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Insulin Glargine
Insulin glargine is a type of insulin used to control high blood sugar in adults and children with diabetes mellitus. It's a long-acting insulin that helps your body use sugar properly and keeps your blood sugar stable throughout the day and night. Some common side effects include hypoglycemia (low blood sugar), weight gain, and an allergic reaction at the injection site, but your healthcare provider will ensure the benefits outweigh these issues.
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Frequently Asked Questions
Can I stop taking insulin glargine when my blood sugar is under control?
No. Insulin glargine is a long-term diabetes treatment, and it helps to keep your blood sugar levels stable. Consult your healthcare provider if you're considering stopping this medication.
Does insulin glargine cause weight gain?
Yes, weight gain can be a side effect of insulin glargine. Eating a balanced diet and regular exercise can help to control this.
I have missed a dose of insulin glargine, what should I do?
If you're close to your next dose, skip the missed one. If not, inject it as soon as you remember. Don't double doses.
Does insulin glargine cause hypoglycemia?
Yes, taking too much insulin glargine can cause low blood sugar (hypoglycemia). If you experience symptoms of hypoglycemia, such as shakiness, dizziness, sweating, or confusion, call your healthcare provider right away.
Can insulin glargine be used in pregnancy?
Insulin glargine is classified as pregnancy category C. This means that it is not known whether insulin glargine will harm an unborn baby. It is always important to consult your healthcare provider if you are pregnant or planning to conceive.
Comprehensive Drug Guide
How Does Insulin Glargine Work?
Insulin Glargine is an analog of human insulin that has been modified to have a longer duration of action and a relatively flat activity profile. The activity of insulin prevents high blood glucose levels (hyperglycemia), which can lead to serious health complications.
What is Insulin Glargine Used For?
FDA indications: Insulin Glargine is used to treat both Type 1 and Type 2 diabetes. It?s often used in combination with other short-acting insulin or oral antidiabetic drugs.
Off-label uses: It's occasionally used off-label for the treatment of gestational diabetes.
Common Dosages
Injection solution: 100 Units/mL, 300 Units/mL
Typical Dosing
FDA Approved Indications
- The dosage of insulin glargine will depend upon your individual needs, your response to treatment, and the goal of therapy. The average dosage usually falls within the range of 0.2-0.4 Units/kilogram per day.
Who Shouldn't Take Insulin Glargine?
- People who're allergic to insulin glargine or any of its ingredients.
- Patients with hypersensitivity to the active substance or any of the excipients.
- Patients with episodes of hypoglycemia.
Advice From The Pharmacist
- Insulin glargine is usually administered once daily at the same time each day.
- Carefully monitor your blood glucose levels, developing an action plan if your levels drop too much.
- Don't mix or dilute insulin glargine with any other insulin or solution.
- Injection site rotation is important. Don't use the same site for each injection.
Side Effects of Insulin Glargine
Common Side Effects
- Hypoglycemia (low blood sugar)
- Weight gain
- An allergic reaction at the injection site
Uncommon/Severe Side Effects
- Rare side effects:
- Hypersensitivity or allergic reaction characterized by difficulty breathing, shortness of breath, rapid pulse, and sweating.
- Severe side effects:
- Signs of hypoglycemia include confusion, shakiness, and unconsciousness.
- If you notice any serious side effects, consult a healthcare professional immediately.
Risks and Warnings of Insulin Glargine
- Insulin Glargine must be used with caution in subjects with hypokalemia, as hypoglycemia or hypokalemia may occur.
- Dose adjustments and close glucose level monitoring are essential in patients with kidney or liver impairment.
- Patients must be educated to recognize and manage hypoglycemia, which is a common side effect.
- Abrupt discontinuation or dose reduction can lead to hyperglycemia and, in cases of type 1 diabetes, ketoacidosis.
- It's unknown if insulin glargine causes harm to unborn babies; therefore, it should be used during pregnancy only if needed.
Interactions with Insulin Glargine
Common Drug Interactions
- Antidiabetic agents
- Beta-blockers
- Diuretics
- Glucocorticoids
- Sympathomimetic agents
Alternatives to Insulin Glargine
- Insulin Detemir
- Insulin Degludec
- NPH insulin
