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Super Tri-Mix
Super Tri-Mix is a compounded injectable medication used to treat erectile dysfunction (ED). It typically contains a combination of papaverine, phentolamine, and alprostadil. These three medications work together to promote blood flow to the penis, helping men achieve and maintain an erection. Super Tri-Mix is commonly prescribed when oral medications, such as PDE5 inhibitors (e.g., sildenafil or tadalafil), are ineffective or not suitable for the patient.
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Frequently Asked Questions
How long does it take for Super Tri-Mix to work?
Super Tri-Mix usually starts working within **5 to
Can I adjust my dose of Super Tri-Mix on my own?
No, you should never adjust your dose without consulting your healthcare provider. Your doctor will determine the correct dose based on your response and tolerance.
How often can I use Super Tri-Mix?
Super Tri-Mix should not be used more than once in a 24-hour period or more than 3 times a week. Overuse can increase the risk of side effects such as priapism or tissue damage.
What should I do if I experience an erection lasting more than 4 hours?
This is a medical emergency called priapism. You should seek immediate medical attention to prevent long-term damage to the penis.
Can I store Super Tri-Mix at room temperature?
No, Super Tri-Mix should be stored in the refrigerator to maintain its effectiveness. It should not be frozen, and you should allow the medication to warm to room temperature before injecting.
Comprehensive Drug Guide
How Does Super Tri-Mix Work?
- Papaverine is a vasodilator that relaxes blood vessels, allowing increased blood flow.
- Phentolamine blocks alpha-adrenergic receptors, which helps prevent the constriction of blood vessels.
- Alprostadil is a prostaglandin that promotes the dilation of blood vessels and improves blood flow to the penis.
Common Dosages
- Papaverine: 30 mg/ml to 150 mg/ml
- Phentolamine: 0.5 mg/ml to 5 mg/ml
- Alprostadil: 10 mcg/ml to 20 mcg/ml
Typical Dosing
- The dose is usually administered as a self-injection into the base or side of the penis, approximately 5 to 15 minutes before sexual activity.
- The dose and injection frequency are determined by the prescribing doctor, and adjustments may be made based on efficacy and tolerance.
Typical Dosing
FDA Approved Indications
- The treatment of erectile dysfunction (ED) in adult men. It is often prescribed for men who do not respond well to oral ED medications or for those with underlying conditions that make oral treatments unsuitable.
Who Shouldn't Take Super Tri-Mix?
- Known hypersensitivity to any of the components of the mixture
- Conditions that predispose to priapism (prolonged erections), such as sickle cell anemia or multiple myeloma
- Penile anatomical abnormalities, such as Peyronie’s disease
- Active penile infections
Advice From The Pharmacist
- Ensure you understand the proper injection technique before using Super Tri-Mix at home. Incorrect injection may result in pain or damage.
- Rotate injection sites to avoid tissue damage or scarring.
- Never inject more than the prescribed amount. If an erection lasts longer than 4 hours (a condition called priapism), seek immediate medical attention.
- Store Super Tri-Mix in the refrigerator, and do not freeze it. Allow the medication to warm to room temperature before injecting.
- Dispose of used needles and syringes properly.
Side Effects of Super Tri-Mix
Common Side Effects
- Mild pain or bruising at the injection site
- Prolonged erections (priapism)
- Dizziness or lightheadedness
- Redness or swelling at the injection site
Uncommon/Severe Side Effects
- Priapism (erections lasting longer than 4 hours), which requires immediate medical intervention
- Penile fibrosis (scar tissue formation)
- Infection at the injection site
Risks and Warnings of Super Tri-Mix
- Priapism Risk: Super Tri-Mix can cause prolonged erections, which can lead to permanent damage if left untreated. Seek immediate medical help if an erection lasts longer than 4 hours.
- Injection Site Reactions: Regularly rotating injection sites is crucial to prevent scarring or tissue damage.
- Cardiovascular Risk: Patients with underlying cardiovascular issues should use Super Tri-Mix cautiously, as it may cause changes in blood pressure.
Interactions with Super Tri-Mix
Common Drug Interactions
- Blood pressure medications: Super Tri-Mix can interact with antihypertensive drugs, leading to a further decrease in blood pressure.
- Anticoagulants: Use caution when taking blood thinners, as Super Tri-Mix may increase the risk of bleeding or bruising at the injection site.
Alternatives to Super Tri-Mix
- Caverject (alprostadil): A single-agent prostaglandin injection used for erectile dysfunction.
- Edex (alprostadil): Another alprostadil-based injection used to treat erectile dysfunction.
- Trimix: A similar compounded medication but typically with slightly different strengths or components.
- Oral PDE5 inhibitors: Such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra), which may be alternatives if suitable for the patient.
