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prednisoLONE
Prednisolone is a corticosteroid used to reduce inflammation in a variety of conditions, including asthma, allergic reactions, autoimmune diseases, and certain eye conditions. It works by suppressing the immune response and reducing inflammation, helping to alleviate symptoms like swelling, redness, and pain. Prednisolone is commonly prescribed for both short-term relief of acute symptoms and long-term management of chronic conditions.
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Frequently Asked Questions
How long does it take for Prednisolone to work?
Prednisolone begins to reduce inflammation and symptoms within a few hours of the first dose, but the full effects may take a few days depending on the condition being treated.
Can Prednisolone cause weight gain?
Yes, weight gain is a common side effect of prednisolone, especially with long-term use, due to increased appetite and fluid retention.
What should I do if I miss a dose of Prednisolone?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Can I take Prednisolone long-term?
Prednisolone can be taken long-term for certain chronic conditions, but it requires close monitoring by your healthcare provider to manage side effects like bone loss and adrenal suppression.
Can Prednisolone be used in children?
Yes, prednisolone is often used in children to treat asthma, allergies, and other conditions. However, long-term use in children requires careful monitoring to avoid potential side effects, such as growth suppression.
Comprehensive Drug Guide
How Does prednisoLONE Work?
Prednisolone works by mimicking the action of cortisol, a natural hormone produced by the adrenal glands. It suppresses the activity of the immune system by reducing the production of inflammatory chemicals and decreasing the activity of white blood cells, which helps to reduce inflammation and the immune response in affected tissues.
Common Dosages
- Oral tablets: 5 mg, 10 mg, 20 mg, 40 mg
- Oral suspension: 15 mg/5 mL
- Eye drops: 1% solution
Typical Dosing
- For inflammatory or allergic conditions, the dose varies depending on the severity of the condition and the patient’s response. The typical dose for adults is 5 mg to 60 mg daily, with adjustments made based on the condition being treated.
- For eye inflammation, the typical dose is 1 to 2 drops of the 1% solution in the affected eye(s) 2 to 4 times daily.
Typical Dosing
FDA Approved Indications
- Asthma
- Allergic conditions (e.g., allergic rhinitis, contact dermatitis)
- Autoimmune diseases (e.g., rheumatoid arthritis, lupus)
- Inflammatory eye conditions (e.g., uveitis)
- Adrenal insufficiency
It is also used off-label for conditions like multiple sclerosis and Crohn's disease.
Who Shouldn't Take prednisoLONE?
- Untreated systemic fungal infections
- Known hypersensitivity to prednisolone or any of its components
- Live virus vaccines in individuals receiving immunosuppressive doses of corticosteroids
Advice From The Pharmacist
- Take prednisolone with food to prevent stomach irritation.
- For patients using eye drops, avoid touching the dropper to your eye or any surface to prevent contamination.
- Do not stop prednisolone suddenly, especially if you have been on it for a long time. Tapering is necessary to prevent withdrawal symptoms or adrenal insufficiency.
- Monitor for infections, as prednisolone can suppress the immune system and increase the risk of infections.
Side Effects of prednisoLONE
Common Side Effects
- Increased appetite
- Weight gain
- Insomnia
- Mood changes
- Upset stomach
Uncommon/Severe Side Effects
- Osteoporosis (with long-term use)
- Adrenal suppression
- Increased risk of infections
- Cataracts or glaucoma (with long-term use of eye drops)
Risks and Warnings of prednisoLONE
- Adrenal Suppression: Long-term use of prednisolone can cause the adrenal glands to stop producing cortisol, leading to adrenal insufficiency. Tapering the dose gradually is essential when stopping long-term use.
- Increased Risk of Infections: Prednisolone suppresses the immune system, which can make it harder for your body to fight infections.
- Bone Health: Long-term use of prednisolone can lead to osteoporosis and bone fractures, especially in older adults.
Interactions with prednisoLONE
Common Drug Interactions
- NSAIDs (e.g., ibuprofen): Can increase the risk of gastrointestinal bleeding.
- Live vaccines: Should be avoided, as prednisolone can reduce the immune response.
- Diabetes medications: Prednisolone can increase blood sugar levels, making it harder to control diabetes.
Alternatives to prednisoLONE
- Methylprednisolone (Medrol®): Another corticosteroid used for inflammatory and allergic conditions.
- Hydrocortisone: A milder corticosteroid for less severe inflammatory conditions.
- Dexamethasone: A more potent corticosteroid used for severe inflammation and certain cancers.
