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Azopt
Azopt (brinzolamide) is a carbonic anhydrase inhibitor used as an ophthalmic solution to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. By lowering IOP, Azopt helps prevent damage to the optic nerve, which can lead to vision loss or blindness. It is commonly prescribed when patients do not respond well to other IOP-lowering treatments.
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Frequently Asked Questions
How quickly does Azopt start working?
Azopt begins to lower intraocular pressure within a few hours of application, but full effects may take several days of consistent use.
Can I use Azopt with other eye drops?
Yes, but it’s important to wait at least 10 minutes between applying Azopt and any other eye medications to prevent dilution and ensure proper absorption.
Can I wear contact lenses while using Azopt?
You should remove your contact lenses before applying Azopt, as the preservative in the medication can be absorbed by soft lenses. Wait at least 15 minutes before reinserting them.
What should I do if I miss a dose of Azopt?
If you miss a dose, apply it as soon as you remember. If it is close to the time of your next scheduled dose, skip the missed dose and resume your normal dosing schedule. Do not double doses.
Is Azopt safe for long-term use?
Yes, Azopt is generally safe for long-term use when prescribed by a healthcare provider, but regular monitoring of intraocular pressure is essential to ensure the medication is effective.
Comprehensive Drug Guide
How Does Azopt Work?
Azopt works by inhibiting the enzyme carbonic anhydrase in the ciliary body of the eye, which decreases the production of aqueous humor (fluid in the eye). This reduction in fluid production leads to a decrease in intraocular pressure, which is crucial for preventing optic nerve damage and vision loss in glaucoma patients.
Common Dosages
- Ophthalmic suspension: 1% brinzolamide
Typical Dosing
- For open-angle glaucoma or ocular hypertension: The usual dosage is one drop of Azopt in the affected eye(s) two to three times daily. Shake the bottle well before each use.
Typical Dosing
FDA Approved Indications
- Elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Who Shouldn't Take Azopt?
- Known hypersensitivity to brinzolamide or other sulfonamides, as it may cause allergic reactions.
- Severe kidney impairment, as Azopt is primarily eliminated by the kidneys.
- Caution in patients with hepatic impairment.
Advice From The Pharmacist
- Shake the bottle well before applying the eye drops to ensure the medication is properly mixed.
- If you are using other eye drops, wait at least 10 minutes between administering Azopt and any other eye medications.
- Do not let the dropper tip touch your eye or any other surfaces to avoid contamination.
- If you wear contact lenses, remove them before using Azopt and wait at least 15 minutes before reinserting them, as the preservative in Azopt can be absorbed by soft lenses.
Side Effects of Azopt
Common Side Effects
- Blurred vision
- Bitter or unusual taste in the mouth
- Eye discomfort or irritation
- Dry eyes
Uncommon/Severe Side Effects
- Severe allergic reactions, such as rash, swelling, or difficulty breathing.
- Severe eye pain or vision changes.
Risks and Warnings of Azopt
- Sulfa Allergy: Azopt is chemically related to sulfonamides, so it should be avoided in patients with a history of sulfa allergies, as it can trigger similar allergic reactions.
- Systemic Absorption: Though used as an eye drop, small amounts of Azopt can be absorbed into the bloodstream, leading to side effects like fatigue or changes in taste.
- Kidney and Liver Disease: Azopt should be used with caution in patients with kidney or liver impairment, as it can accumulate in the body and cause toxicity.
Interactions with Azopt
Common Drug Interactions
- Other Carbonic Anhydrase Inhibitors: Using Azopt with oral carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of side effects.
- High-dose Aspirin: Caution should be used when taking Azopt alongside high-dose aspirin, as both can have effects on acid-base balance in the body.
- Other Eye Medications: To avoid interactions, ensure you wait at least 10 minutes between applying different eye drops.
Alternatives to Azopt
- Trusopt (dorzolamide): Another carbonic anhydrase inhibitor used to lower intraocular pressure.
- Timoptic (timolol): A beta-blocker eye drop commonly used to lower IOP in glaucoma patients.
- Xalatan (latanoprost): A prostaglandin analog used to reduce intraocular pressure.
- Alphagan (brimonidine): An alpha-agonist eye drop for lowering IOP in glaucoma patients.
