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Eletriptan Hydrobromide
Eletriptan Hydrobromide is a medication used to treat acute migraine attacks with or without aura in adults. It belongs to a class of drugs called triptans, which are selective serotonin (5-HT) receptor agonists. Eletriptan works by narrowing the blood vessels around the brain and reducing substances in the body that can trigger headache pain, nausea, and sensitivity to light and sound. It is not used to prevent migraines, only to treat them once they have started.
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Frequently Asked Questions
How long does it take for Eletriptan to work?
Eletriptan typically begins to work within 30 minutes to 2 hours after taking the tablet. Most patients experience relief within this time frame.
Can I take Eletriptan if I have high blood pressure?
Eletriptan should not be used by individuals with uncontrolled high blood pressure, as it can increase blood pressure. If you have controlled hypertension, discuss your treatment options with your healthcare provider.
Can Eletriptan prevent migraines?
No, Eletriptan is only used to treat migraines once they have started. It is not intended for migraine prevention. Preventive medications, such as beta-blockers or anticonvulsants, may be prescribed for those with frequent migraines.
Can I take Eletriptan with over-the-counter pain relievers?
Eletriptan can be taken with over-the-counter medications like acetaminophen or ibuprofen for additional pain relief. However, avoid using other migraine-specific medications, such as triptans or ergotamines, within 24 hours of taking Eletriptan.
What should I do if Eletriptan doesn’t relieve my migraine?
If Eletriptan does not work for your migraine or if the pain returns within 24 hours, consult your healthcare provider for alternative treatment options or dosage adjustments.
Comprehensive Drug Guide
How Does Eletriptan Hydrobromide Work?
Eletriptan binds to serotonin (5-HT1B and 5-HT1D) receptors on blood vessels and nerve endings in the brain. This action causes the blood vessels to constrict (narrow), reducing the inflammation that contributes to migraine pain. Additionally, it inhibits the release of neuropeptides that trigger pain and other migraine symptoms, providing relief from the migraine attack.
What is Eletriptan Hydrobromide Used For?
Common Dosages
Eletriptan Hydrobromide is available in the following strengths:
- 20 mg tablets
- 40 mg tablets
Typical Dosing
- For acute migraine treatment, the usual starting dose is 40 mg taken orally as soon as migraine symptoms appear.
- If the migraine is not relieved, a second dose may be taken after 2 hours, but no more than 80 mg should be taken within 24 hours.
- If the lower dose (20 mg) is prescribed, follow the same guidelines.
Typical Dosing
FDA Approved Indications
- Acute treatment of migraine attacks with or without aura in adults
Who Shouldn't Take Eletriptan Hydrobromide?
- Known hypersensitivity to eletriptan or any component of the formulation
- History of stroke or transient ischemic attack (TIA)
- History of ischemic heart disease, coronary artery disease, or angina
- Severe hepatic impairment
- Uncontrolled hypertension
Advice From The Pharmacist
- Take Eletriptan Hydrobromide as soon as you notice migraine symptoms. It is most effective when taken early in the attack.
- Do not take more than 80 mg of eletriptan in a 24-hour period.
- If your first dose does not provide relief, consult your doctor rather than continuing to take additional doses.
- Avoid driving or operating machinery until you know how the medication affects you, as it may cause dizziness or drowsiness.
Side Effects of Eletriptan Hydrobromide
Common Side Effects
- Dizziness
- Fatigue
- Nausea
- Dry mouth
- Weakness
Uncommon/Severe Side Effects
- Heart attack or stroke symptoms (chest pain, shortness of breath, sudden numbness or weakness)
- Severe hypertension
- Serotonin syndrome (especially if taken with other serotonergic medications)
Risks and Warnings of Eletriptan Hydrobromide
- Cardiovascular Risk: Eletriptan can cause coronary artery vasospasm and other serious cardiovascular events, including heart attack and stroke. It should not be used by individuals with a history of heart disease, stroke, or uncontrolled high blood pressure.
- Medication Overuse Headache: Using eletriptan too frequently can result in medication overuse headaches (rebound headaches). Limit its use to no more than 10 days per month.
- Serotonin Syndrome: The risk of serotonin syndrome increases when eletriptan is taken with other serotonergic drugs, such as antidepressants (SSRIs, SNRIs).
Interactions with Eletriptan Hydrobromide
Common Drug Interactions
- SSRIs and SNRIs: Taking eletriptan with these types of antidepressants can increase the risk of serotonin syndrome, a potentially life-threatening condition.
- Other Triptans or Ergotamines: Avoid using eletriptan within 24 hours of taking another triptan or ergotamine-based medication to prevent vasoconstrictive side effects.
- CYP3A4 Inhibitors: Medications that inhibit the enzyme CYP3A4 (e.g., ketoconazole, clarithromycin) may increase blood levels of eletriptan, increasing the risk of side effects. Dosage adjustments may be necessary.
Alternatives to Eletriptan Hydrobromide
- Sumatriptan (Imitrex): Another triptan used to treat migraines, available in oral, nasal spray, and injectable forms.
- Rizatriptan (Maxalt): A triptan with a slightly faster onset of action, also available as orally disintegrating tablets.
- Zolmitriptan (Zomig): A triptan available in oral and nasal spray forms, used for the acute treatment of migraines.
- Naratriptan (Amerge): A slower-acting but longer-lasting triptan used to treat migraines.
