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Toujeo SoloStar
Toujeo SoloStar is a long-acting insulin glargine used to manage type 1 and type 2 diabetes mellitus in adults. It helps control blood sugar levels by providing a steady, continuous release of insulin over a 24-hour period. Toujeo SoloStar is designed for once-daily subcutaneous injections and is available in a pre-filled insulin pen that contains 300 units/mL of insulin glargine. It offers the same active ingredient as Lantus (insulin glargine), but in a more concentrated form, making it suitable for patients who need higher doses of insulin.
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Frequently Asked Questions
How long does it take for Toujeo SoloStar to start working?
Toujeo SoloStar starts working within a few hours after injection, but its full effects are typically seen after several days of consistent use, as it is designed to provide long-lasting basal insulin coverage.
Can I use Toujeo SoloStar if I am pregnant?
Toujeo SoloStar may be used during pregnancy if the benefits outweigh the risks, but it should only be taken under the guidance of a healthcare provider. Proper blood sugar control is crucial during pregnancy to avoid complications.
How should I store my Toujeo SoloStar pen?
Unopened pens should be stored in the refrigerator. Once in use, they can be kept at room temperature and should be used or discarded within 6 weeks.
Can I take Toujeo SoloStar with other diabetes medications?
Yes, Toujeo SoloStar can be combined with other diabetes medications, such as metformin or other oral drugs. However, close monitoring of blood sugar levels is necessary to avoid hypoglycemia.
What should I do if I miss a dose of Toujeo SoloStar?
If you miss a dose, take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose. Do not double the dose to make up for the missed one.
Comprehensive Drug Guide
How Does Toujeo SoloStar Work?
Toujeo SoloStar works by providing a steady release of insulin to help regulate blood sugar levels throughout the day and night. Insulin glargine mimics the body’s natural basal insulin, helping the body absorb glucose from the bloodstream and prevent the liver from producing excess glucose. This helps keep blood sugar levels stable between meals and overnight.
Common Dosages
- Pre-filled pen: 300 units/mL (1.5 mL per pen)
Typical Dosing
- Adults: The dose of Toujeo SoloStar is individualized based on the patient’s needs and blood glucose levels. Typically, it is administered once daily at the same time each day.
- Starting dose: For patients switching from another long-acting insulin (like Lantus), the initial dose is often the same unit-for-unit dose as the previous insulin, but may be adjusted based on response and blood sugar levels.
Typical Dosing
FDA Approved Indications
- Type 1 diabetes mellitus in adults who require long-acting insulin.
- Type 2 diabetes mellitus in adults to improve glycemic control in cases where oral medications or other diabetes treatments are not sufficient.
Who Shouldn't Take Toujeo SoloStar?
- Hypoglycemia
- Known hypersensitivity to insulin glargine or any components of the formulation.
Advice From The Pharmacist
- Toujeo SoloStar should be injected subcutaneously in areas such as the abdomen, thigh, or upper arm. Always rotate injection sites to avoid skin reactions.
- Do not mix Toujeo SoloStar with other insulins or use it in an insulin pump.
- Store unopened pens in the refrigerator, but once in use, they can be kept at room temperature for up to 6 weeks.
- Monitor blood sugar regularly and adjust the dose according to your doctor’s recommendations.
- If you experience symptoms of low blood sugar (such as shakiness, sweating, or confusion), treat it immediately by consuming fast-acting sugar.
Side Effects of Toujeo SoloStar
Common Side Effects
- Hypoglycemia (low blood sugar)
- Injection site reactions (redness, swelling, or irritation)
- Weight gain
Uncommon/Severe Side Effects
- Severe hypoglycemia, which can lead to fainting, confusion, or seizures.
- Allergic reactions, including difficulty breathing or swelling of the face, lips, or tongue.
Risks and Warnings of Toujeo SoloStar
- Hypoglycemia: Toujeo SoloStar can cause dangerously low blood sugar, especially if taken in excess or combined with other diabetes medications without proper monitoring.
- Hypokalemia: Insulin can lower potassium levels, which may lead to serious heart problems. Monitoring potassium levels is important for patients at risk of hypokalemia.
- Dosage Errors: Because Toujeo is more concentrated than other insulin formulations, it is important to measure doses carefully to avoid overdose.
Interactions with Toujeo SoloStar
Common Drug Interactions
- Oral diabetes medications: Combining Toujeo SoloStar with sulfonylureas or other oral diabetes drugs can increase the risk of hypoglycemia.
- Beta-blockers: These can mask the symptoms of low blood sugar, making it harder to detect hypoglycemia.
- Alcohol: Drinking alcohol while on insulin can cause unpredictable blood sugar fluctuations, increasing the risk of both low and high blood sugar episodes.
Alternatives to Toujeo SoloStar
- Lantus (insulin glargine 100 units/mL): A lower-concentration version of insulin glargine for patients who need smaller doses of insulin.
- Levemir (insulin detemir): Another long-acting insulin that provides blood sugar control for up to 24 hours.
- Tresiba (insulin degludec): An ultra-long-acting insulin that lasts over 24 hours and provides more flexibility in dosing time.
- Basaglar (insulin glargine): A biosimilar insulin to Lantus, used for the same purpose but may be more cost-effective for some patients.
