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Tobramycin

Tobramycin is an antibiotic that's part of a group of medications known as aminoglycosides. It's super useful in treating different types of bacterial infections, particularly those caused by Gramnegative bacteria. Usual side effects can entail kidney problems and hearing damage, but your doctor will always weigh the risks versus the benefits.

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Frequently Asked Questions

Can I consume alcohol while using Tobramycin?
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There's no specific warning about drinking alcohol while using tobramycin. However, for your overall health, it's a good idea to limit alcohol intake when you're treating an infection.

Can I just stop taking Tobramycin once my symptoms are gone?
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No. To make sure that all the bacteria causing your infection are killed, it's essential to complete the entire prescribed course, even if you feel better before that.

Does Tobramycin cause any allergic reaction?
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Yes, an allergic reaction to tobramycin is possible, though it's not very common. If you experience any rash, itching, severe dizziness, or trouble breathing after using it, seek medical help immediately.

I missed a dose of Tobramycin, what should I do?
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If it's almost time for your next dose, skip the missed one. Otherwise, take the missed dose as soon as you remember. Don't take double doses though!

Comprehensive Drug Guide

How Does Tobramycin Work?

Tobramycin works by inhibiting synthesis in bacterial cells, causing them to misread coded genetic material, which effectively hampers their reproduction and growth.

What is Tobramycin Used For?

FDA indications: Tobramycin is used to treat a range of bacterial infections, including bacterial eye infections, and respiratory infections in patients with cystic fibrosis.

Offlabel uses: It might be employed for treating bacterial meningitis, septicemia, and urinary tract infections.

Common Dosages

Eye drops: 0.3%

Ophthalmic ointment: 0.3%

Inhalation use (nebulizer): 300mg/5mL

Intravenous or intramuscular use: 1.2 g/mL, 40mg/mL

Typical Dosing

FDA Approved Indications

  • Eye infections: 12 eye drop(s) every 4 hours for 7 to 10 days.
  • Respiratory infections in cystic fibrosis: Inhalation of 300 mg twice daily, 28 days on, 28 days off.

Off-Label Uses

  • Urinary tract Infections: Depends upon the severity and the individual's renal function. Usually 3 to 5 mg per kilogram of body weight, every 8 hours.

Who Shouldn't Take Tobramycin?

  • Have known hypersensitivity to tobramycin.
  • Are pregnant or breastfeeding, unless the benefit to the mother outweighs the risk to the fetus.
  • Have neuromuscular disorders like myasthenia gravis or Parkinson's disease.
  • Got kidney problems or have a history of renal impairment.
  • Have hearing problems or have a history of auditory impairment

Advice From The Pharmacist

  • Always complete the full amount of tobramycin prescribed by your doctor, even if you feel better before completion!
  • Avoid direct sunlight or bright light during and for several days after treatment.
  • Record all the side effects and share them with your doctor.
  • Follow the instructions on how to store tobramycin correctly.
  • Don't wear contact lenses while you're using tobramycin eye drops unless your doctor recommends the same.

Side Effects of Tobramycin

Common Side Effects

  • You may experience burning or stinging in the eyes.
  • Your eyes might become itchy or red.

Uncommon/Severe Side Effects

  • Uncommon side effects:
  • You might feel that something is in your eye.
  • Eyelid swelling and itching might occur.
  • Rare side effects:
  • You might have an allergic reaction.
  • Severe side effects:
  • Hearing changes like ringing in the ears.
  • Muscle weakness or numbness.

Risks and Warnings of Tobramycin

  • Tobramycin might cause fetal harm during pregnancy. So, if you are pregnant or planning to, consult with your doctor first.
  • Be cautious in case of myasthenia gravis, parkinsonism, or other neuromuscular issues.
  • If you have a history of kidney problems, tobramycin might exacerbate the condition.
  • In case you have problems with hearing or a family history, seek your doctor's advice before using this medication.

Interactions with Tobramycin

Common Drug Interactions

  • Diuretics like furosemide
  • Neuromuscular blockers like rocuronium
  • Cisplatin
  • Other aminoglycosides (gentamicin, amikacin)

Alternatives to Tobramycin

  • Gentamicin
  • Amikacin
  • Kanamycin
  • Neomycin
  • Streptomycin