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Valproic Acid
Valproic acid is an anti-seizure medication also used to treat bipolar disorder and prevent migraines. It works by restoring the natural balance of certain substances in the brain. Common side effects may include nausea, dizziness, or drowsiness. But the benefits usually outweigh these minor annoyances.
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Frequently Asked Questions
Can I drink alcohol while using Valproic Acid?
It is advised to limit alcohol consumption while taking Valproic Acid. Alcohol can potentially increase the risk of liver problems and can also add to the drowsiness caused by this medication.
Can Valproic Acid affect my weight?
Yes, some people experience weight gain while taking Valproic Acid. It s important to maintain a balanced diet and regular exercise.
What if I have forgotten to take a dose of Valproic Acid?
In case you miss a dose, take it as soon as you remember. If it's nearly time for your next dose, skip the missed dose. Remember, don't double your doses to make up for a missed one.
Does valproate affect fertility?
Yes, valproate can affect fertility in women and men, although this is usually reversible once the medication is stopped.
Can I stop taking Valproic Acid once my symptoms improve?
No, stopping Valproic Acid abruptly may lead to withdrawal symptoms or condition relapse. Consult your doctor about stopping or changing the dose of the medication.
Can valproate cause hair loss?
Yes, some people have reported hair loss while taking valproate. However, this is often temporary and will reverse once the medication is stopped.
Comprehensive Drug Guide
How Does Valproic Acid Work?
Valproic Acid is an anticonvulsant drug that modulates the level of GABA (an inhibitory neurotransmitter) in our brain, this helps in controlling seizures and managing mood disorders.
What is Valproic Acid Used For?
FDA indications: Valproic Acid is primarily used to treat seizures and bipolar disorder. It's also used as a preventive measure for migraine headaches.
Off-label uses: Valproic Acid can be used to manage aggressive behavior or agitation in people with dementia.
Common Dosages
Tablets: 250mg, 500mg
Liquid: 250mg/5ml
Injectable: 100mg/ml
Typical Dosing
FDA Approved Indications
- For seizures: The starting dose is usually around 15mg/kg/day, increasing gradually until seizures are controlled.
- For bipolar disorder: The typical adult dose starts at 750mg/day and is increased as necessary.
- For migraines: The usual amount is 250mg twice daily as a preventive measure.
- Pediatric Dosing
- For seizures: The recommended initial dose is 10 to 15mg/kg/day, gradually increasing by 5 to 10mg/kg/day every week, as needed to control the seizures.
- Always remember to follow the doctor's instructions carefully when it comes to pediatric dosing. Regular checkups are also important, especially as Valproic Acid can affect liver function.
- Handle with care if the child has liver problems.
Who Shouldn't Take Valproic Acid?
- Those with liver problems.
- Pregnant women or women planning to become pregnant due to the potential risk to the fetus.
- Breastfeeding mothers ? Valproic acid passes into breast milk, and it could affect a nursing infant.
- Patients with a genetic condition known as urea cycle disorders.
- Individuals with a history of hypersensitivity or allergic reactions to Valproate products.
Advice From The Pharmacist
- - Take this medication with food if it causes stomach upset.
- - You might need to get blood tests done while you're on this medication. This is to keep an eye on how this medication is affecting your body.
- - This medication can cause drowsiness. Use caution if you have to do something that requires focus, like driving or operating machinery.
- - Limit your alcohol intake while on this medication. Alcohol can interfere with the way this medication works and can increase your risk of side effects.
- - Pregnancy must be avoided while on this medication due to the risk of birth defects.
Side Effects of Valproic Acid
Common Side Effects
- - Common side effects: Nausea, vomiting, stomach pain, dizziness, sleepiness, or tremors
Uncommon/Severe Side Effects
- - Rare, but serious side effects: Easy bruising, unusual bleeding (nosebleeds, bleeding gums), signs of liver problems (dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin), loss of seizure control, suicidal thoughts, signs of pancreatitis (stomach/abdominal/back pain, fever, fast heartbeat, swollen abdomen).
Risks and Warnings of Valproic Acid
- Valproic Acid should not be used in individuals with liver disease, urea cycle disorders, or significant past hypersensitivity reactions to the drug.
- If you have pancreatitis or a history of it, be cautious with Valproic Acid.
- Alcohol use should be limited as it can increase the risk of liver damage.
- Pregnancy should be avoided due to the risk of birth defects in the baby.
Interactions with Valproic Acid
Common Drug Interactions
- Other seizure medications
- Certain antibiotics or antiviral medications
- Blood thinners
- Sleeping pills or anxiety medications
Alternatives to Valproic Acid
- Lithium
- Lamotrigine
- Lorazepam
- Phenobarbital
- Carbamazepine
