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Lotensin HCT
Lotensin HCT is a combination medication that includes benazepril, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide (HCT), a thiazide diuretic. It is primarily used to treat hypertension (high blood pressure). This combination works synergistically to lower blood pressure more effectively than either agent alone.
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Frequently Asked Questions
Other Combination Medications: Such as lisinopril and hydrochlorothiazide or other combinations for hypertension management. Monotherapy: Either benazepril or hydrochlorothiazide alone for patients who may not tolerate combination therapy.
Patients may start to see improvements in their blood pressure within a few days, but optimal control may take several weeks.
Can I take Lotensin HCT with food?
Lotensin HCT can be taken with or without food; however, consistency in how you take it is recommended.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while taking Lotensin HCT?
There are no specific dietary restrictions, but reducing sodium intake is generally advisable for hypertension management.
Is Lotensin HCT safe during pregnancy or breastfeeding?
Lotensin HCT is contraindicated during pregnancy. Consult your healthcare provider if you are breastfeeding to discuss the risks and benefits of using Lotensin HCT.
Comprehensive Drug Guide
How Does Lotensin HCT Work?
- Benazepril works by inhibiting the enzyme that converts angiotensin I to angiotensin II, a powerful vasoconstrictor. By blocking this action, benazepril helps relax blood vessels and lowers blood pressure.
- Hydrochlorothiazide promotes the excretion of sodium and water through urine, which decreases blood volume and further lowers blood pressure.
Common Dosages
- Benazepril 10 mg/Hydrochlorothiazide 12.5 mg
- Benazepril 20 mg/Hydrochlorothiazide 12.5 mg
- Benazepril 20 mg/Hydrochlorothiazide 25 mg
Typical Dosing
- The usual starting dose is one tablet once daily, which may be adjusted based on blood pressure response.
Typical Dosing
FDA Approved Indications
- Hypertension: treatment of high blood pressure in adults.
Who Shouldn't Take Lotensin HCT?
- Known hypersensitivity to benazepril, hydrochlorothiazide, or any component of the formulation.
- A history of angioedema related to previous ACE inhibitor treatment.
- Severe renal impairment or electrolyte imbalance.
Advice From The Pharmacist
- Take Lotensin HCT at the same time each day to maintain even blood levels.
- Monitor your blood pressure regularly to assess the effectiveness of the medication.
- Be aware of signs of hypotension, especially after the first dose or dose increases.
Side Effects of Lotensin HCT
Common Side Effects
- Dizziness
- Fatigue
- Cough (less common with benazepril compared to other ACE inhibitors)
- Swelling (edema)
Uncommon/Severe Side Effects
- Angioedema (swelling of the face, lips, tongue, or throat)
- Severe allergic reactions (rash, itching, swelling)
- Low blood pressure (hypotension)
Risks and Warnings of Lotensin HCT
- Cardiovascular Risk: Monitor for symptoms of heart failure, especially in patients with a history of heart problems.
- Electrolyte Imbalance: Regular monitoring of potassium and renal function is advised, particularly in patients at risk for electrolyte disturbances.
- Pregnancy: Lotensin HCT is contraindicated during pregnancy due to potential harm to the fetus.
Interactions with Lotensin HCT
Common Drug Interactions
- Diuretics: May enhance the hypotensive effect; monitor blood pressure closely.
- Other Antihypertensives: Caution is advised when combining with other blood pressure-lowering medications.
- NSAIDs: Can reduce the effectiveness of ACE inhibitors and increase the risk of renal impairment.
Alternatives to Lotensin HCT
- Other Combination Medications: Such as lisinopril and hydrochlorothiazide or other combinations for hypertension management.
- Monotherapy: Either benazepril or hydrochlorothiazide alone for patients who may not tolerate combination therapy.
