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Sympazan
Sympazan (generic name: clobazam) is an oral film formulation used to treat seizures associated with Lennox-Gastaut syndrome (LGS), a severe form of childhood epilepsy. Clobazam is a benzodiazepine, which helps control seizures by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that has calming effects on the brain. Sympazan is an orally dissolving film designed for patients who have difficulty swallowing tablets or capsules.
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Frequently Asked Questions
How long does it take for Sympazan to work?
Sympazan begins to work within 30 to 60 minutes after administration, and its effects can last for several hours. However, it may take several days or weeks for the full therapeutic effects to be observed in managing seizures.
Can Sympazan be taken with food?
Sympazan can be taken with or without food. It is best to follow the healthcare provider’s instructions regarding the timing of administration.
What should I do if I miss a dose?
If you miss a dose of Sympazan, take it as soon as you remember, unless it is close to the time of your next scheduled dose. Do not double up on doses to make up for the missed one.
Can Sympazan be used in children?
Yes, Sympazan is approved for use in children aged 2 years and older who have seizures associated with Lennox-Gastaut syndrome.
Can Sympazan cause weight gain?
Weight gain is not a common side effect of Sympazan, but some patients may experience changes in appetite or metabolism. If you notice significant changes in weight, consult your healthcare provider.
Comprehensive Drug Guide
How Does Sympazan Work?
Clobazam works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that helps calm nerve activity in the brain. By boosting GABA activity, clobazam helps reduce the frequency and severity of seizures in individuals with Lennox-Gastaut syndrome.
Common Dosages
- 5 mg, 10 mg, and 20 mg oral film
Typical Dosing
- The typical starting dose for seizures associated with Lennox-Gastaut syndrome is 5 mg once daily for the first week, which may be increased based on the patient's weight and response to treatment. For higher doses, the film may be increased to 10 mg or 20 mg as directed by the healthcare provider.
Typical Dosing
FDA Approved Indications
- Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years and older.
Who Shouldn't Take Sympazan?
- Hypersensitivity to clobazam or other benzodiazepines.
- Severe liver impairment, as clobazam is metabolized by the liver.
- Acute narrow-angle glaucoma.
Advice From The Pharmacist
- Place the Sympazan film on your tongue and allow it to dissolve. Do not chew or swallow the film whole, as it is designed to dissolve in the mouth.
- Take Sympazan as prescribed, as missing doses or stopping the medication abruptly can increase the risk of withdrawal symptoms and seizure recurrence.
- Avoid alcohol while taking Sympazan, as it can enhance the sedative effects of clobazam and increase the risk of drowsiness, dizziness, or impaired coordination.
- Be cautious when driving or operating heavy machinery, as Sympazan can cause drowsiness and affect coordination.
- Do not stop Sympazan abruptly without consulting your healthcare provider, as it may increase the risk of withdrawal symptoms or worsening seizures. The medication should be tapered off gradually under medical supervision.
Side Effects of Sympazan
Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Coordination problems (ataxia)
- Drooling
- Constipation
Uncommon/Severe Side Effects
- Respiratory depression, especially when used in combination with opioids or other central nervous system depressants.
- Severe allergic reactions, including rash, swelling, or difficulty breathing.
- Withdrawal symptoms, which can occur if the medication is stopped abruptly. Symptoms include anxiety, insomnia, tremors, and seizures.
- Mood or behavior changes, including aggression, irritability, or suicidal thoughts.
Risks and Warnings of Sympazan
- Dependence and Withdrawal: Sympazan, like other benzodiazepines, can cause physical dependence if used for a prolonged period. Abruptly stopping the medication can lead to withdrawal symptoms, including seizures, anxiety, and tremors. Patients should be tapered off the medication gradually under a healthcare provider's guidance.
- Sedation and Respiratory Depression: Sympazan can cause sedation and, in severe cases, respiratory depression, especially when taken with opioids, alcohol, or other central nervous system depressants.
- Behavioral and Mood Changes: Some patients may experience mood changes, including aggression, irritability, or suicidal thoughts. Any significant changes in behavior should be reported to a healthcare provider immediately.
- Impaired Coordination: Sympazan may cause coordination problems (ataxia), increasing the risk of falls, particularly in elderly patients.
Interactions with Sympazan
Common Drug Interactions
- Opioids: Combining Sympazan with opioids (e.g., morphine, hydrocodone) can increase the risk of respiratory depression and sedation.
- CNS depressants: Medications that depress the central nervous system, such as alcohol, sleep aids, or muscle relaxants, can enhance the sedative effects of Sympazan.
- Antiepileptic drugs (e.g., phenytoin, carbamazepine): These medications can affect the metabolism of clobazam and may require dose adjustments.
- St. John’s Wort: This herbal supplement may reduce the effectiveness of clobazam by increasing its metabolism.
Alternatives to Sympazan
- Onfi (Clobazam tablets): An oral tablet form of clobazam used to treat seizures in patients with Lennox-Gastaut syndrome.
- Epidiolex (Cannabidiol): A prescription medication used for treating seizures associated with Lennox-Gastaut syndrome.
- Valproic acid (Depakote): An antiepileptic drug commonly used to treat various types of seizures.
- Lamotrigine (Lamictal): Another antiepileptic medication used to manage seizures, including those associated with Lennox-Gastaut syndrome.
