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Trilipix

Trilipix, the brand name for fenofibric acid, is a fibrate medication used to help manage high cholesterol and high triglycerides in patients with dyslipidemia. It is often prescribed alongside lifestyle changes, such as diet and exercise, to lower low-density lipoprotein (LDL) cholesterol, total cholesterol, triglycerides, and to increase high-density lipoprotein (HDL) cholesterol. Trilipix is sometimes used in combination with statins to provide additional lipid-lowering benefits.

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Frequently Asked Questions

How long does it take for Trilipix to start working?
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Trilipix can start lowering cholesterol and triglycerides within a few weeks of starting the medication, but full effects may take several months to be seen. Regular blood tests will help monitor progress.

Can I take Trilipix with statins?
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Yes, Trilipix is often used in combination with statins to provide additional lipid-lowering benefits. However, there is an increased risk of muscle damage when these drugs are combined, so regular monitoring is essential.

What should I do if I miss a dose of Trilipix?
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If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take your next dose as scheduled. Do not double up on doses.

Can Trilipix cause weight gain?
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Weight gain is not a common side effect of Trilipix. However, if you experience significant changes in weight, you should discuss this with your healthcare provider.

Is Trilipix safe for long-term use?
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Trilipix is generally safe for long-term use when monitored regularly by a healthcare provider. Regular blood tests are required to ensure liver function and lipid levels remain within the desired range.

Comprehensive Drug Guide

How Does Trilipix Work?

Trilipix works by activating peroxisome proliferator-activated receptor alpha (PPAR-alpha), which increases the breakdown and clearance of triglycerides from the blood. It also helps lower LDL cholesterol by enhancing the liver's ability to remove cholesterol from the body. Additionally, Trilipix increases HDL cholesterol, the "good" cholesterol that helps remove excess cholesterol from the arteries.

Common Dosages

  • 45 mg delayed-release capsules
  • 135 mg delayed-release capsules

Typical Dosing

  • The typical starting dose for Trilipix is 135 mg once daily, taken with or without food.
  • In patients with renal impairment, the recommended dose is 45 mg once daily.
  • Dose adjustments may be required based on lipid levels and individual response to treatment.

Typical Dosing

FDA Approved Indications

  • Hypertriglyceridemia: To lower high triglycerides.
  • Mixed dyslipidemia: To lower LDL cholesterol, total cholesterol, and triglycerides, and to increase HDL cholesterol in adults.
  • Adjunct therapy: Used alongside statins for patients with high cholesterol and triglycerides.

Who Shouldn't Take Trilipix?

  • Severe liver disease
  • Severe kidney disease
  • Gallbladder disease
  • Known hypersensitivity to fenofibric acid or any component of the formulation
  • Nursing mothers (breastfeeding)

Advice From The Pharmacist

  • Take Trilipix once daily, at the same time each day, with or without food.
  • Continue a healthy diet and exercise program while taking Trilipix to maximize its benefits.
  • Avoid drinking alcohol while on Trilipix, as it can increase triglyceride levels and reduce the effectiveness of the medication.
  • Regular blood tests are necessary to monitor cholesterol levels and liver function. Notify your healthcare provider if you experience unusual symptoms, such as muscle pain or weakness, as this may indicate a serious side effect.
  • Do not stop taking Trilipix without consulting your healthcare provider, as this can lead to a return of high cholesterol or triglyceride levels.

Side Effects of Trilipix

Common Side Effects

  • Abdominal pain
  • Nausea or vomiting
  • Headache
  • Diarrhea
  • Muscle pain

Uncommon/Severe Side Effects

  • Myopathy (muscle pain, tenderness, or weakness)
  • Liver damage (jaundice, dark urine)
  • Gallstones
  • Pancreatitis (severe abdominal pain, nausea)

Risks and Warnings of Trilipix

  • Myopathy and rhabdomyolysis: Trilipix may increase the risk of muscle damage, especially when used with statins. Patients should report any muscle pain, tenderness, or weakness to their healthcare provider.
  • Liver damage: Trilipix can cause liver enzyme elevations. Regular monitoring of liver function tests is required, and the drug should be discontinued if significant liver damage is detected.
  • Gallstones: Trilipix can increase the risk of gallstones, particularly in patients with a history of gallbladder disease. If you experience severe abdominal pain, contact your healthcare provider immediately.
  • Renal impairment: Patients with kidney problems may require dose adjustments or more frequent monitoring, as Trilipix can exacerbate kidney issues.

Interactions with Trilipix

Common Drug Interactions

  • Statins: When used in combination with statins (such as atorvastatin or rosuvastatin), the risk of muscle damage and rhabdomyolysis increases. Careful monitoring is required.
  • Anticoagulants (warfarin): Trilipix can increase the effects of warfarin, raising the risk of bleeding. Regular monitoring of blood clotting times (INR) is recommended.
  • Immunosuppressants (cyclosporine): Combining Trilipix with cyclosporine can increase the risk of kidney damage. Close monitoring of kidney function is required.
  • Bile acid sequestrants: If taken with cholestyramine or other bile acid sequestrants, Trilipix should be administered at least 1 hour before or 4 to 6 hours after to avoid interference with absorption.

Alternatives to Trilipix

  • Fenofibrate (Tricor): Another fibrate used to lower cholesterol and triglycerides, similar to Trilipix.
  • Gemfibrozil (Lopid): Another fibrate that can be used to lower high triglycerides, but with a higher risk of muscle toxicity when combined with statins.
  • Niacin: A vitamin B3 supplement that can help lower cholesterol and triglycerides, though it may cause side effects like flushing.
  • Omega-3 fatty acids (fish oil): Supplements that can help lower triglyceride levels, often used alongside other medications for cholesterol management.