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Glimepiride
Glimepiride is a medication used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It works by causing the release of your body's natural insulin. Controlling high blood sugar helps prevent kidney damage, nerve issues, loss of limbs, and sexual function problems. Common side effects include nausea, stomach upset, or diarrhea may occur initially but will diminish with continuous usage.
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Frequently Asked Questions
Can glimepiride make me feel dizzy or drowsy?
Yes, taking glimepiride can lower your blood sugar levels, leading to symptoms like dizziness, shakiness, and sweating. It's crucial to always have a sugar source on hand to quickly raise your blood sugar levels.
Can I consume alcohol while taking glimepiride?
No, consuming alcohol could increase the risk of experiencing hypoglycemia, or it may interfere with the effect of Glimepiride. It's best to limit alcohol while under this medication.
Can I take glimepiride if I have kidney disease?
It's generally advised to avoid glimepiride if you have severe kidney disease or dialysis. Consult your doctor to discuss alternative medications.
Does glimepiride cause weight gain?
Yes, weight gain is a potential side effect of glimepiride due to the improvement in the regulation of your body's sugar levels.
I missed a dose of glimepiride, what should I do?
Take it as soon as you remember. If it's almost time for your next dose, skip the missed one. Do not double up on doses to make up for the missed one.
Is it safe to take glimepiride during pregnancy or while breastfeeding?
Glimepiride is rated as category C in pregnancy. This means that risks cannot be ruled out. A safer alternative could be insulin therapy during pregnancy and breastfeeding.
Comprehensive Drug Guide
How Does Glimepiride Work?
Glimepiride is an oral bloodglucoselowering drug of the sulfonylurea class, stimulating insulin release from functioning pancreatic ?cells and increasing insulin sensitivity at peripheral targets.
What is Glimepiride Used For?
FDA indications: Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes.
Offlabel uses: It's also used in polycystic ovary syndrome (PCOS) as it reduces insulin resistance thus reducing the signs and symptoms of PCOS.
Common Dosages
Tablets: 1mg, 2mg, 3mg, 4mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications: The usual maintenance dose is 1 to 4mg once daily, administered with breakfast or first main meal. The maximum recommended dose is 8mg taken once daily.
Off-Label Uses
- For offlabel uses: The dosage of Glimepiride must be individualized based on both effectiveness and tolerance while not exceeding the maximum recommended dose of 8mg.
Who Shouldn't Take Glimepiride?
- Allergic to glimepiride or any ingredients of the medication.
- Have a history of diabetic ketoacidosis or type 1 diabetes.
- Are pregnant or trying to become pregnant.
- Have liver disease.
- Have acute insulin toxicity (insulin shock).
- Are in a state of diabetic precoma or coma.
- Experience severe impairment of kidney function.
Advice From The Pharmacist
- Follow a regular meal schedule. Do not skip meals.
- Maintain regular exercise. This is especially critical to diabetes management.
- This medication should be taken with food to avoid an upset stomach.
- Always remain hydrated and limit drinking alcohol.
- Glimepiride can cause hypoglycemia, which could lead to seizures or loss of consciousness. Always keep a sugar source handy.
- Do not stop taking Glimepiride without consulting with your healthcare provider
Side Effects of Glimepiride
Common Side Effects
- You may feel lightheaded, sweaty, faint, or shaky. Watch for signs of low blood sugar like hunger, nervousness, and mood changes.
- Nausea, stomach pain, injuries, and body aches can occur.
Uncommon/Severe Side Effects
- Rare side effects:
- Seek immediate medical help if symptoms of allergic reactions happen; such as dizziness, breathing problems, or swelling of face, lips, tongue, or throat.
Risks and Warnings of Glimepiride
- Overdose can lead to severe hypoglycemia. Keep sugar sources on hand.
- Avoid excessive intake of alcohol. It can either potentiate or weaken the glucoselowering effect of glimepiride in an unpredictable fashion.
Interactions with Glimepiride
Common Drug Interactions
- BetaBlockers, NSAIDs, Sulfa Drugs, MAO Inhibitors, and Salicylates
- Aspirin, azole antifungals, and Disopyramide
- Fluconazole, Miconazole, and Voriconazole
Alternatives to Glimepiride
- Metformin
- Pioglitazone
- Rosiglitazone
- Repaglinide
- Nateglinide
