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Onfi
Onfi (clobazam) is a benzodiazepine medication primarily used as an adjunctive treatment for Lennox-Gastaut syndrome, a severe form of epilepsy. It is indicated for use in conjunction with other antiepileptic drugs to help reduce seizure frequency.
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Frequently Asked Questions
How quickly does Onfi work?
Patients may begin to notice a reduction in seizure frequency within the first few weeks of treatment, but optimal effects may take longer.
Can I take Onfi with food?
Yes, Onfi can be taken with or without food. Consistency in how you take it is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Onfi safe during pregnancy?
Onfi should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for signs of severe allergic reactions or respiratory issues, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Onfi Work?
Onfi works by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This action increases inhibitory neurotransmission in the brain, resulting in sedation, anxiolytic effects, and reduced seizure activity.
Common Dosages
- Tablets: Common strengths include 5 mg, 10 mg, and 20 mg.
- Oral suspension: Concentration of 2.5 mg/mL.
Typical Dosing
- Adults and Children (2 years and older): The usual recommended starting dose is 5 mg taken once daily, which may be gradually increased based on clinical response. The maximum recommended dose is 40 mg per day.
Typical Dosing
FDA Approved Indications
- Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients aged 2 years and older.
Who Shouldn't Take Onfi?
- Known hypersensitivity to clobazam or any component of the formulation.
- Acute narrow-angle glaucoma.
Advice From The Pharmacist
- Take Onfi exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- Be cautious when driving or operating heavy machinery until you know how Onfi affects you, as it may cause sedation.
- Monitor for any changes in mood, behavior, or suicidal thoughts, especially when starting treatment or adjusting the dose.
Side Effects of Onfi
Common Side Effects
- Drowsiness
- Fatigue
- Ataxia (lack of muscle coordination)
- Salivation
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Respiratory depression
Risks and Warnings of Onfi
- Dependence and Withdrawal: Long-term use of benzodiazepines can lead to dependence; tapering may be necessary to avoid withdrawal symptoms.
- Respiratory Effects: Use with caution in patients with respiratory issues, as it can depress respiration.
Interactions with Onfi
Common Drug Interactions
- CNS Depressants: Use caution when combining with other medications that cause sedation, such as opioids, alcohol, or other benzodiazepines.
- Antiepileptic Drugs: Monitor closely when used in combination with other antiepileptic medications.
Alternatives to Onfi
- Other Antiepileptics: Such as lamotrigine or levetiracetam for similar indications.
- Other Benzodiazepines: Such as clonazepam for seizure management in some cases.
