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Fenofibrate Micronized
Fenofibrate Micronized is a lipid-lowering medication used to reduce cholesterol and triglycerides in the blood. It is typically prescribed for individuals with hypercholesterolemia (high cholesterol) or hypertriglyceridemia (high triglycerides) to help reduce the risk of atherosclerosis (hardening of the arteries), heart attack, stroke, and other cardiovascular events. The micronized formulation of fenofibrate is designed for better absorption, meaning it is more easily absorbed into the bloodstream, which may allow for more consistent effects at lower doses.
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Frequently Asked Questions
How long does it take for Fenofibrate Micronized to work?
Fenofibrate Micronized typically takes several weeks to lower cholesterol and triglyceride levels. Regular blood tests will help monitor your progress, usually after 4 to 8 weeks of treatment.
Can I take Fenofibrate Micronized with other cholesterol-lowering medications?
Yes, fenofibrate is sometimes prescribed in combination with statins, but it is important to monitor for signs of muscle pain or weakness, as the combination can increase the risk of muscle damage.
What should I do if I miss a dose of Fenofibrate?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Can Fenofibrate Micronized cause liver problems?
Yes, fenofibrate can cause liver toxicity in some patients. It’s important to have regular liver function tests and report any signs of liver issues, such as yellowing of the skin or eyes, to your healthcare provider.
Should I avoid certain foods while taking Fenofibrate?
While there are no specific food restrictions, it’s important to follow a low-fat, low-cholesterol diet to maximize the effectiveness of the medication. Avoid excessive alcohol consumption, as it can increase the risk of liver damage.
Comprehensive Drug Guide
How Does Fenofibrate Micronized Work?
Fenofibrate works by activating peroxisome proliferator-activated receptor alpha (PPAR-α), a receptor involved in lipid metabolism. Activation of PPAR-α increases the breakdown and removal of triglycerides from the blood and promotes the production of high-density lipoprotein (HDL), or "good cholesterol." It also reduces the production of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), commonly referred to as "bad cholesterol." This combined effect helps to reduce overall cholesterol and triglyceride levels.
Common Dosages
- For primary hypercholesterolemia or mixed dyslipidemia: The usual dose is 130 mg once daily.
- For severe hypertriglyceridemia: The starting dose is usually 43 mg to 200 mg once daily, depending on the patient’s response.
Typical Dosing
FDA Approved Indications
- Primary hypercholesterolemia or mixed dyslipidemia: To reduce elevated LDL cholesterol, total cholesterol, triglycerides, and apolipoprotein B.
- Severe hypertriglyceridemia: To reduce very high triglyceride levels and the risk of pancreatitis.
Who Shouldn't Take Fenofibrate Micronized?
- Known hypersensitivity to fenofibrate or any components of the formulation.
- Severe liver disease or primary biliary cirrhosis.
- Severe kidney disease or patients on dialysis.
- Gallbladder disease.
- Nursing mothers.
Advice From The Pharmacist
- Take fenofibrate with food, as it improves absorption and effectiveness. The micronized formulation is designed for better absorption, but it still benefits from being taken with a meal.
- Regular blood tests will be needed to monitor liver function and lipid levels. Report any signs of liver issues, such as jaundice (yellowing of the skin or eyes) or dark urine, to your healthcare provider immediately.
- Avoid drinking alcohol while taking fenofibrate, as it can increase the risk of liver damage.
- Continue following a cholesterol-lowering diet and maintain a healthy lifestyle, as fenofibrate works best when combined with diet and exercise.
Side Effects of Fenofibrate Micronized
Common Side Effects
- Stomach pain
- Nausea or vomiting
- Diarrhea
- Headache
- Elevated liver enzymes (found during routine blood tests)
Uncommon/Severe Side Effects
- Liver toxicity (jaundice, dark urine, fatigue)
- Muscle pain or weakness (myopathy), which could lead to a serious condition called rhabdomyolysis.
- Pancreatitis (severe abdominal pain, nausea, vomiting)
- Gallstones
Risks and Warnings of Fenofibrate Micronized
- Liver Toxicity: Fenofibrate has been associated with liver damage in some patients. Routine liver function tests are necessary during treatment, especially during the first few months.
- Myopathy and Rhabdomyolysis: The risk of muscle damage increases when fenofibrate is taken in combination with statins. Patients should report any unexplained muscle pain, tenderness, or weakness to their healthcare provider immediately.
- Gallstones: Fenofibrate can increase the risk of developing gallstones. Patients with a history of gallbladder disease should avoid this medication.
Interactions with Fenofibrate Micronized
Common Drug Interactions
- Statins (e.g., atorvastatin, simvastatin): Combining fenofibrate with statins increases the risk of muscle damage (myopathy or rhabdomyolysis).
- Blood thinners (e.g., warfarin): Fenofibrate may increase the effects of blood thinners, raising the risk of bleeding. Regular monitoring of INR (a blood clotting test) is required.
- Immunosuppressants (e.g., cyclosporine): Fenofibrate may affect kidney function when taken with immunosuppressants.
Alternatives to Fenofibrate Micronized
- Gemfibrozil (Lopid): Another fibrate used to lower triglyceride levels, although it may have a higher risk of drug interactions than fenofibrate.
- Atorvastatin (Lipitor): A statin medication used to lower cholesterol and reduce cardiovascular risk.
- Ezetimibe (Zetia): A cholesterol absorption inhibitor used in combination with statins or alone to lower LDL cholesterol.
- Omega-3 fatty acid supplements (e.g., Lovaza): Used to lower triglycerides in patients with very high triglyceride levels.
