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Tekturna HCT
Tekturna HCT is a combination medication containing aliskiren (a direct renin inhibitor) and hydrochlorothiazide (a thiazide diuretic). It is used to treat high blood pressure (hypertension). Aliskiren works by inhibiting the action of renin, an enzyme that leads to the narrowing of blood vessels, while hydrochlorothiazide helps the body eliminate excess salt and water through urine. This combination reduces blood pressure by both relaxing blood vessels and reducing the volume of blood.
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Frequently Asked Questions
How long does it take for Tekturna HCT to lower blood pressure?
Tekturna HCT usually starts lowering blood pressure within 1 to 2 weeks of starting treatment, but it may take up to 4 weeks to see the full effect.
Can Tekturna HCT be taken with food?
Yes, Tekturna HCT can be taken with or without food, but it’s recommended to avoid high-fat meals, as they can reduce the absorption of aliskiren.
What should I do if I miss a dose?
If you miss a dose of Tekturna HCT, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take the next dose at your regular time. Do not double up to make up for a missed dose.
Can I take Tekturna HCT during pregnancy?
No, Tekturna HCT should not be used during pregnancy, especially in the second and third trimesters, as it can cause harm or death to the developing fetus.
Is Tekturna HCT a first-line treatment for hypertension?
Tekturna HCT is generally used when other medications alone do not adequately control blood pressure, making it a second-line or combination therapy for managing hypertension.
Comprehensive Drug Guide
How Does Tekturna HCT Work?
- Aliskiren works by directly inhibiting renin, an enzyme produced by the kidneys that regulates blood pressure and fluid balance. By blocking renin, aliskiren reduces the production of angiotensin II, which normally causes blood vessels to constrict, thereby lowering blood pressure.
- Hydrochlorothiazide helps lower blood pressure by reducing fluid retention. It increases the excretion of sodium and water through the kidneys, which decreases blood volume and in turn reduces blood pressure.
Common Dosages
- 150 mg/12.5 mg
- 150 mg/25 mg
- 300 mg/12.5 mg
- 300 mg/25 mg
Typical Dosing
- The usual starting dose is 150 mg/12.5 mg once daily. The dose may be increased to 300 mg/25 mg once daily based on the patient's response and blood pressure control.
Typical Dosing
FDA Approved Indications
- Treatment of hypertension to lower blood pressure in adults, particularly when a single-agent therapy has not been sufficient.
Who Shouldn't Take Tekturna HCT?
- Known hypersensitivity to aliskiren, hydrochlorothiazide, or sulfonamide-derived drugs.
- Severe kidney impairment or inability to produce urine (anuria).
- Pregnancy: Use during pregnancy can cause harm or death to the developing fetus. Discontinue use as soon as pregnancy is detected.
- Concomitant use with ACE inhibitors or ARBs in patients with diabetes due to the risk of kidney problems, hyperkalemia, and hypotension.
Advice From The Pharmacist
- Take Tekturna HCT at the same time each day, with or without food, but avoid high-fat meals, as they can reduce the absorption of aliskiren.
- Stay hydrated while taking Tekturna HCT, as hydrochlorothiazide can cause dehydration and electrolyte imbalances.
- Avoid potassium supplements or salt substitutes containing potassium without consulting your healthcare provider, as aliskiren can increase potassium levels in the blood.
- Monitor blood pressure regularly, and attend follow-up appointments to assess kidney function and electrolyte levels, especially if you are taking other medications that affect the kidneys or potassium levels.
- If you experience swelling in the face, lips, tongue, or throat (angioedema), seek medical help immediately, as this is a serious side effect of aliskiren.
Side Effects of Tekturna HCT
Common Side Effects
- Dizziness or lightheadedness
- Diarrhea
- Fatigue
- Headache
- Cough
Uncommon/Severe Side Effects
- Angioedema (swelling of the face, lips, tongue, or throat)
- Kidney problems, especially in patients with pre-existing kidney conditions
- Hyperkalemia (high potassium levels)
- Severe dehydration or electrolyte imbalances, such as low sodium or low potassium levels
- Severe allergic reactions, such as rash, itching, or difficulty breathing
Risks and Warnings of Tekturna HCT
- Angioedema Risk: Tekturna HCT can cause angioedema, a serious condition characterized by swelling of the face, lips, tongue, or throat, which can be life-threatening if it leads to difficulty breathing. Discontinue use immediately if angioedema occurs.
- Hyperkalemia: Aliskiren can increase potassium levels in the blood, which can lead to dangerous heart problems. Regular blood tests may be required to monitor potassium levels, especially if you are taking other medications that raise potassium.
- Kidney Problems: Patients with a history of kidney disease should be closely monitored, as Tekturna HCT can worsen kidney function, particularly when combined with other medications that affect kidney function.
- Electrolyte Imbalances: Hydrochlorothiazide can cause imbalances in electrolytes, such as low potassium, sodium, or magnesium. Symptoms of electrolyte imbalances include muscle weakness, cramps, irregular heartbeats, or confusion.
- Pregnancy: Tekturna HCT should not be used during pregnancy. It can cause harm or death to the developing fetus, particularly in the second and third trimesters.
Interactions with Tekturna HCT
Common Drug Interactions
- ACE inhibitors or ARBs: Using Tekturna HCT with ACE inhibitors or ARBs (like lisinopril or losartan) in patients with diabetes can increase the risk of kidney damage, hyperkalemia, and hypotension.
- Potassium supplements: Avoid potassium supplements or potassium-containing salt substitutes, as they can increase the risk of hyperkalemia when combined with Tekturna HCT.
- NSAIDs: Nonsteroidal anti-inflammatory drugs (like ibuprofen or naproxen) can reduce the effectiveness of Tekturna HCT and increase the risk of kidney problems.
- Lithium: Hydrochlorothiazide can increase lithium levels, leading to lithium toxicity.
Alternatives to Tekturna HCT
- Lisinopril-HCTZ: A combination of an ACE inhibitor and a diuretic used to treat hypertension.
- Losartan-HCTZ: A combination of an angiotensin receptor blocker (ARB) and a diuretic, used for high blood pressure.
- Amlodipine/Benazepril (Lotrel): A combination of a calcium channel blocker and an ACE inhibitor.
- Valsartan-HCTZ: An ARB-diuretic combination used to treat high blood pressure.
