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Generic Symbyax
Symbyax combines olanzapine, an antipsychotic, and fluoxetine, an antidepressant, to treat depression in bipolar disorder and treatment-resistant depression. It helps balance mood and improve symptoms of both conditions.
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Frequently Asked Questions
What is generic Symbyax (Olanzapine-Fluoxetine HCl) used for?
Generic Symbyax is used to treat depression associated with bipolar I disorder and treatment-resistant depression.
How long does it take for generic Symbyax to work?
It may take several weeks to feel the full effects of Symbyax. Some symptoms may improve within 1-2 weeks, but mood changes may take longer.
Can I drink alcohol while taking generic Symbyax?
It’s recommended to avoid alcohol while taking Symbyax, as it can increase drowsiness and other side effects.
What should I do if I miss a dose of generic Symbyax?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double up to make up for the missed dose.
What are the potential side effects of generic Symbyax?
Common side effects include drowsiness, weight gain, and dry mouth. Severe side effects may include mood changes, suicidal thoughts, and increased blood sugar levels. Contact your doctor if you experience severe symptoms.
Comprehensive Drug Guide
How Does Generic Symbyax Work?
Symbyax is a combination of two medications, olanzapine and fluoxetine, that work together to treat depression and bipolar disorder. Olanzapine is an antipsychotic that helps balance chemicals in the brain related to mood and behavior, reducing symptoms like mania or psychosis. Fluoxetine is an antidepressant that increases serotonin levels in the brain, which improves mood and helps relieve depression. Together, these medications target both the depressive and manic aspects of bipolar disorder, providing more comprehensive treatment for mood stabilization and improved mental health.
What is Generic Symbyax Used For?
Symbyax is used to treat depression in people with bipolar disorder and for treating depression that hasn’t responded to other medications. It helps manage both depressive and manic symptoms, stabilizing mood and improving mental health in those with these conditions.
Common Dosages
Olanzapine-Fluoxetine-HCL (Generic Symbyax) is commonly manufactured in the following formulations:
Capsules:
- 3 mg Olanzapine / 25 mg Fluoxetine
- 6 mg Olanzapine / 25 mg Fluoxetine
- 6 mg Olanzapine / 50 mg Fluoxetine
- 12 mg Olanzapine / 25 mg Fluoxetine
- 12 mg Olanzapine / 50 mg Fluoxetine
Typical Dosing
FDA Approved Indications
Generic Symbyax is approved by the FDA to treat the following:
- Treatment of depression associated with bipolar I disorder.
- Treatment of treatment-resistant depression (major depressive disorder that hasn't responded to other antidepressants).
Off-Label Uses
Off-label uses for generic Symbyax include:
- Anxiety disorders
- Obsessive-compulsive disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Borderline personality disorder (BPD)
- Schizophrenia (in some cases, particularly with co-occurring depression)
Pediatric Dosing
For pediatric patients aged 10 to 17 years with bipolar depression or treatment-resistant depression, the starting dose is typically:
3 mg Olanzapine / 25 mg Fluoxetine once daily
The dose may be adjusted based on the patient’s response and tolerance. The maximum dose for pediatric patients generally does not exceed 12 mg Olanzapine / 50 mg Fluoxetine daily.
However, due to potential side effects and risks, including weight gain, metabolic changes, and other serious effects, Symbyax should be used cautiously in pediatric populations and under close supervision by a healthcare provider.
Who Shouldn't Take Generic Symbyax?
- Use with MAOIs or within 14 days of stopping an MAOI.
- Concurrent use with pimozide or thioridazine.
- Known hypersensitivity to olanzapine, fluoxetine, or any ingredients in Symbyax.
Advice From The Pharmacist
Take with or without food: Symbyax can be taken with or without meals, but for consistency, try to take it at the same time each day.
Avoid alcohol: Drinking alcohol while on Symbyax can increase drowsiness and other side effects.
Monitor mood changes: Watch for sudden mood shifts, worsening depression, or suicidal thoughts, especially when starting or adjusting the dose. Notify your doctor immediately if these occur.
Stay hydrated: Symbyax can cause dry mouth, so drink plenty of water.
Be aware of drowsiness: This medication can cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
Don't stop suddenly: Stopping Symbyax abruptly can cause withdrawal symptoms. Always taper off under your doctor’s supervision.
Check blood sugar: For diabetic patients, Symbyax can raise blood sugar levels. Monitor your glucose regularly.
Side Effects of Generic Symbyax
Common Side Effects
- Drowsiness or fatigue
- Weight gain
- Increased appetite
- Dry mouth
- Dizziness
- Constipation
Uncommon/Severe Side Effects
- Suicidal thoughts or behaviors
- Severe mood changes (e.g., mania)
- High blood sugar or diabetes symptoms
- Seizures
- Serious allergic reactions (e.g., rash, swelling)
- Neuroleptic malignant syndrome (rare, life-threatening reaction)
- Tardive dyskinesia (involuntary movements)
Risks and Warnings of Generic Symbyax
Suicidal thoughts: Increased risk, especially in young adults and children.
Metabolic changes: Can cause weight gain, high blood sugar, and cholesterol changes.
Neuroleptic Malignant Syndrome (NMS): Rare, life-threatening reaction causing muscle rigidity and fever.
Tardive Dyskinesia: Risk of irreversible involuntary movements with long-term use.
Low blood pressure: May cause dizziness or fainting, especially when standing up.
Seizures: Increased risk, especially in patients with a history of seizures.
Serotonin syndrome: Risk when combined with other serotonergic drugs.
Alternatives to Generic Symbyax
Lithium + Fluoxetine: A combination used for bipolar depression.
Quetiapine (Seroquel): An antipsychotic for bipolar disorder and depression.
Lamotrigine (Lamictal): A mood stabilizer for bipolar depression.
Venlafaxine (Effexor XR): An antidepressant that can be used for treatment-resistant depression.
Aripiprazole (Abilify) + Antidepressant: A combination for bipolar depression and major depressive disorder.
