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glyBURIDE-metFORMIN
Glyburide-Metformin is a combination oral medication used for the management of type 2 diabetes mellitus. It combines two antihyperglycemic agents: glyburide, a sulfonylurea that stimulates insulin release from the pancreas, and metformin hydrochloride, a biguanide that decreases hepatic glucose production and improves insulin sensitivity. This combination helps to control blood sugar levels effectively in individuals with type 2 diabetes.
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Frequently Asked Questions
How long does it take for Glyburide-Metformin to start working?
Patients may begin to notice improvements in their blood sugar levels within a few days, but optimal control may take weeks.
Can I take Glyburide-Metformin while breastfeeding?
Consult your healthcare provider for advice, as the safety of glyburide and metformin during breastfeeding should be evaluated.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Are there any specific dietary restrictions while taking Glyburide-Metformin?
Follow a diabetic diet as advised by your healthcare provider, focusing on balanced meals to help manage blood sugar levels.
What should I do if I experience severe side effects?
Contact your healthcare provider immediately if you experience severe side effects, such as signs of lactic acidosis or severe hypoglycemia.
Comprehensive Drug Guide
How Does glyBURIDE-metFORMIN Work?
Glyburide-Metformin works synergistically to lower blood glucose levels. Glyburide stimulates the pancreas to release more insulin in response to meals, while metformin reduces glucose production in the liver and enhances the uptake of glucose by peripheral tissues, thereby improving insulin sensitivity.
Common Dosages
Glyburide-Metformin is available in the following forms:
- Tablets: Common strengths include 1.5 mg/500 mg, 2.5 mg/500 mg, 5 mg/500 mg, and 5 mg/1000 mg (glyburide/metformin).
Typical Dosing
The typical dosing for Glyburide-Metformin is:
- For Type 2 Diabetes: The usual starting dose is one tablet taken orally with meals, typically 2-3 times daily. The dose may be adjusted based on blood glucose levels and tolerability.
Typical Dosing
FDA Approved Indications
- Management of type 2 diabetes mellitus as an adjunct to diet and exercise.
Who Shouldn't Take glyBURIDE-metFORMIN?
- Severe Renal Impairment: Not recommended for patients with significant renal dysfunction.
- Hypersensitivity: Known hypersensitivity to glyburide, metformin, or any components of the formulation.
- Diabetic Ketoacidosis: Should not be used in cases of diabetic ketoacidosis or coma.
Advice From The Pharmacist
- How to Take: Take Glyburide-Metformin with meals to reduce the risk of gastrointestinal side effects. Consistent timing with meals helps manage blood sugar levels effectively.
- Monitoring: Regular monitoring of blood glucose levels is essential. Periodic renal function tests are recommended while on metformin.
- Diet and Exercise: Emphasize the importance of adhering to a diabetic diet and regular exercise for optimal management of diabetes.
Side Effects of glyBURIDE-metFORMIN
Common Side Effects
- Nausea
- Diarrhea
- Abdominal discomfort
- Hypoglycemia (low blood sugar)
Uncommon/Severe Side Effects
- Lactic Acidosis: A rare but serious condition that can occur with metformin, characterized by muscle pain, difficulty breathing, and unusual fatigue.
- Severe Hypoglycemia: Particularly if meals are skipped or intake of carbohydrates is insufficient.
Risks and Warnings of glyBURIDE-metFORMIN
- Lactic Acidosis: Monitor for symptoms, especially in patients with renal impairment or other risk factors.
- Hypoglycemia Risk: Educate patients on the signs and symptoms of low blood sugar and how to manage it.
- Regular Check-Ups: Regular follow-ups with healthcare providers are necessary to assess the effectiveness and safety of the treatment.
Interactions with glyBURIDE-metFORMIN
Common Drug Interactions
- Drug Interactions: Glyburide-Metformin may interact with other medications that can affect blood sugar levels, including other antidiabetic agents, corticosteroids, and certain antibiotics. Always inform your healthcare provider about all medications you are taking.
- Food Interactions: Take with food to reduce the risk of gastrointestinal side effects.
Alternatives to glyBURIDE-metFORMIN
Other Oral Antidiabetic Agents: Such as metformin alone, or other combinations like metformin with other sulfonylureas.
