NiHowdy > Drug Classes > Sulfonylureas

Browse Medications by Drug Class: Sulfonylureas

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Sulfonylureas?

Sulfonylureas are a class of oral medications used to manage type 2 diabetes by increasing insulin production from the pancreas. They work by stimulating the pancreatic beta cells to release more insulin, thereby lowering blood sugar levels. Sulfonylureas are particularly effective in patients whose bodies can still produce some insulin but have difficulty regulating glucose levels. A unique characteristic of sulfonylureas is their ability to provide consistent glucose control, especially when combined with lifestyle modifications or other diabetes medications. NiHowdy ensures affordable access to these effective treatments, empowering patients to manage their diabetes effectively.

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List of drugs in Sulfonylureas

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Amaryl	Amaryl Information	Amaryl Pricing
Duetact	Duetact Information	Duetact Pricing
Glimepiride	Glimepiride Information	Glimepiride Pricing
glipiZIDE	glipiZIDE Information	glipiZIDE Pricing
glipiZIDE ER	glipiZIDE ER Information	glipiZIDE ER Pricing
glipiZIDE XL	glipiZIDE XL Information	glipiZIDE XL Pricing
glipiZIDE-metFORMIN HCl	glipiZIDE-metFORMIN HCl Information	glipiZIDE-metFORMIN HCl Pricing
Glucotrol XL	Glucotrol XL Information	Glucotrol XL Pricing
glyBURIDE	glyBURIDE Information	glyBURIDE Pricing
glyBURIDE Micronized	glyBURIDE Micronized Information	glyBURIDE Micronized Pricing
glyBURIDE-metFORMIN	glyBURIDE-metFORMIN Information	glyBURIDE-metFORMIN Pricing
Glynase	Glynase Information	Glynase Pricing
TOLBUTamide	TOLBUTamide Information	TOLBUTamide Pricing

Brief history about Sulfonylureas?

Sulfonylureas were first discovered in the 1940s during research into antibacterial compounds. Their glucose-lowering effects were later identified, leading to the development of tolbutamide, the first sulfonylurea approved for diabetes treatment in the 1950s. Over the years, second-generation sulfonylureas such as glipizide, glyburide, and glimepiride were introduced, offering enhanced potency and a more favorable safety profile. These medications remain a cornerstone in the management of type 2 diabetes, particularly in resource-limited settings. NiHowdy simplifies access to these cost-effective therapies, ensuring affordability for patients managing diabetes.

How do Sulfonylureas work?

Sulfonylureas work by binding to specific receptors (SUR1) on pancreatic beta cells, stimulating the release of insulin. This process is glucose-independent, meaning insulin is released even at low blood sugar levels. The increased insulin helps transport glucose into cells, reducing blood sugar levels. For example, glimepiride is known for its long-lasting effects, providing steady glucose control throughout the day. NiHowdy ensures patients can access these tried-and-true therapies affordably, supporting comprehensive diabetes management.

What are Sulfonylureas used to treat?

Type 2 Diabetes Mellitus

Sulfonylureas are primarily used to treat type 2 diabetes by improving insulin secretion and reducing blood sugar levels. They are particularly effective in patients with preserved pancreatic beta-cell function and are often combined with other antidiabetic agents to achieve optimal glycemic control.

Who should consider Sulfonylureas medications?

Adults

Adults with type 2 diabetes who have residual pancreatic beta-cell function and need improved glycemic control are ideal candidates for sulfonylureas. These medications are especially beneficial for patients who prefer oral therapies over injectable options. Healthcare providers carefully assess individual needs to optimize therapy.

Children

Sulfonylureas are rarely used in pediatric populations but may be considered in exceptional cases of type 2 diabetes or specific forms of genetic diabetes (e.g., maturity-onset diabetes of the young). Close monitoring and tailored dosing ensure safety and effectiveness in younger patients.

Seniors

Seniors with type 2 diabetes can benefit from sulfonylureas, but they require cautious use due to the increased risk of hypoglycemia and potential interactions with other medications. Regular monitoring and dose adjustments are essential to minimize risks while maintaining glucose control.

Are Sulfonylureas safe?

Sulfonylureas are generally safe and effective when used as prescribed. Common side effects include hypoglycemia (low blood sugar), weight gain, and mild gastrointestinal discomfort. Rare but serious risks include severe hypoglycemia, particularly in older adults or those with kidney impairment. Regular monitoring and adherence to prescribed regimens ensure the safe use of these medications.

Can I take Sulfonylureas during pregnancy?

The safety of sulfonylureas during pregnancy varies. While not typically first-line therapy, certain sulfonylureas may be used off-label in cases where insulin therapy is not feasible. Pregnant individuals should consult their healthcare provider to evaluate the risks and benefits of using these medications.

Are Sulfonylureas safe to take while lactating?

The safety of sulfonylureas during breastfeeding is not well-established, and their use is generally avoided due to potential transfer into breast milk. Lactating individuals should consult their healthcare provider for alternative treatment options.

Are Sulfonylureas controlled substances?

Sulfonylureas are not classified as controlled substances. They are available by prescription for managing type 2 diabetes. Regular follow-ups with healthcare providers ensure proper use and monitoring.

Side effects of Sulfonylureas?

Sulfonylureas are effective medications but may cause side effects. Common side effects include hypoglycemia, weight gain, and mild gastrointestinal symptoms like nausea or bloating. These effects are generally manageable with proper dosing and meal planning. Less common side effects include skin reactions, such as rash or sensitivity to sunlight, and mild liver enzyme elevations. These symptoms usually resolve with dose adjustments or discontinuation of the medication. Rare but serious side effects include severe hypoglycemia, particularly in patients with kidney or liver impairment, or those taking high doses. Patients should monitor for symptoms like sweating, shakiness, or confusion and seek immediate medical attention if they occur. Healthcare providers recommend regular blood sugar monitoring and adherence to prescribed regimens to minimize side effects. Open communication with healthcare providers ensures safe and effective use, optimizing outcomes for patients with type 2 diabetes.

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Cost considerations and insurance coverage for Sulfonylureas

Sulfonylureas are among the most affordable antidiabetic medications, with generic options like glipizide and glyburide widely available. Most insurance plans cover these drugs for type 2 diabetes treatment. NiHowdy offers discounts, rebates, and Bitcoin rewards to further reduce costs, making these therapies accessible to all patients.

How do I get rebates on Sulfonylureas?

NiHowdy's Bitcoin rebate program for sulfonylureas provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing diabetes both affordable and rewarding, ensuring access to effective treatments while building long-term value.

Therapeutic Classes linked to Sulfonylureas

Antidiabetics (Diabetes Management)

Everyday Health Concerns related to Sulfonylureas

Endocrine

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