking Vaseretic if my blood pressure improves?
No, do not stop taking Vaseretic without consulting your healthcare provider, even if your blood pressure improves. Stopping suddenly may lead to a rebound in high blood pressure.
How long does it take for Vaseretic to work?
It may take a few weeks for the full effects of Vaseretic to be felt. However, you may notice some blood pressure reduction within the first few days.
Can I take Vaseretic with other blood pressure medications?
Yes, Vaseretic can be taken with other blood pressure medications if prescribed by your doctor. It is often used in combination therapy to achieve better blood pressure control.
What should I do if I miss a dose?
If you miss a dose of Vaseretic, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double up doses.
Can Vaseretic cause weight gain?
Weight gain is not a common side effect of Vaseretic. However, if you notice unusual weight changes, especially with swelling or fluid retention, contact your doctor.
Comprehensive Drug Guide
How Does Vaseretic Work?
- Enalapril: As an ACE inhibitor, enalapril blocks the action of the enzyme that produces angiotensin II, a substance that causes blood vessels to constrict. By preventing this, enalapril helps to relax and widen blood vessels, lowering blood pressure.
- Hydrochlorothiazide: This diuretic reduces the amount of water and salt absorbed by the kidneys, thereby reducing blood volume and helping to lower blood pressure.
Common Dosages
- 5 mg/12.5 mg (Enalapril 5 mg / Hydrochlorothiazide 12.5 mg)
- 10 mg/25 mg (Enalapril 10 mg / Hydrochlorothiazide 25 mg)
Typical Dosing
- The usual starting dose for Vaseretic is 1 tablet daily, with the dosage adjusted as needed to achieve desired blood pressure control. The dosage depends on individual patient response and any underlying health conditions.
Typical Dosing
FDA Approved Indications
- Hypertension (High Blood Pressure)
It is used when blood pressure control is not adequately achieved with enalapril or hydrochlorothiazide alone.
Who Shouldn't Take Vaseretic?
- Known hypersensitivity to enalapril, hydrochlorothiazide, or other sulfonamide-derived drugs
- Angioedema related to previous ACE inhibitor use
- Severe kidney impairment
- Patients with anuria (inability to produce urine)
- Pregnancy, as ACE inhibitors can cause injury or death to the developing fetus
Advice From The Pharmacist
- Vaseretic should be taken as prescribed, usually once a day in the morning to avoid frequent urination at night due to the diuretic effect of hydrochlorothiazide.
- Make sure to stay hydrated, but be mindful of over-hydrating, as this can reduce the effectiveness of the diuretic component.
- Avoid taking Vaseretic with alcohol, as this can increase the risk of dizziness or fainting due to a drop in blood pressure.
- Regular monitoring of blood pressure and kidney function is important while taking Vaseretic.
- This medication may increase sensitivity to sunlight, so use sunscreen and wear protective clothing when outdoors.
Side Effects of Vaseretic
Common Side Effects
- Dizziness or lightheadedness, especially when standing up
- Cough (due to enalapril)
- Increased urination
- Fatigue
- Muscle cramps
Uncommon/Severe Side Effects
- Severe allergic reactions, such as angioedema (swelling of the face, lips, tongue, or throat)
- Signs of kidney problems, such as a change in urine output
- Severe dizziness or fainting
- Electrolyte imbalances, such as low potassium or sodium levels
Risks and Warnings of Vaseretic
- Angioedema: Vaseretic can cause swelling (angioedema), particularly in patients with a history of angioedema. Discontinue the medication immediately if swelling occurs.
- Electrolyte Imbalance: Hydrochlorothiazide can cause an imbalance of electrolytes, such as potassium or sodium. Regular blood tests may be required to monitor these levels.
- Pregnancy Warning: Vaseretic should not be used during pregnancy, as ACE inhibitors can cause fetal harm. Women of childbearing age should use effective contraception while taking this medication.
- Kidney Function: Patients with impaired kidney function need close monitoring, as Vaseretic can affect kidney performance, especially due to the ACE inhibitor component.
Interactions with Vaseretic
Common Drug Interactions
- Potassium supplements or potassium-sparing diuretics (e.g., spironolactone) can increase the risk of hyperkalemia (high potassium levels).
- NSAIDs (e.g., ibuprofen) can reduce the effectiveness of Vaseretic and increase the risk of kidney problems.
- Lithium: Vaseretic can increase lithium levels, potentially leading to toxicity.
- Alcohol: Drinking alcohol can increase the blood pressure-lowering effect of Vaseretic, leading to excessive dizziness or fainting.
Alternatives to Vaseretic
- Lotensin HCT (benazepril and hydrochlorothiazide): Another ACE inhibitor combined with a thiazide diuretic for hypertension.
- Hyzaar (losartan and hydrochlorothiazide): A combination of an angiotensin II receptor blocker (ARB) and a diuretic, often used as an alternative for patients who cannot tolerate ACE inhibitors.
- Zestoretic (lisinopril and hydrochlorothiazide): A combination ACE inhibitor and diuretic, similar to Vaseretic.
- Amlodipine and hydrochlorothiazide: A combination of a calcium channel blocker and a diuretic.
