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lamoTRIgine

Lamotrigine is a type of medication known as an anticonvulsant or antiepileptic drug. It's used for conditions like epilepsy and bipolar disorder, as it can help control seizures and mood episodes. Some common side effects include dizziness, headache, blurred or double vision, and mild rash.

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Frequently Asked Questions

Does lamotrigine make you lose weight?
Open FAQClose FAQ

Weight loss is not a common side effect of lamotrigine, but it can happen. If you're unexpectedly losing weight while taking this drug, check with your doctor.

I missed a dose of lamotrigine, what should I do?
Open FAQClose FAQ

If it’s close to the time for your next dose, skip the missed one. Otherwise, take it as soon as you remember. Make sure there's at least half the time to your next dose remaining. Never double doses.

Can I suddenly stop taking lamotrigine?
Open FAQClose FAQ

No, don't stop taking lamotrigine without talking to your doctor, even if you feel better. Stopping the drug suddenly can increase your risk of seizures.

Will lamotrigine interact with my other medications?
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Possibly. That’s why your doctor needs to know about all the medications you’re taking. Lamotrigine can interact with many medications, including other anticonvulsants, some antibiotics, and hormonal contraceptives.

Can I drink alcohol while taking lamotrigine?
Open FAQClose FAQ

It's better to avoid alcohol while taking lamotrigine. Alcohol can increase the side effects of the drug and can also increase your risk of seizures.

Comprehensive Drug Guide

How Does lamoTRIgine Work?

Lamotrigine is thought to inhibit the release of glutamate via the inhibition of voltage-sensitive sodium channels.

What is lamoTRIgine Used For?

Bipolar 1 disorder, Lennox-Gataut syndrome, Seizure

Common Dosages

  • Tablets: 25mg, 50mg, 100mg, 200mg
  • Chewable Tablets: 5mg, 25mg.
  • Oral Disintegrating Tablets: 25mg, 50mg, 100mg, 200mg.
  • Extended-Release Tablets: 25mg, 50mg, 100mg, 200mg, 250mg, 300mg.

Typical Dosing

FDA Approved Indications

  • Epilepsy: Starting at 25mg daily for 2 weeks, followed by 50mg daily for 2 weeks. The dosage may then be increased weekly by 100mg.
  • Bipolar Disorder: Starting at 25mg daily for 2 weeks, followed by an increase to 50mg daily for another 2 weeks before the dosage may be increased further. 

Off-Label Uses

Bipolar Disorder, Depression, Neuropathy due to diabetes mellitus, obsessive-compulsive disorder

Who Shouldn't Take lamoTRIgine ?

  • Anybody with a history of allergy or rash to lamotrigine or any other medicine in this class.

Advice From The Pharmacist

  • It can be taken with or without food.
  • Don't crush, chew, or break an extended-release tablet, swallow it whole.
  • Try to take the medication at the same time each day.
  • Don't stop using lamotrigine without your doctor's advice, even if you feel fine.
  • Tell your doctor if you become pregnant while taking this medicine. Do not start or stop taking seizure medication during pregnancy without your doctor's advice.
  • Call your doctor right away if you have any mood or behavior changes, depression, anxiety, suicidal thoughts, or feelings about self-harm.
  • Consider wearing a medical alert tag stating that you're taking lamotrigine, in case of emergency.
  • Drink plenty of liquids while you are taking this medication to lower your risk of developing kidney stones.

Side Effects of lamoTRIgine

Common Side Effects

  • Dizziness
  • Insomnia, fatigue
  • Blurred or double vision
  • Tired feeling, dizziness, loss of coordination
  • Dry mouth, mild diarrhea
  • Back pain, joint or muscle pain

Uncommon/Severe Side Effects

  • Anemia
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis

Risks and Warnings of lamoTRIgine

  • If you observe any early signs of serious skin reactions such as fever, swollen lymph nodes, or rash, consult your doctor immediately. 
  • Inform your doctor if you're taking hormonal birth control, as it might impact the effectiveness of Lamotrigine.

Interactions with lamoTRIgine

Common Drug Interactions

  • Antivirals
  • Contraceptives
  • Other anticonvulsant medications (e.g., phenytoin, carbamazepine)
  • Certain antibiotics, notably rifampin

Alternatives to lamoTRIgine

  • Valproic acid
  • Lithium
  • Topiramate