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TobraDex
TobraDex is a combination medication containing tobramycin, an aminoglycoside antibiotic, and dexamethasone, a corticosteroid. It is used to treat bacterial eye infections and reduce inflammation. Tobramycin works by killing bacteria that cause the infection, while dexamethasone reduces swelling, redness, and irritation associated with the infection or surgery.
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Frequently Asked Questions
How long does it take for TobraDex to work?
You may notice improvement in your symptoms within 1 to 2 days of starting TobraDex, but it’s important to complete the full course of treatment as prescribed.
Can I use TobraDex for viral or fungal eye infections?
No, TobraDex is not effective against viral or fungal eye infections. It should only be used for bacterial infections and inflammation related to bacterial infections or surgery.
What should I do if I miss a dose of TobraDex?
If you miss a dose, apply it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Can TobraDex cause blurry vision?
Yes, temporary blurry vision is a common side effect after applying the eye drops or ointment. This should resolve within a few minutes after application.
How long can I use TobraDex?
TobraDex should generally not be used for longer than 2 weeks, unless directed by your doctor. Prolonged use can increase the risk of side effects like glaucoma or cataracts.
Comprehensive Drug Guide
How Does TobraDex Work?
Tobramycin works by inhibiting bacterial protein synthesis, effectively killing bacteria and treating the infection. Dexamethasone reduces inflammation by suppressing the body’s immune response, alleviating redness, swelling, and pain.
Common Dosages
- Ophthalmic suspension (eye drops): 0.3% tobramycin and 0.1% dexamethasone
- Ophthalmic ointment: 0.3% tobramycin and 0.1% dexamethasone
Typical Dosing
- For bacterial infections and inflammation: Apply one or two drops of TobraDex ophthalmic suspension in the affected eye(s) every 4 to 6 hours. For severe infections, your doctor may recommend increasing the frequency to every 2 hours initially. The ointment is typically applied 2 to 3 times a day or as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Bacterial infections of the eye
- Post-surgical inflammation following eye surgery
- Inflammation associated with bacterial infections
Who Shouldn't Take TobraDex?
- Viral, fungal, or mycobacterial eye infections (e.g., herpes simplex, tuberculosis)
- Known hypersensitivity to tobramycin, dexamethasone, or any components of the formulation
Advice From The Pharmacist
- Shake the eye drops well before each use to ensure proper suspension.
- Do not wear contact lenses during treatment, as this can worsen the infection or cause irritation.
- Do not touch the dropper tip or tube opening to any surface, including your eye, to avoid contamination.
- Complete the full course of treatment, even if symptoms improve, to prevent the infection from returning.
Side Effects of TobraDex
Common Side Effects
- Temporary blurred vision
- Eye redness or irritation
- Eye discomfort or itching
- Tearing or watery eyes
Uncommon/Severe Side Effects
- Increased intraocular pressure (IOP)
- Glaucoma (with long-term use)
- Cataract formation
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of TobraDex
- Increased Intraocular Pressure: Prolonged use of corticosteroids like dexamethasone can increase IOP, which may lead to glaucoma. Regular monitoring is recommended for patients using TobraDex long-term.
- Masking of Infections: The steroid component can mask or worsen existing viral or fungal infections. If symptoms worsen, discontinue use and consult your doctor.
- Cataracts: Long-term use of corticosteroids may increase the risk of developing cataracts. Regular eye exams are recommended for those using TobraDex for extended periods.
Interactions with TobraDex
Common Drug Interactions
- Other corticosteroids: Combining TobraDex with other corticosteroid-containing products may increase the risk of side effects like increased IOP or cataracts.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Using TobraDex with NSAIDs may increase the risk of corneal complications, such as ulcers.
Alternatives to TobraDex
- Maxitrol (neomycin, polymyxin B, dexamethasone): A combination antibiotic and steroid used for bacterial eye infections and inflammation.
- Vigamox (moxifloxacin): A fluoroquinolone antibiotic used for bacterial infections of the eye without a steroid component.
- Prednisolone acetate: A corticosteroid eye drop used for inflammation, without an antibiotic.
