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Indomethacin
Indomethacin is a type of medication classified as a nonsteroidal antiinflammatory drug (NSAID). It's used to relieve pain, swelling, and joint stiffness caused by conditions like arthritis, bursitis, and gout attacks. Some common side effects include headaches, dizziness, and upset stomach. But fear not, your doctor is here to make sure the benefits outweigh these cons.
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Frequently Asked Questions
Can I take Indomethacin if I have ulcers/stomach problems?
NSAIDs like Indomethacin can irritate the stomach lining and worsen ulcers. Always consult a doctor.
Does Indomethacin make me sensitive to sunlight?
Yeah, it's a possibility. Some folks may find their skin more sensitive to sunlight. Applying a high SPF sunblock and wearing protective clothing can help.
I missed a dose of Indomethacin, what should I do?
No biggie! If it's close to the time for your next dose, skip the missed one. If not, take it as soon as you remember. But don't double up doses.
Comprehensive Drug Guide
How Does Indomethacin Work?
Indomethacin stops the body's production of a substance that causes pain, fever, and inflammation, reducing these symptoms.
What is Indomethacin Used For?
FDA indications: Indomethacin treats moderate to severe arthritis, ankylosing spondylitis, and gouty arthritis. It's also prescribed for shoulder pain from bursitis or tendinitis.
Offlabel uses: It's been used to close a patent ductus arteriosus in premature infants.
Common Dosages
Capsules: 25mg, 50mg
Extendedrelease capsules: 75mg
Oral Suspension: 25mg/5mL
Typical Dosing
FDA Approved Indications
- Arthritis, Ankylosing spondylitis, Bursitis, Tendinitis: 2550mg 23 times a day.
Off-Label Uses
- Acute Gouty Arthritis: 50mg 3 times a day.
Who Shouldn't Take Indomethacin?
- Have an allergy to aspirin or other NSAIDs.
- Have a history of asthma, urticaria (hives), or allergic reactions after taking aspirin or other NSAIDs.
- Have a history of bleeding problems or stomach bleeding after taking NSAIDs.
- I just had a heart bypass surgery or about to have one.
- Are in the third trimester of pregnancy or breastfeeding (it can harm the baby).
- Have kidney, liver, or heart diseases.
Advice From The Pharmacist
- Don't lie down for at least 10 minutes after taking this drug.
- Avoid sun exposure. Indomethacin can make your skin sensitive to sunlight.
- Drink plenty of fluids to avoid dehydration.
- Try to eat healthy. Indomethacin can cause stomach bleeding.
- Avoid alcohol. It may increase your risk of stomach bleeding.
- Maintain your dental health. Brush and floss your teeth regularly as indomethacin may cause mouth sores.
Side Effects of Indomethacin
Common Side Effects
- Common Side Effects:
- Upset stomach, heartburn.
- Dizziness, drowsiness.
- Headache.
Uncommon/Severe Side Effects
- Uncommon/Rare Side Effects:
- Easy bleeding/bruising.
- Swelling of hands, ankles, or feet (fluid retention).
- Rapid weight gain.
- Serious Side Effects:
- Chest/jaw/left arm pain.
- Weakness on one side of the body, slurred speech, sudden vision changes.
Risks and Warnings of Indomethacin
- Can cause stomach bleeding and kidney problems. Avoid use if you have a history of these conditions.
- Can raise blood pressure, hence should be used cautiously by hypertensive individuals.
- Pregnancy and breastfeeding also add a layer of caution. The impacts on the infant aren't known.
- People with mood disorders should tread carefully. Indomethacin may potentially trigger or worsen these conditions.
Interactions with Indomethacin
Common Drug Interactions
- Anticoagulants (like warfarin)
- Antiplatelets (like clopidogrel)
- Selective serotonin reuptake inhibitors (like fluoxetine)
- Angiotensinconverting enzyme (ACE) inhibitors (like lisinopril)
- Loop diuretics (like furosemide)
- Lithium
- Methotrexate
- Cyclosporine
- Other NSAIDs (like ibuprofen, naproxen)
Alternatives to Indomethacin
- Naproxen
- Ibuprofen
- Aspirin
- Ketorolac
- Meloxicam
- Piroxicam
