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Fluconazole
Fluconazole is an antifungal medication used to treat and prevent a variety of fungal and yeast infections. It works by stopping the growth of certain types of fungus.
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Comprehensive Drug Guide
How Does Fluconazole Work?
Fluconazole works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. In doing so, it disrupts the functioning of the cell membrane and inhibits fungal growth.
What is Fluconazole Used For?
Fluconazole is mainly used for treating several types of fungal and yeast infections, such as thrush, cryptococcal meningitis, and vaginal yeast infections
Common Dosages
- Tablets: 50mg, 100mg, 150mg, 200mg
- Oral Suspension: 10mg/mL, 40mg/mL, 50mg/5mL, 200mg/5mL
Typical Dosing
FDA Approved Indications
- Vaginal candidiasis: A single oral dose of 150mg for uncomplicated cases.
- Thrush: 200mg as the first dose, followed by 100mg once daily for at least 3 weeks. Continue treatment for at least 2 weeks following resolution of symptoms.
- For off-label uses:
Off-Label Uses
It's also used off-label for ringworm, blastomycosis, coccidiomycosis, and cutaneous leishmaniasis
- Ringworm: 150mg once weekly for 4 to 5 weeks.
- Blastomycosis: 400 to 800mg once daily for 6 to 12 months
- Cutaneous leishmaniasis: 200mg orally daily for 6 weeks
Pediatric Dosing
- Pediatric dosing of fluconazole depends on the type of infection it's used to treat and the child's weight. Always follow the doctor's instructions.
- Longer courses of treatment may be necessary for some types of infection.
- Monitor children for possible side effects, such as stomach upset or rash.
Who Shouldn't Take Fluconazole?
- Have allergic reactions to fluconazole or other antifungal medicines
- Suffer from liver disease or heart disease.
- Are pregnant, or planning to become pregnant.
- Take certain medications, such as cisapride and pimozide, because of the risk of serious cardiac events.
Advice From The Pharmacist
- Drink plenty of water while you are taking fluconazole.
- Take fluconazole at the same time each day to ensure consistent levels of medicine in your body.
- Continue to take this medicine as directed by your doctor, even after symptoms disappear.
- Avoid consuming alcohol while taking fluconazole as it may increase liver damage risk.
- Do not skip doses or stop taking fluconazole without your doctor's approval.
Side Effects of Fluconazole
Common Side Effects
- You might feel an upset stomach, diarrhea, nausea, vomiting, headache, or skin rash.
Uncommon/Severe Side Effects
- You might experience dizziness, chest palpitations, shortness of breath, or severe skin reactions.
- Toxic epidermal necrolysis
- Seizures
Interactions with Fluconazole
Common Drug Interactions
- Warfarin
- Phenytoin
- Cyclosporine
- Rifampin
- Theophylline
- Antipsychotic drugs (like clozapine)
Alternatives to Fluconazole
- Ketoconazole
- Itraconazole
- Voriconazole
- Amphotericin B
- Nystatin
