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Lotrel

Lotrel is a combination medication that includes amlodipine, a calcium channel blocker, and benazepril, an angiotensin-converting enzyme (ACE) inhibitor. It is primarily used to treat hypertension (high blood pressure). The combination of these two medications works synergistically to lower blood pressure more effectively than either agent alone.

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Frequently Asked Questions

How long does it take for Lotrel to lower blood pressure?
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Patients may start to see improvements in blood pressure within a few days, but optimal control may take several weeks.

Can I take Lotrel with food?
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Lotrel can be taken with or without food; consistency is key for effective management.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while taking Lotrel?
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There are no specific dietary restrictions, but reducing sodium intake is generally advisable for hypertension management.

Is Lotrel safe during pregnancy or breastfeeding?
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Lotrel is contraindicated during pregnancy. Consult your healthcare provider if you are breastfeeding to discuss the risks and benefits of using Lotrel.

Comprehensive Drug Guide

How Does Lotrel Work?

  • Amlodipine works by relaxing the blood vessels, which allows for easier blood flow and reduces blood pressure.
  • Benazepril inhibits the conversion of angiotensin I to angiotensin II, a substance that narrows blood vessels. By blocking this process, benazepril helps to relax blood vessels and decrease blood pressure.


Common Dosages

  • 2.5 mg/10 mg
  • 5 mg/10 mg
  • 5 mg/20 mg
  • 10 mg/20 mg

Typical Dosing

  • The usual starting dose is one tablet taken once daily, which may be adjusted based on blood pressure response.


Typical Dosing

FDA Approved Indications

  • Hypertension: treatment of high blood pressure in adults.


Who Shouldn't Take Lotrel?

  • Known hypersensitivity to amlodipine, benazepril, or any component of the formulation.
  • History of angioedema related to previous ACE inhibitor treatment.
  • Severe renal impairment or aortic stenosis.


Advice From The Pharmacist

  • Take Lotrel at the same time each day to maintain even blood levels.
  • Monitor your blood pressure regularly to assess the effectiveness of the medication.
  • Be aware of signs of hypotension (e.g., dizziness, lightheadedness) especially after the first dose or dosage increases.


Side Effects of Lotrel

Common Side Effects

  • Swelling (edema)
  • Dizziness
  • Fatigue
  • Flushing
  • Headache


Uncommon/Severe Side Effects

  • Angioedema (swelling of the face, lips, tongue, or throat)
  • Severe allergic reactions (rash, itching)
  • Low blood pressure (hypotension)


Risks and Warnings of Lotrel

  • Cardiovascular Risk: Monitor for symptoms of heart failure, especially in patients with a history of heart problems.
  • Kidney Function: Regular monitoring of renal function is advised, particularly in patients with existing renal issues.
  • Pregnancy: Lotrel is contraindicated during pregnancy due to potential harm to the fetus.


Interactions with Lotrel

Common Drug Interactions

  • Diuretics: May enhance the hypotensive effect; monitor blood pressure closely.
  • Other Antihypertensives: Caution is advised when combining with other blood pressure-lowering medications.
  • NSAIDs: Can reduce the effectiveness of ACE inhibitors and increase the risk of renal impairment.


Alternatives to Lotrel

  • Other Combination Medications: Such as lisinopril and amlodipine or other combinations for hypertension management.
  • Monotherapy: Either amlodipine or benazepril alone for patients who may not tolerate combination therapy.