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Zylet
Zylet is a combination eye drop that contains loteprednol etabonate, a corticosteroid, and tobramycin, an aminoglycoside antibiotic. It is used to treat inflammatory eye conditions that have or are at risk of developing bacterial infections. The corticosteroid helps reduce swelling, redness, and itching, while the antibiotic prevents bacterial growth in the affected eye.
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Frequently Asked Questions
How long does it take for Zylet to start working?
Most patients experience relief from inflammation and infection within the first 1-2 days of using Zylet. However, full symptom relief may take a few more days depending on the severity of the condition.
Can I use Zylet if I wear contact lenses?
You should not wear contact lenses while using Zylet, especially if you have an active eye infection. Wait at least 15 minutes after using the drops before reinserting your lenses.
How long can I use Zylet?
Zylet should only be used for as long as your healthcare provider recommends. Prolonged use can increase the risk of developing side effects such as increased eye pressure or cataracts.
What should I do if I miss a dose of Zylet?
If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular schedule. Do not use double doses.
Can Zylet be used for viral eye infections?
No, Zylet is not effective against viral infections and should not be used if you have a known viral infection, such as herpes simplex keratitis.
Comprehensive Drug Guide
How Does Zylet Work?
- Loteprednol etabonate reduces inflammation by suppressing the immune response in the eye, helping to alleviate redness, swelling, and discomfort.
- Tobramycin disrupts the bacterial cell wall, preventing the bacteria from multiplying and eliminating existing bacterial infections in the eye.
Common Dosages
- Loteprednol etabonate: 0.5%
- Tobramycin: 0.3%
Typical Dosing
The typical dosing for Zylet is:
- 1-2 drops instilled into the affected eye(s) every 4-6 hours. In some cases, the dose may be increased to every 2 hours during the initial 24-48 hours of treatment, followed by a gradual reduction based on symptom improvement.
Typical Dosing
FDA Approved Indications
- Inflammatory ocular conditions where there is a risk of bacterial infection
- Post-surgical inflammation that has a risk of developing a bacterial infection
Who Shouldn't Take Zylet?
- Viral eye infections such as herpes simplex, vaccinia, or varicella
- Fungal infections of the eye
- Hypersensitivity to any components of the medication (loteprednol or tobramycin)
Advice From The Pharmacist
- Shake the bottle well before each use to ensure the suspension is evenly mixed.
- Avoid touching the tip of the bottle to any surface, including your eye, to prevent contamination.
- If you wear contact lenses, remove them before using Zylet and wait at least 15 minutes before reinserting them.
- If you are prescribed more than one type of eye drop, wait at least 5 minutes between using different medications.
Side Effects of Zylet
Common Side Effects
- Temporary blurred vision
- Eye redness or discomfort
- Sensitivity to light
Uncommon/Severe Side Effects
- Increased intraocular pressure (leading to glaucoma)
- Worsening of existing viral or fungal eye infections
- Cataract formation with long-term use
Risks and Warnings of Zylet
- Increased Intraocular Pressure: Prolonged use of corticosteroids like loteprednol can lead to increased eye pressure, which can cause glaucoma. Regular monitoring of eye pressure may be necessary if Zylet is used for an extended period.
- Infection Risk: Long-term use of steroids can increase the risk of developing or worsening bacterial, viral, or fungal eye infections.
- Cataracts: Extended use of steroid-containing eye drops may lead to the development of cataracts.
Interactions with Zylet
Common Drug Interactions
- Other eye medications: If using multiple eye drops, wait at least 5 minutes between different medications to ensure proper absorption.
- Systemic steroids: Combining systemic corticosteroids with Zylet may increase the risk of steroid-related side effects such as immune suppression.
Alternatives to Zylet
- Maxitrol (dexamethasone/neomycin/polymyxin B): Another combination of a corticosteroid and antibiotics for treating inflammatory eye conditions with a risk of infection.
- Tobradex (dexamethasone/tobramycin): A similar combination of tobramycin and dexamethasone for eye inflammation and infection risk.
- Prednisolone acetate: A corticosteroid for inflammation, often used alone when bacterial infection risk is not present.
