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Ubrelvy
Ubrelvy, the brand name for ubrogepant, is an oral medication used to treat acute migraine with or without aura in adults. It belongs to a class of drugs known as CGRP receptor antagonists, which work by blocking the action of a protein called calcitonin gene-related peptide (CGRP). CGRP plays a role in the development of migraine symptoms, including pain and sensitivity to light and sound. Ubrelvy is designed for use during a migraine attack to relieve symptoms and improve function, but it is not intended to prevent migraines.
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Frequently Asked Questions
How long does it take for Ubrelvy to start working?
Ubrelvy can start relieving migraine symptoms within 1 to 2 hours after taking the medication. For some patients, it may take longer to feel the full effects.
Can I take a second dose of Ubrelvy if my migraine returns?
Yes, you can take a second dose at least 2 hours after the first dose if your migraine persists or returns. However, do not exceed 200 mg (two 100 mg doses) in a 24-hour period.
Can Ubrelvy be used to prevent migraines?
No, Ubrelvy is not approved for the prevention of migraines. It is designed to treat acute migraine attacks as they occur.
Can I take Ubrelvy with other migraine medications?
You should avoid taking Ubrelvy with other CGRP inhibitors or triptans unless directed by your healthcare provider. However, Ubrelvy can be used in combination with other medications like NSAIDs or antiemetics.
What should I do if I miss a dose of Ubrelvy?
Ubrelvy is taken on an as-needed basis for migraine relief, so there is no regular dosing schedule. Take it at the onset of migraine symptoms. If your symptoms improve, there is no need to take additional doses.
Comprehensive Drug Guide
How Does Ubrelvy Work?
Ubrelvy works by blocking the CGRP receptor, which prevents the binding of CGRP to its receptor. CGRP is a protein that causes inflammation and the dilation of blood vessels in the brain, contributing to migraine pain. By blocking CGRP, Ubrelvy helps reduce the intensity of migraine symptoms, including pain, nausea, and sensitivity to light and sound.
Common Dosages
- 50 mg tablets
- 100 mg tablets
Typical Dosing
- The typical dose for Ubrelvy is 50 mg or 100 mg, taken as needed at the onset of a migraine.
- If symptoms persist after the first dose, a second dose can be taken at least 2 hours after the first dose.
- The maximum dose in a 24-hour period is 200 mg (i.e., two 100 mg doses).
Typical Dosing
FDA Approved Indications
- Acute treatment of migraine with or without aura in adults.
It is not approved for the prevention of migraines or for treating cluster headaches.
Who Shouldn't Take Ubrelvy?
- Severe liver impairment (Child-Pugh Class C)
- End-stage renal disease
- Known hypersensitivity to ubrogepant or any component of the formulation
Advice From The Pharmacist
- Take Ubrelvy as soon as possible after the onset of migraine symptoms. It is not intended to prevent migraines or to be taken on a regular schedule.
- You can take Ubrelvy with or without food. Avoid grapefruit or grapefruit juice, as they can increase the levels of Ubrelvy in the blood, raising the risk of side effects.
- If a second dose is needed, wait at least 2 hours after the first dose. Do not exceed 200 mg in a 24-hour period.
- Ubrelvy can be used in combination with other acute migraine treatments, such as NSAIDs or antiemetics, but it should not be used with other CGRP inhibitors or triptans without consulting your healthcare provider.
- If you experience serious allergic reactions, such as swelling of the face, lips, or throat, or difficulty breathing, seek medical attention immediately.
Side Effects of Ubrelvy
Common Side Effects
- Nausea
- Fatigue or drowsiness
- Dry mouth
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, rash, difficulty breathing)
Risks and Warnings of Ubrelvy
- Liver or kidney impairment: Ubrelvy should be used cautiously in patients with moderate liver or kidney impairment, as it is primarily metabolized by the liver and excreted through the kidneys. Dose adjustments may be required in these patients.
- Grapefruit interaction: Grapefruit and grapefruit juice can increase the levels of ubrogepant in the blood, raising the risk of side effects. Avoid grapefruit products while using Ubrelvy.
- Allergic reactions: Although rare, serious allergic reactions can occur. Stop taking Ubrelvy and seek medical attention if you experience symptoms such as swelling, rash, or difficulty breathing.
Interactions with Ubrelvy
Common Drug Interactions
- CYP3A4 inhibitors: Strong inhibitors of the CYP3A4 enzyme, such as ketoconazole, clarithromycin, or itraconazole, can increase the concentration of Ubrelvy in the blood, raising the risk of side effects. Dose adjustments may be needed.
- CYP3A4 inducers: Medications that induce CYP3A4, such as rifampin or carbamazepine, can reduce the effectiveness of Ubrelvy by decreasing its levels in the blood.
- Grapefruit and grapefruit juice: These should be avoided, as they can increase Ubrelvy levels in the blood.
Alternatives to Ubrelvy
- Rimegepant (Nurtec ODT): Another CGRP receptor antagonist used for the acute treatment of migraines and also approved for migraine prevention.
- Triptans (sumatriptan, rizatriptan): A class of medications commonly used to treat acute migraines. They work by constricting blood vessels, unlike CGRP inhibitors.
- NSAIDs (ibuprofen, naproxen): Nonsteroidal anti-inflammatory drugs can be used to relieve migraine pain in some patients.
- Antiemetics (metoclopramide): Used to control nausea and vomiting associated with migraines.
