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Brinzolamide

Brinzolamide is a medication used to lower intraocular pressure (IOP) in individuals with open-angle glaucoma or ocular hypertension. By reducing IOP, Brinzolamide helps to prevent damage to the optic nerve, which can lead to vision loss or blindness if untreated. Brinzolamide is classified as a carbonic anhydrase inhibitor, which works by decreasing the production of aqueous humor, the fluid in the eye that contributes to IOP.

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Frequently Asked Questions

How long does it take for Brinzolamide to start working?
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Brinzolamide typically begins to lower intraocular pressure within a few hours of application, with the full effect seen within 2-4 hours.

Can I use Brinzolamide with contact lenses?
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Yes, but contact lenses should be removed before applying the ophthalmic suspension and can be reinserted 15 minutes after application. The suspension can be absorbed by soft lenses, so it is important to follow this guideline.

What should I do if I miss a dose of Brinzolamide?
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If you miss a dose, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time. Do not apply extra drops to make up for the missed dose.

Is Brinzolamide safe to use during pregnancy?
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The safety of Brinzolamide during pregnancy has not been fully established. Pregnant women or those planning to become pregnant should consult their healthcare provider to discuss the potential risks and benefits before using this medication.

Can Brinzolamide cause blurred vision?
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Yes, blurred vision is a common side effect of Brinzolamide, particularly immediately after application. This effect is usually temporary, but patients should avoid driving or operating heavy machinery until their vision clears.

Comprehensive Drug Guide

How Does Brinzolamide Work?

Brinzolamide works by inhibiting carbonic anhydrase, an enzyme found in the ciliary processes of the eye. By blocking this enzyme, Brinzolamide reduces the formation of bicarbonate ions, which are necessary for the production of aqueous humor. The decrease in aqueous humor production leads to a reduction in intraocular pressure, which is beneficial for patients with glaucoma or ocular hypertension.



What is Brinzolamide Used For?

Reduction of Elevated Intraocular Pressure (IOP): In patients with open-angle glaucoma or ocular hypertension. It is often used as monotherapy or as an adjunct to other IOP-lowering medications.

Common Dosages

Brinzolamide is available by prescription only and is not classified as a controlled substance. It is commonly available as an ophthalmic suspension (eye drops) with a concentration of 1%. The medication is often marketed under the brand name Azopt.

Administration: Apply one drop of Brinzolamide into the affected eye(s) two to three times daily. To avoid contamination, do not touch the dropper tip to any surface, including the eye. After applying the drops, close your eyes and press your finger gently against the inner corner of the eye (near the nose) for 1-2 minutes to prevent the medication from draining away.

Contact Lenses: Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them, as the suspension can be absorbed by soft lenses.

Typical Dosing

FDA Approved Indications

Ophthalmic Suspension: One drop in the affected eye(s) two to three times daily.


Who Shouldn't Take Brinzolamide?

Brinzolamide is contraindicated in patients with:

  • Known hypersensitivity to Brinzolamide, sulfonamides, or any component of the formulation.
  • Severe renal impairment due to the risk of systemic acidosis.

Advice From The Pharmacist

Patients using Brinzolamide should be advised to:

  • Use the medication exactly as prescribed and not exceed the recommended dosage.
  • Shake the bottle well before each use to ensure the suspension is properly mixed.
  • Wait at least 5-10 minutes before using any other eye drops to ensure proper absorption of each medication.
  • Inform their healthcare provider if they experience any severe side effects, such as persistent eye discomfort, vision changes, or signs of an allergic reaction.
  • If using contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them.


Side Effects of Brinzolamide

Common Side Effects

  • Blurred vision
  • Bitter or unusual taste in the mouth
  • Eye discomfort, dryness, or redness
  • Feeling of something in the eye
  • Headache

Uncommon/Severe Side Effects

  • Severe allergic reactions, such as rash, itching, swelling, or difficulty breathing
  • Persistent eye pain or vision changes
  • Signs of systemic acidosis, such as unusual tiredness, muscle pain, or rapid breathing (rare)

Patients should seek immediate medical attention if they experience severe or persistent side effects.

Risks and Warnings of Brinzolamide

Sulfonamide Allergy: Brinzolamide is a sulfonamide derivative, and although it is applied topically, it may still cause allergic reactions in patients who are sensitive to sulfonamides. Patients with a history of sulfonamide allergy should use Brinzolamide with caution.

Systemic Absorption: Although Brinzolamide is applied topically to the eye, some systemic absorption may occur. This can lead to side effects typically associated with systemic carbonic anhydrase inhibitors, such as metabolic acidosis, particularly in patients with renal impairment.

Caution in Renal Impairment: Brinzolamide should be used with caution in patients with renal impairment due to the risk of systemic acidosis.

Interactions with Brinzolamide

Common Drug Interactions

Brinzolamide may interact with other medications, including:

Oral Carbonic Anhydrase Inhibitors: Concurrent use with systemic carbonic anhydrase inhibitors (e.g., acetazolamide) is not recommended due to the increased risk of systemic side effects, such as acidosis.

High-dose Salicylates: Use with caution, as salicylates can increase the risk of systemic acidosis when used with carbonic anhydrase inhibitors.

Other Glaucoma Medications: Brinzolamide is often used in combination with other IOP-lowering medications, such as beta-blockers or prostaglandin analogs. Patients should inform their healthcare provider of all medications they are using to avoid potential interactions.

Alternatives to Brinzolamide

Alternative treatments for glaucoma or ocular hypertension include:

  • Prostaglandin Analogs: Such as latanoprost or travoprost, which increase the outflow of aqueous humor to lower IOP.
  • Beta-Blockers: Such as timolol, which decreases aqueous humor production.
  • Alpha-2 Adrenergic Agonists: Such as brimonidine, which reduces aqueous humor production and increases its outflow.
  • Combination Eye Drops: That include multiple active ingredients, such as Cosopt (dorzolamide/timolol) or Combigan (brimonidine/timolol).

The choice of treatment depends on the specific condition, the patient’s response to previous treatments, and any underlying medical conditions.