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Tresiba
Tresiba, the brand name for insulin degludec, is a long-acting basal insulin used to control blood sugar levels in individuals with diabetes mellitus, including both type 1 and type 2 diabetes. Tresiba helps maintain a stable level of insulin over an extended period, typically for 24 hours or longer, reducing the need for multiple daily injections. It is usually taken once daily and is designed to provide consistent blood sugar control throughout the day and night.
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Frequently Asked Questions
How long does it take for Tresiba to start working?
Tresiba starts working within 1 to 2 hours of injection and lasts for over 24 hours. It provides consistent blood sugar control with once-daily dosing.
Can I take Tresiba with other insulin?
Tresiba should not be mixed with other insulins in the same syringe. However, it can be used alongside rapid-acting insulin for meal-time blood sugar control, especially in patients with type 1 diabetes.
What should I do if I miss a dose of Tresiba?
If you miss a dose of Tresiba, take it as soon as you remember, but ensure at least 8 hours have passed before your next scheduled dose. Consult your healthcare provider for further instructions if needed.
Can Tresiba cause weight gain?
Yes, some patients may experience weight gain while using Tresiba. This is common with insulin therapy, as it helps the body store glucose more efficiently.
How long can I store Tresiba pens after opening them?
After opening, Tresiba pens can be stored at room temperature for up to 8 weeks. Unopened pens should be stored in the refrigerator until use.
Comprehensive Drug Guide
How Does Tresiba Work?
Tresiba works by mimicking the action of natural insulin, helping the body regulate blood sugar levels. It provides a steady release of insulin over 24 hours or more, allowing glucose to be absorbed by cells for energy and preventing high blood sugar levels (hyperglycemia). Tresiba has a long duration of action, which means it helps control blood sugar levels for an extended period with a once-daily injection.
Common Dosages
- 100 units/mL (U-100)
- 200 units/mL (U-200)
The exact dosage varies based on individual needs, blood sugar levels, and response to insulin therapy. It is administered once daily at any time of day, but it should be taken at the same time each day for consistency.
Typical Dosing
- Type 1 diabetes: The usual starting dose is approximately one-third to one-half of the total daily insulin dose, with the remainder given as rapid-acting insulin around meals.
- Type 2 diabetes: The typical starting dose is 10 units once daily, but it may be adjusted based on blood sugar monitoring and individual response.
Doses are adjusted regularly based on blood sugar readings and other factors determined by the healthcare provider.
Typical Dosing
FDA Approved Indications
- Type 1 diabetes mellitus in adults and children.
- Type 2 diabetes mellitus in adults and children.
Who Shouldn't Take Tresiba?
- Hypersensitivity to insulin degludec or any components of the formulation.
- Hypoglycemia (low blood sugar) at the time of injection.
Advice From The Pharmacist
- Administer Tresiba once daily at the same time each day, either in the abdomen, thigh, or upper arm. Rotate injection sites to avoid lipodystrophy (fat deposits at the injection site).
- Always monitor blood sugar levels regularly, especially when starting or adjusting your insulin dose.
- If you miss a dose, take it as soon as you remember. However, if it’s too close to your next dose, skip the missed dose and resume your normal schedule. Do not double up on doses.
- Do not mix Tresiba with other insulins or inject it into the same site as other insulin formulations.
- Store unopened Tresiba pens or vials in the refrigerator. Once opened, they can be stored at room temperature for up to 8 weeks.
- Carry a glucose source (like glucose tablets or juice) to treat any episodes of hypoglycemia.
Side Effects of Tresiba
Common Side Effects
- Hypoglycemia (low blood sugar), which can cause symptoms such as dizziness, sweating, shakiness, confusion, and irritability.
- Injection site reactions (redness, swelling, or irritation)
- Weight gain
- Edema (swelling in the legs or feet)
Uncommon/Severe Side Effects
- Severe hypoglycemia: If blood sugar drops too low, it can cause loss of consciousness, seizures, or coma.
- Allergic reactions: Signs include swelling, rash, itching, or difficulty breathing.
Risks and Warnings of Tresiba
- Hypoglycemia: Tresiba, like all insulins, carries a risk of low blood sugar. Monitoring blood sugar levels regularly is essential, and patients should always have a source of fast-acting glucose on hand in case of low blood sugar.
- Weight gain: Some patients may experience weight gain when taking Tresiba, as it helps the body store glucose as fat.
- Hypersensitivity reactions: Serious allergic reactions, including anaphylaxis, are rare but possible. Stop using Tresiba and seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, or severe rash.
- Insulin adjustments: Changes in insulin needs can occur with changes in physical activity, diet, stress, illness, or other medications. Regular communication with your healthcare provider is important to manage insulin needs.
Interactions with Tresiba
Common Drug Interactions
- Oral diabetes medications: Tresiba may be used alongside oral medications for type 2 diabetes, but dose adjustments may be necessary.
- Beta-blockers: These medications can mask the signs of hypoglycemia, such as fast heartbeat, making it harder to detect low blood sugar.
- Alcohol: Alcohol can increase the risk of hypoglycemia, especially if consumed in large amounts or on an empty stomach.
- Corticosteroids: These medications may increase blood sugar levels, requiring insulin dose adjustments.
Alternatives to Tresiba
- Lantus (insulin glargine): Another long-acting insulin used for blood sugar control.
- Levemir (insulin detemir): A long-acting insulin that works similarly to Tresiba but may need to be taken twice daily in some patients.
- Toujeo (insulin glargine U-300): A long-acting insulin with a higher concentration that provides steady blood sugar control.
- Basaglar (insulin glargine): A biosimilar to Lantus, used for long-acting blood sugar control.
